Traditionally, alcohol has been recommended to nursing mothers as an aid to lactation.¹ Folklore relates that drinking small quantities of alcohol shortly before nursing increases milk yield, facilitates milk let-down, and relaxes both mother and infant.² ...

THE presence of a circadian pattern in the occurrence of several unfavorable and usually unpredictable cardiovascular events has been demonstrated in previous studies. There is higher systemic blood pressure^{1 , 2} and an increased frequency of episodes of ...

PAROXYSMAL nocturnal hemoglobinuria (PNH) is an acquired clonal stem-cell disorder^{1 , 2} with resultant defective and deficient hematopoiesis.^{3 , 4} It is characterized by an increased sensitivity of erythrocytes to the hemolytic action of complement.⁵ This ...

ATHEROSCLEROSIS may be initiated by endothelial injury, which then leads to the proliferation of intimal smooth-muscle cells.¹ The atherogenic smooth-muscle proliferation could be the result of the release of growth factors from platelets, leukocytes, or ...

THE effect of chronic low back pain on our society is enormous, in terms of both human suffering and cost.¹ Many treatments have been advocated, but few have been rigorously tested in controlled trials.

The facet joints of the vertebrae have been ...

Complications

Both ulcerative colitis and Crohn's disease are associated with a wide variety of complications, encompassing secondary effects of the inflammatory process in the gastrointestinal tract and associated extraintestinal manifestations.^{113 114 ...}

John A. Oates, M.D., Editor Alastair JJ. Wood, M.D., Associate Editor j

THE past 10 years have witnessed major changes in our understanding of the pathogenesis and treatment of what are commonly called the acid-peptic diseases. Schwarz's dictum — "without ...

Presentation of Case

A 48-year-old woman entered the hospital because of increasing weakness of the extremities and flexor muscles of the neck.

The patient was well until three years earlier, when a hysterectomy was performed because of profuse vaginal ...

The national and international medical community strongly advocates breast-feeding for the first three to six months of an infant's life.^{1 , 2} In less developed countries, the greatest virtues of breast milk are that it is economical, highly nutritious, ...

A morning increase in the risk of acute cardiovascular disorders — transient myocardial ischemia, myocardial infarction, sudden cardiac death, and stroke —is now well documented and widely accepted by both the medical profession and the public. Over the ...

The history of medical care for low back pain —one of the most common causes of morbidity and absenteeism in the United States — involves serial fashions in diagnosis and therapy. Earlier in this century, sacroiliac joint disease was thought to account ...

To the Editor: Halpern and Coren have reported a striking reduction in life expectancy associated with left-handedness (April 4 issue).* They state that their results implicate covert neuropathologic features as the cause of increased deaths, rather than ...

To the Editor: We are concerned that the study by Levran et al. (Oct. 25, 1990, issue)¹ suggests an inappropriately negative view of the value of embryo cryopreservation associated with in vitro fertilization. The reported results could have been ...

To the Editor: The use of intoxicants during pregnancy is recognized as being harmful to both the mother and the fetus.¹–⁴ Detecting such use in order to intervene should be part of routine prenatal care. In the study by Chasnoff et al. in the April 26, ...

To the Editor: The Canadian Hydroxychloroquine Study Group deserves credit for its attempt to test the effectiveness of hydroxychloroquine in systemic lupus erythematosus (Jan. 17 issue).¹ Unfortunately, there are two important aspects that need to be ...

To the Editor: In the recent report of the lack of effect of a calcium-entry blocker (lidoflazine) in comatose survivors of cardiac arrest (May 2 issue),¹ the discussion focuses on the drug's effect in blocking calcium entry. In fact, lidoflazine is very ...

To the Editor: I enjoyed reading the Weekly Clinicopathological Exercise in the May 2 issue,¹ but was astonished that no comment was made about the reported serum IgM level of 11,450 mg per 100 ml (114.5 g per liter) in a man of 67 years who survived a ...

To the Editor: Streptococcus pneumoniae has generally been sensitive to penicillin, but strains with intermediate resistance have been reported since 1967 and continue to appear sporadically, accounting for as much as 15 percent of S. pneumoniae isolates...

To the Editor: It has come to my attention that in some parts of the country children are allowed to observe their mother's delivery. In the hospitals where this has occurred, it has been on the basis of requests from parents to obstetricians, who have ...

The interplay between the normal physiologic changes of pregnancy and pathologic disease processes presents a challenge to physicians caring for pregnant patients with medical disorders. All too frequently, care is fragmented. The internist, understanding ...

This is the second edition of Clinical Physiology in Obstetrics, with five new authors. Born in 1964 as Physiology of Human Pregnancy (Hytten and Leitch), the book reached puberty in a second edition in 1971, today a classic. It was then replaced with ...

Infection in the neonate continues to be a major problem, especially in the "micropreemie," the newborn with a birth weight below 800 g. These infants are immunocompromised, with antibody deficiency, decreased neutrophil function, and altered production, ...

Despite a rapid increase in the number of cardiac arrhythmias encountered in pediatric cardiology, few textbooks are devoted to the topic. This is the editors' second book on the topic, and it is an expansion of their former effort (Pediatric Cardiac ...

A brief, concise, well-illustrated book on the essentials of pediatric dermatology is an excellent idea, since few of the many introductory dermatology textbooks focus on diseases of childhood. Thus, this attractively bound 221-page work appears to fill a ...

The title of this book is appropriate, because it is indeed a practical guide to the care of the adolescent. Whether by design or coincidence the attractive red cover with its geometric figure stands out as a symbol of the complexity of adolescence and ...

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INTERNATIONAL REGISTRY OF MUTANT p53 CARRIER STATE

In order to collect data on ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...