Septicemia is a leading cause of morbidity and mortality among hospitalized patients. There are approximately 400,000 cases each year in the United States, and the incidence continues to increase.¹ Gram-negative bacteremia occurs in about 30 percent of ...

SOFT-TISSUE tumors often present diagnostic challenges to the clinician and pathologist. In particular, despite the use of contemporary histologic, immunohistochemical, and electron-microscopical techniques, it can be difficult to determine the ...

NEONATAL herpes simplex virus (HSV) infection is associated with substantial morbidity and mortality, and its incidence is increasing in the United States.^{1 2 3} Since 1973, the National Institute of Allergy and Infectious Diseases Collaborative Antiviral ...

NEONATAL herpes simplex virus (HSV) infection is one of the most life-threatening of all infections in newborns, affecting approximately 1500 to 2200 babies per year in the United States.^{1 2 3 4} Although several clinical trials have documented the ...

IN this paper, we describe 10 patients seen over a six-year period with acute and chronic hepatitis in whom liver-biopsy specimens were characterized by the presence of giant multinucleated syncytial hepatocytes. Giant cells are a common pathological ...

HYPERKALEMIA is a common electrolyte disorder. Among its common causes are renal insufficiency; adrenal insufficiency; hyporeninemic hypoaldosteronism, usually associated with diabetes mellitus, mild renal insufficiency, tubulointerstitial nephritis, or a ...

CHILDHOOD cancer is rare in the United States, but it is the leading cause of death from disease in children 1 to 15 years old.¹ The majority of cancers in children are malignant solid tumors, and about 4000 new cases are diagnosed each year.¹ Enormous ...

Presentation of Case

A 21-year-old woman was admitted to the hospital because of a persistent rash on her elbow.

The patient was well until five weeks earlier, shortly before the end of a six-month stay in Costa Rica, when she became aware of a skin ...

It has been 40 years since the first description of bacteremia due to gram-negative rods appeared.¹ It has always been assumed that the endotoxins (lipopolysaccharides) of gram-negative bacteria were responsible for the clinical manifestations of ...

IN 1957 Hudson et al.¹ described a patient with isolated hypoaldosteronism who had hyperkalemia with low urinary aldosterone excretion, normal glucocorticoid secretion, and relatively normal renal function. We have since recognized a variety of disorders ...

Angley —John Cole Angley, M.D., of Bryantville, died on December 21 at the age of 84.

Dr. Angley graduated from Harvard Medical School in 1932. He was a member of the American Medical Association and a 50-year member of the Massachusetts Medical Society.

To the Editor: Dr. Salzman, in his Sounding Board article (Sept. 20 issue),¹ has identified key aspects of what he generously characterizes as an "unusual" marketing strategy employed by Sandoz in tying the availability of the new antipsychotic agent ...

To the Editor: Pedersen et al. (June 21 issue)¹ suggest that inosine pranobex delays the progression to the acquired immunodeficiency syndrome (AIDS) in patients with human immunodeficiency virus (HIV) infection. Their analysis controlled for several ...

To the Editor: We believe that Koralnik et al. have overemphasized the usefulness of electrophysiologic tests in their report (Sept. 27 issue)¹ on asymptomatic men seropositive for the human immunodeficiency virus (HIV). Their conclusion — that "in ...

To the Editor: Perrillo et al. (Aug. 2 issue)* reported the results of a randomized, controlled trial of interferon alfa-2b alone in high and low doses and after prednisone withdrawal for the treatment of chronic hepatitis B. The patients randomly ...

To the Editor: During the past five years, two established molecular virologists, each of whom had performed many experiments with SV40 virus and SV40-transformed cells, died of cancer. One had a malignant lymphoma of the nodular, poorly differentiated ...

To the Editor: The article by Dr. Rifkin et al. (Sept. 6 issue)¹ on the evaluation of the role of magnetic resonance imaging (MRI) and transrectal sonography in staging localized carcinoma of the prostate reports poor results that are consistent with our ...

To the Editor: Atrial fibrillation is uncommon in young patients without evidence of cardiac disease. We report on three patients in whom atrial fibrillation occurred in the setting of neurally mediated syncope. In all three patients, syncope was ...

To the Editor: Dr. Anderson's discussion of temporal arteritis in a recent case presentation (June 7 issue)¹ was thoughtful and thorough. However, as a rheumatologist with a particular interest in this disease, I must take exception to the statement of ...

To the Editor: The Sounding Board article by Schorr (Aug. 23 issue)* points out that the currently uninsured population cannot be covered effectively by employer-based health insurance. I agree with his assessment, because I believe there are substantial ...

To the Editor: When referring to the hand, the names digitus pollicis, indicis, medius, annularis, and minimus specify the five fingers. In situations of clinical relevance the use of such names can preclude anatomical ambiguity. These time-tested terms ...

Two national advisory groups have great influence with regard to the safe conduct of the population through an environment contaminated with ionizing radiation. These are the National Council on Radiation Protection and Measurements and the National ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Addresses of most overseas publishers are ...

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AMERICAN SOCIETY FOR CLINICAL PHARMACOLOGY AND THERAPEUTICS

The 92nd annual ...

With every important advance in medical care, the challenge of providing a country's population with comprehensive health services has become more formidable, because increases in the cost of such services continue to outstrip the rate of economic growth ...