The effectiveness of cyclosporine in the treatment of psoriasis was a serendipitous finding by Mueller and Herrmann,¹ who included four patients with psoriatic arthritis and psoriasis in a study of therapy for rheumatoid arthritis. We confirmed this ...

A LARGE number of previous studies, many epidemiologic in nature,^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20} have investigated the growing problem of death from asthma. Although these studies have identified such deaths as a major health policy ...

INFECTION with the human immunodeficiency virus (HIV) increases the risk of tuberculosis and is thought to decrease the effectiveness of antituberculosis treatment.¹ For this reason, the American Thoracic Society and the Centers for Disease Control (CDC) ...

LONG-TERM athletic training produces the increases in the diastolic dimension of the left ventricular cavity, in the thickness of the left ventricular wall, and in the calculated left ventricular mass that make up what is commonly known as the "athlete's ...

GYNECOMASTIA in prepubertal children usually results from an increase in endogenous estrogen production. Estrogen biosynthesis involves the transformation of steroid precursors to androgens and then conversion of androgens to estrogens by the enzyme ...

THE American Society of Transplant Physicians directed its Patient Care and Education Committee to examine the issue of racial inequality in transplantation. The committee, made up of physicians involved in clinical transplantation, used both published ...

HUMAN immunodeficiency virus type 1 (HIV-1) has been clearly identified as the primary cause of the acquired immunodeficiency syndrome (AIDS).^{1 , 2} Unlike any other infectious disease in modern medical history, AIDS has galvanized the concern and efforts ...

Presentation of Case

A 61-year-old woman was admitted to the hospital after the abrupt onset of paraplegia.

The patient was well until about four months earlier, when she began to experience occasional episodes of mild lumbar pain that came on when she ...

The pathogenesis of psoriasis, which affects approximately 2 percent of the population of the United States and Northern Europe, remains obscure. It is recognized that the disease is genetically determined, but the precise mode of inheritance has not been ...

Breast enlargement in males can be a physiologic or idiopathic phenomenon occurring in newborns, adolescents, and possibly, normal elderly men; it can be the result of a feminizing state, or due to causes unknown.¹ There are many causes of feminizing ...

To the Editor: Dr. Goitein (Aug. 30 issue)* ignores the fact that any increase in the "booking factor" automatically decreases overall access to the physician. For example, if only 20 appointment slots are defined during a given clinic session instead of ...

To the Editor: I believe that Sporik et al. (Aug. 23 issue)¹ overstated the cause for a causal association between exposure to house-dust mite antigen and bronchial asthma. Rather, their data may be largely explained by the established relation between ...

To the Editor: I urge that the conclusions of the short-term study of Mensink and Katan (Aug. 16 issue)¹ suggesting that the effect of trans fatty acids on serum lipid profiles is similar to that of cholesterol-raising saturated fatty acids be ...

To the Editor: Pupita et al. (Aug. 23 issue)¹ have sought to explain myocardial ischemia during exercise in patients with stable angina and single coronary-artery occlusion on the basis of a change in the caliber of collateral or distal coronary ...

To the Editor: The paper by Temkin et al. entitled "A Randomized, Double-Blind Study of Phenytoin for the Prevention of Posttraumatic Seizures" (Aug. 23 issue)¹ is excellent and an important contribution on this subject. Their data suggest, however, that ...

To the Editor: The most characteristic renal parenchymal complication of human immunodeficiency virus (HIV) infection is a focal and segmental glomerulosclerosis that is characterized by severe proteinuria (often in the nephrotic range) and rapid ...

To the Editor: Type II glycogen storage disease (Pompe's disease) is a fatal lysosomal disorder inherited in an autosomal recessive pattern and characterized morphologically by intracellular vacuoles filled with glycogen in several tissues. Since these ...

To the Editor: Advances in medicine capable of sustaining life by artificial means have resulted in continuing legal controversy over such treatment. Media attention has focused on a few highly controversial cases, and legal and medical commentators have ...

This fourth edition of Green's Gynecology, edited by Clarke-Pearson and Dawood, is a comprehensive compendium of current thinking and teaching. An author should write concisely about the subject of his or her expertise and invite effective coauthors to ...

This excellent report addresses the problem of rendering obstetrical care in an increasingly litigious society. It is the product of an interdisciplinary team of 15 experts, headed by Roger Bulger, president of the Association of Academic Health Centers.

...

Women who have too little body fat because of injudicious dieting, intensive exercise, or both, also have delay or disruption of their reproductive ability. I have proposed that this association is causal, and that the large amount of body fat (26–28% of ...

For several years urologic pathology was treated as an orphan in the area of surgical pathology, with few important textbooks available. Fortunately, this is no longer the case, and the past few years have seen the publication of several noteworthy books ...

The field of pathology encompasses an immensely diverse study of the nature of disease. Because of the wide spectrum of human disease, few textbooks have provided a comprehensive review of pathology, addressing issues ranging from cellular mechanisms of ...

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CALL FOR ABSTRACTS

Abstracts are now being accepted for the "2nd International ...

IN November 1986 the Journal published an article by Summers and his colleagues¹ on the use of oral tetrahydroaminoacridine (tacrine, or THA) in the treatment of 17 patients with moderate-to-severe Alzheimer's disease. These workers reported "encouraging ...

More than four years have elapsed since a report by Summers et al. in the Journal described dramatic improvements in patients with Alzheimer's disease treated with tacrine, an investigational acetylcholine esterase inhibitor. These findings led many to ...

To the Editor: The statement from the FDA's divisions of drug evaluation and research is curious.

What this statement omits is noteworthy. The intense 3 1/2-year investigation of our data by a compliance division of the FDA did not abrogate any of our ...