THE growing number of children infected with the human immunodeficiency virus (HIV) makes it imperative that pediatricians rapidly evaluate all potentially useful antiretroviral agents. Zidovudine (formerly azidothymidine, or AZT) decreases morbidity and ...

PATIENTS with congenital adrenal hyperplasia due to 21-hydroxylase deficiency cannot adequately synthesize cortisol, and more than two thirds of them have a parallel block in aldosterone biosynthesis.¹ Inefficient cortisol synthesis results in excessive ...

THE antimalarial drugs hydroxychloroquine, chloroquine, and quinacrine are believed to be effective in controlling lesions of the skin and mucous membranes, as well as the malaise, easy fatigability, arthritis, and pleuritic pain of systemic lupus ...

SINCE it was suggested in 1953 that analgesic drugs could cause chronic renal disease,¹ the relation between prolonged ingestion of such drugs and the development of renal disease has been well studied.^{2 3 4} However, none of the investigations were ...

MAPLE syrup urine disease is a rare inborn error of branched-chain amino acid and branched-chain keto acid metabolism due to decreased branched-chain α-keto acid dehydrogenase-complex activity.¹ The branched-chain keto acids, which are the substrates in ...

IN 1990 breast cancer affected more than 150,000 women in the United States; it will eventually be the cause of death of 25 percent of them.¹ The 1985 Consensus Development Conference on Breast Cancer² and the 1988 Clinical Alert³ affected both the ...

IT has been estimated that the red cells of more than 200 million people are deficient in the enzyme glucose-6-phosphate dehydrogenase (G6PD). This X-linked hereditary deficiency was discovered more than 30 years ago as an outgrowth of studies of the ...

Presentation of Case

A 17-year-old boy was admitted to the hospital because of autoimmune hemolytic anemia and a question of chronic active hepatitis.

The patient was well until 14 months earlier, when symptoms of an upper respiratory tract infection ...

THE history of clinical trials of therapy for systemic lupus erythematosus contains many tales of enthusiastically endorsed treatments that have proved with time to have limited value. Definitive controlled trials, common in evaluating the treatment of ...

ALMOST 25 years ago, Dubach and his colleagues noted that many women working in Swiss watch factories took large amounts of analgesic drugs daily because of occupation-related aches and pains. The relation between abuse of analgesics and renal disease had ...

To the Editor: In his Sounding Board article (June 21 issue)¹ Dr. Levinsky's rhetoric betrays an unfortunate lack of objectivity. He wonders why some scholars show "enthusiasm for eliminating life-saving care for the elderly." In fact, nobody is ...

To the Editor: Aware that more than 100,000 Americans will die of asbestos-related disease,^{1 , 2} the public is understandably suspicious when we conclude that an occupational or environmental exposure is not the cause of a particular ailment. In ...

To the Editor: Thompson et al. (Aug. 16 issue)¹ suggest that Hydergine (Sandoz brand of ergoloid mesylates) is ineffective in treating Alzheimer's disease and may in fact "cause cognitive dysfunction, perhaps through a direct toxic effect or by ...

To the Editor: Menon et al. (Aug. 2 issue)¹ make the interesting observation that animal insulin, mainly in the form of insulin-antibody complexes, can be detected in the cord serum of some infants born to mothers with insulin-dependent diabetes mellitus ...

To the Editor: Studies of the preventive effect of periconceptional multivitamin supplementation on the occurrence of neural-tube defects are conflicting.^{1 2 3 4} In 1965 Hibbard and Smithells suggested a correlation between maternal folate levels during ...

To the Editor: Currently, no single imaging technique reliably detects both primary and metastatic foci of breast cancer.^{1 2 3} We wish to report the feasibility of simultaneously imaging primary and metastatic breast cancer using a whole-body positron-...

To the Editor: Modell and Mountz (Aug. 16 issue)¹ have written a timely article on alcohol abuse by pilots, noting that even small doses of alcohol can have deleterious effects on performance in a job that requires a high degree of precision, vigilance, ...

To the Editor: Concern for the violation of compassionate terminal-care decisions prompted my wife and me to have living wills prepared. The resulting documents seemed cold and fraught with the same dangers that resulted in the Cruzan case. The attached ...

Here, the author has produced a monumental piece of work at a time of life when most of us would be comfortably settled into retirement. A noted psychoanalyst and teacher, Frosch has spent much of his long career writing about severe personality ...

There are two bonuses in this book about the rare condition of eating disorders in men. One is a clinically rich autobiographical account by a patient who was a psychologist, and the second and probably the most valuable and provocative contribution is an ...

Readers drawn to this book because of the catchy title will be disappointed. Although there is an extensive list of 317 references, the authors themselves note that studies of alcohol abuse, violence, and homicide are weak or inadequate in terms of their ...

Harper's Biochemistry began in 1939 as Review of Physiological Chemistry (Los Altos, Calif.: Lange Medical, 1939) and is thus the oldest ongoing textbook in biochemistry. It has undergone periodic rejuvenations; the second edition was published in 1944, ...

The development of enzyme-based immunohistochemical methods, which began more than two decades ago, has had an important influence on the practice of surgical pathology over the ensuing years. The production of monoclonal antibodies to an increasing ...

This collection of essays by persons long associated with the antivivisection movement offers little in the way of fresh perspectives for anyone involved in the issues of animal research, testing, and experimentation. For them, it is just more of the same ...

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MEMORIAL/UCI CENTER FOR HEALTH EDUCATION

The following meetings will take place:...