DURING the past 20 years, there have been major advances in our understanding of the cause of viral gastroenteritis. Rotaviruses in particular, as well as enteric adenoviruses, commonly cause diarrhea in infants and young children, and the Norwalk group ...

PATIENTS with inherited chylomicronemia usually have plasma triglyceride levels above 17 mmol per liter (1500 mg per deciliter) and high-density lipoprotein (HDL) levels of less than 0.52 mmol per liter (20 mg per deciliter) while fasting.¹ They usually ...

HAEMOPHILUS INFLUENZAE type b is the leading cause of meningitis and other serious infections in children.^{1 2 3} The attack rates of this disease among certain Native American populations, such as Alaskan Eskimos, Navajos, and Apaches, are 5 to 10 times ...

AUTOLOGOUS bone marrow transplantation has become a standard form of therapy for patients with recurrent lymphoma. This procedure is associated, however, with a 5 to 15 percent risk of fatal complications. Most patients who undergo autologous bone marrow ...

SCLEROTHERAPY has become an accepted treatment for bleeding esophageal varices. Several randomized clinical trials have demonstrated that sclerotherapy stops variceal bleeding.^{1 , 2} Other studies have shown that sclerotherapy, continued to the point of ...

ALTHOUGH coronary artery disease develops within three years of heart transplantation in up to 40 percent of transplant recipients,^{1 , 2} chest pain late after cardiac transplantation is usually dismissed as being "noncardiac" because it has been assumed ...

SYSTEMIC anaphylaxis represents the most dramatic and potentially catastrophic manifestation of immediate hypersensitivity. This syndrome can affect virtually any organ in the body, although reactions involving the pulmonary, circulatory, cutaneous, ...

Presentation of Case

A 21-year-old man was admitted to the hospital because of a massive pulmonary embolus.

The patient was well until six weeks earlier, when lumbosacral pain developed, became concentrated in the left gluteal area, and subsided after ...

THE article by Stark et al.¹ in this issue of the Journal is an important addition to the evolving understanding of the physiology of the transplanted heart. These investigators have previously used measurements of the myocardial release of norepinephrine ...

This, my last editorial as Editor-in-Chief of the Journal, offers an irresistible opportunity to reflect on what has happened at the Journal during the past 14 years and to speculate about the future.

When I first took this position in 1977 I was daunted ...

DEATHS

Derrick — Charles C. Derrick, M.D., of West Yarmouth, died recently. He was 79.

Dr. Derrick graduated from Rush Medical College in 1939. He was a member of the American Medical Association, the American Geriatrics Society, and the American Society ...

To the Editor: The lessons that Dr. Bailar gleaned from the recent dioxin study by Fingerhut et al. of the National Institute of Occupational Safety and Health (Jan. 24 issue)¹ reached far beyond, and at times contradicted, what the authors presented.² ...

To the Editor: The echocardiographic study of Italian athletes by Pelliccia et al. (Jan. 31 issue)¹ provides unique and valuable information about the effect of nonpathologic workloads on heart size in humans. Because this type of data is not readily ...

To the Editor: Multiple treatment options should be available for patients with symptomatic gallstones — traditional and laparoscopic cholecystectomy, oral bile acids, biliary lithotripsy, contact dissolution agents, and percutaneous cholecystolithotomy. ...

To the Editor: Since its first description in the Journal,¹ myocarditis in patients with rabies has been suspected to be due to direct infection of the heart with the virus. The description of Negri bodies in cardiac neurons² and the transmission of the ...

To the Editor: Thyroid dysfunction is often accompanied by mood disturbances.¹ Postpartum thyroid dysfunction and postpartum depression occur frequently; the peak incidence of both conditions occurs two to five months post partum.^{2 3 4} We examined ...

To the Editor: Benign partial epilepsy with centrotemporal spikes on electroencephalography is probably inherited by way of a single autosomal dominant gene.^{1 2 3} In some cases of epilepsy in which valproate is clinically efficient, the drug often ...

To the Editor: Congratulations to Birch et al. (Jan. 24 issue)¹ for confirming that normal children, presented with healthful food choices and left to their own devices, will not starve to death. On reflection, however, these findings should come as no ...

Among the most sensitive tasks of our courts of law is dealing with disputes among parents over the best interests of children.¹ The Illinois Supreme Court was recently faced with an unusual case in which one of the parties to such a dispute was a father ...

Here, the enfant terrible of the Freud Archives tells of his distempered and disillusioned encounter with psychoanalysis. Dr. Masson is known for his controversial book, The Assault on Truth: Freud's Suppression of the Seduction Theory (New York: Farrar, ...

This book is an addition to the group of highly distinguished monographs entitled the Johns Hopkins Series in Contemporary Medicine and Public Health. At first, the terms "hysteria" and "contemporary" seem contradictory. After all, hysteria is no longer ...

The authors of this book explore details of the modern-day treatment of alcoholism, using a naturalistic design. They contrast this with previous studies that considered pretreatment factors and outcome but left the treatment process itself as a "black ...

Madness has always been a subject of intrigue. Learned philosophers, theologians, and psychiatrists have struggled to explain its origins. The cause of madness has been attributed to forces as dark as demons and devils, and insanity has been viewed as a ...

Here is a comprehensive review of the pathophysiology, prevention, and management, both pharmacologic and nonpharmacologic, of migraine headaches. The book is divided into 11 chapters dealing with the diagnosis, pathophysiology, and treatment of migraine ...

This work is a multiauthored textbook that addresses bacterial meningitis in detail, with chapters on pathophysiology, epidemiology, diagnosis, and various causative agents. There are discussions of neonatal, fungal, tuberculous, and chronic meningitis; ...

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CALL FOR ABSTRACTS

Abstracts are now being accepted for the "International ...

ON June 12, 1991, the Institute of Medicine of the National Academy of Sciences released a report delineating a national agenda for research on aging.* In this report, a committee of 18 national leaders in health care identified national priorities for ...