CONSIDERABLE attention has recently been focused on the molecular pathophysiology of bacterial meningitis in an attempt to elucidate the mechanisms of meningeal inflammation and the ways they can be regulated to improve outcome for patients with the ...

THE continuous administration of beta-adrenergic—antagonist drugs induces a sustained decrease in portal pressure in patients with cirrhosis.^{1 2 3 4} As a result, these drugs have been used to prevent gastrointestinal bleeding, a leading cause of death in ...

CHRONIC obstructive lung disease causing hypoxemia leads to the development of pulmonary hypertension and cor pulmonale.¹ The prognosis of cor pulmonale is determined by the severity of the pulmonary hypertension.² However, the manner in which prolonged ...

PRIMARY biliary cirrhosis is a chronic cholestatic liver disease of unknown cause, most often diagnosed in middle-aged women. Morphologically, primary biliary cirrhosis is characterized by portal inflammation and necrosis of biliary cells in the small and ...

The treatment of brain tumors usually begins with surgery for diagnosis or excision. Subsequent comprehensive care may involve cooperation between neurosurgeons, neurologists, neuroradiologists, neuropathologists, radiation therapists, and oncologists. ...

HEPARIN was discovered in 1916 by McLean,¹ who as a medical student was looking for a coagulant in the liver. In 1939, Brinkhous and associates² demonstrated that the anticoagulant activity of heparin requires a plasma cofactor (that they called heparin ...

Presentation of Case

A 15-year-old boy was admitted to the hospital because of fever of unknown origin, anemia, and weight loss.

The boy was well until 40 days earlier, when he experienced the sudden onset of pain in the right upper abdominal quadrant, ...

As medicine has become increasingly scientific and less accepting of unsupported opinion or proof by anecdote, the randomized controlled clinical trial has become the standard technique for changing diagnostic or therapeutic methods. The use of this ...

Biomedical research leads to better understanding of biology and ultimately to improved health. Physicians have for millenniums attempted to understand disease, to use this knowledge to cure or palliate, and to relieve attendant suffering. Improving ...

To the Editor: In his editorial "Searching for the Yeast Connection" (Dec. 20 issue),¹ Bennett noted, "The study by Dismukes et al. [Dec. 20 issue²] was carefully designed and the data thoughtfully analyzed." Yet, Bennett also said that this study "is ...

To the Editor: The article by Mangano et al. (Dec. 27 issue)¹ is an important contribution to the accumulating evidence that the detection of an ST-segment shift in the perioperative period is of prognostic value in predicting the immediate and even long-...

To the Editor: Serruys et al. (Jan. 3 issue)¹ reported on the angiographic follow-up of 105 stainless-steel, self-expanding stents (Wallstent) placed in the coronary arteries of 95 patients. Complete occlusion of 27 stents in 25 patients was observed. ...

To the Editor: We recently cared for a newborn infant who, to our knowledge, may be the smallest (birth weight, 280 g [9.9 oz]) survivor ever described.¹ She is now 18 months of age.

The mother is 36 years old and this has been her only pregnancy. ...

To the Editor: Cranberry juice is widely recommended, particularly in the United States, for the treatment of urinary tract infections. The beneficial effects of the juice have been attributed to its hippuric acid content, although there is no scientific ...

To the Editor: As a busy practicing neurologist I review many scans of the cervical spine obtained by magnetic resonance imaging in my patients. I would like to correct an error that I noticed in Case 1–1991 in the January 3 issue of the Journal.*

Figure ...

To the Editor: We recently encountered a previously undescribed complication associated with an automobile air-bag malfunction. A two-year-old boy had been an unrestrained passenger in a two-car motor vehicle accident and was thrown from the rear seat to ...

Part of the training process in medicine is coming to grips with uncertainty. At some point each student realizes that a surprisingly large number of clinical situations pose questions for which there is no single best answer. Since such uncertainty does ...

As you would expect from the impressive list of authors, this book is an excellent resource. It certainly does not follow the usual lines of pharmacology textbooks, and that is what makes it so useful. The organization of the book can best be understood ...

Difficult Medical Management focuses on 93 clinical problems selected because they present important challenges in treatment. In addition to traditional topics in adult medicine, such as osteoporosis and acute myocardial infarction, there are chapters on ...

This is the first edition of a new comprehensive textbook of endocrinology. Succinct, clearly written chapters have been contributed by recognized authorities and are logically organized into sections devoted to the major endocrine organs, with thorough ...

This book on basic dermatology is intended for primary care physicians. The author notes that about 15 percent of all visits to general practitioners involve skin lesions. The book is comprehensive, briefly defining rare skin disorders in the dictionary—...

It is abundantly clear that we need better treatment for rheumatoid arthritis. The drugs that we use provide good symptomatic relief but do not retard joint destruction. Rheumatologists' management of rheumatoid arthritis (and other connective-tissue ...

This book offers a refreshing and novel approach to the interpretation of hematologic signs in systemic disease. As such, it complements traditional books and reframes familiar problems by discussing them across disease categories.

The book is current and ...

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NATIONAL LEAGUE FOR NURSING

The 20th biennial convention, entitled "Toward a ...