A MYOTROPHIC lateral sclerosis, often referred to as Lou Gehrig's disease, motor neuron disease, or Charcot's syndrome, is a devastating paralytic disorder with onset in adulthood, caused by degeneration of large motor neurons of the brain and spinal ...

ACUTE promyelocytic leukemia makes up approximately 15 percent of the adult acute nonlymphoblastic leukemias.¹ The disease is associated with a specific cytogenetic abnormality, the translocation of a portion of the long arm of chromosome 17 onto the long ...

CHRONIC respiratory alkalosis is a common acid–base disturbance characterized by a primary and sustained decrease in arterial carbon dioxide tension (PaCO₂) — that is, by primary hypocapnia. A decrease in PaCO₂ occurs when the effective alveolar ...

ETHYLENE OXIDE is a gas used as a chemical intermediate; since the 1950s it has also been used to sterilize medical supplies and other materials. The National Institute for Occupational Safety and Health (NIOSH) estimates that approximately 270,000 ...

VARIEGATE porphyria is an autosomal dominant disorder characterized clinically by attacks of neurologic dysfunction, photocutaneous lesions, or both. The symptoms that occur during attacks, chiefly abdominal pain, are identical to those of acute ...

SURVIVAL after a diagnosis of the acquired immunodeficiency syndrome (AIDS) is influenced by a number of factors. Early studies of persons given a diagnosis of AIDS before antiretroviral therapy became available suggested that age, the AIDS-defining ...

RHABDOMYOLYSIS is a common syndrome in which injury to skeletal muscle results in the leakage of the contents of myocytes into the plasma. It can be induced by numerous factors, including a crush injury to a limb, overuse of skeletal muscle, heat, ...

Presentation of Case

A 62-year-old woman was admitted to the hospital because of progressive obstruction of the left nasal cavity by a mass.

There was a 14-year history of seasonal allergic rhinitis associated with intermittent nasal obstruction; ...

The total human genome is estimated to contain on the order of 3 billion base pairs. Ninety to 95 percent of the genome has no known function and is often referred to as "junk DNA." The remaining 5 to 10 percent contains approximately 50,000 to 100,000 ...

The term "porphyria" refers to a group of diseases characterized by the excessive production and excretion of porphyrins, porphyrin precursors, or both. Each of the diseases is due to a specific enzymatic defect in the heme biosynthetic pathway, and in ...

To the Editor:... Although there may be situations in which physician-assisted suicide is ethically acceptable (an arguable proposition to begin with), the law must not be seen to sanction conduct such as occurred in the back of Dr. Kevorkian's van (...

To the Editor: Swinnen et al. (Dec. 20 issue) reported an 11.4 percent incidence of post-transplantation lymphoproliferative disorder associated with the administration of OKT3 in heart-transplant recipients.¹ This experience is not consistent with that ...

To the Editor: In the case presentation in the April 19, 1990, issue,¹ Drs. Wolpow and Mark provided valuable insights into the diagnosis and treatment of brain abscess and pulmonary arteriovenous malformations, except that treatment of the latter with ...

To the Editor: Lyme borreliosis is a systemic disorder caused by Borrelia burgdorferi, a tick-borne spirochete. The infection frequently causes neurologic problems, but the causative agent has rarely been isolated from cerebrospinal fluid,^{1 , 2} because ...

To the Editor: A review of the neuropathology records at the Massachusetts General Hospital revealed that since 1985, three ophthalmologists had been hospitalized for histopathologically confirmed intracranial glioblastoma multiforme (grade IV or IV ...

To the Editor: Swedo et al. reported that clomipramine is effective in the treatment of trichotillomania and speculated that this illness, currently classified as a disorder of impulse control, may instead be a form of obsessive—compulsive disorder.¹ A ...

To the Editor: Your Special Article about New York State's UNY-Care initiative (Sept. 6 issue)¹ provides an opportunity to assess the initiative against the criteria of the American College of Physicians for reforming the system to provide universal ...

To the Editor: The World Health Organization estimates that more than one third of the 8 million persons infected with the human immunodeficiency virus (HIV) worldwide are women. In the United States alone, the number of women with the acquired ...

Clinical Anesthesia

Edited by Paul G. Barash, Bruce F. Cullen, and Robert K. Stocking. 1575 pp., illustrated. Philadelphia, J.B. Lippincott, 1989. $129.95.

General Anaesthesia

Fifth edition. Edited by J.F. Nunn, J.E. Utting, and Burnell R. Brown, Jr. 1433 ...

The author evidently conceived of this work as providing anesthesia residents with a better understanding of the physiologic and pharmacologic principles essential to formulating effective and rational clinical strategies. The book arose from the ...

During the past decade the American Society of Anesthesiologists, especially the Closed Claims Subcommittee, has striven to reduce morbidity and mortality in the perioperative period. This excellent book successfully complements the society's efforts in a ...

Here is an excellent introductory textbook for cardiac anesthesiologists, cardiac surgeons, intensivists, and perfusionists. The most appreciative readers will be those receiving a new or renewed exposure to the cardiac surgical operating suite and facing ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

CARDIOVASCULAR ANGIOGENESIS

The "14th Annual Page Lecture" will be given in ...

Combined-Modality Therapy for Rectal Carcinoma — The Time Has Come (March 14, 1991; 324:764–6). On page 766, in the left-hand column, the sentence that begins in the second line should have read, "Trials in progress should soon determine how many patients ...

Regional Myocardial Metabolism of High-Energy Phosphates in Patients with Coronary Artery Disease (April 25, 1991; 324:1218–9). On page 1219, Robert G. Weiss, M.D., from Johns Hopkins Hospital in Baltimore, Maryland, should have been listed as an author. ...