FROM the work of Keys¹ we know that populations whose diet is high in saturated fats have a higher incidence of atherosclerosis than populations eating a diet rich in unsaturated or polyunsaturated fats. Only recently, however, has it become clear that ...

END-STAGE renal disease is one of the most common complications of diabetes mellitus, particularly in patients with insulin-dependent (Type I) diabetes. Although blood glucose control and aggressive management of coexisting hypertension can slow the ...

THE origin and pathogenesis of inflammatory bowel disease remain an enigma. The reported increase in the incidence of Crohn's disease has been attributed to environmental factors, including bacterial or viral infection; however, no such factors have been ...

RHODOCOCCUS species are gram-positive bacillary aerobic actinomycetes found in soil, sewage, fresh water, and feces of horses, sheep, and cattle.^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23} Only one report of Rhodococcus (Gordona) ...

LEGIONELLA is generally regarded as a pulmonary pathogen and has been responsible for numerous outbreaks of pneumonia in both community and hospital settings.^{1 2 3 4 5 6 7} Although isolated cases of extrapulmonary legionella infection have been reported,⁸ ...

IN this paper we describe the legal system for dealing with malpractice claims in Canada, contrasting it with that in the United States and suggesting reasons for the dramatically different liability costs imposed on physicians. Despite a lower frequency ...

RESEARCH into the neuroendocrine control of reproduction by gonadotropin-releasing hormone (GnRH) has witnessed a remarkable two decades. From the isolation and chemical characterization of GnRH in 1971 through the awarding of the Nobel Prize to Drs. ...

Presentation of Case

A 60-year-old woman was admitted to the hospital after two seizures.

The patient was well until 1 1/2 years earlier, when arthralgia developed and she consulted a rheumatologist. The erythrocyte sedimentation rate was 74 mm per hour; ...

IN this issue of the Journal, Smal¹ et al.¹ provide instructions for reducing the cholesterol content of red meat and partially replacing its natural fat with vegetable fat. This delightful lesson in food composition appears against a background of recent ...

"MY most cordial thanks for having, by your brilliant researches, demonstrated to me the truth of the germ theory of putrefaction, and thus furnished me with the principle upon which alone the antiseptic system can be carried out."¹ Thus did Joseph Lister ...

To the Editor: The review of the biology and management of bladder cancer by Raghavan et al. (April 19 issue)¹ did not address two major areas of investigation that should be of interest to investigators reviewing bladder cancer. The first concerns an ...

To the Editor: Paterlini et al. (July 12 issue)¹ reported the use of the polymerase chain reaction to detect hepatitis B virus (HBV) DNA and RNA sequences in primary liver cancers of subjects negative for hepatitis B surface antigen (HBsAg). Two of the ...

To the Editor: Reihnér et al. (July 26 issue)¹ should be commended for their interesting study and their methodologic groundwork.^{2 , 3} It would be premature, however, to draw conclusions about the relative quantitative roles of inhibition of cholesterol ...

To the Editor: In the review article by Anderson and Weinstein (Aug. 2 issue),¹ sharing one HLA haplotype is postulated as a risk factor for the development of transfusion-associated graft-versus-host disease. However, no mention is made of the ...

To the Editor: In their paper in the July 26 issue,¹ Steere et al. state in the Results section that the frequency of HLA-DR4 was significantly greater in patients with chronic arthritis than in normal subjects (57 vs. 31 percent, P<0.01). This statement ...

To the Editor: In April 1990 the Centers for Disease Control¹ revised their recommendations for malaria prophylaxis for travelers to areas where chloroquine-resistant Plasmodium falciparum is endemic to make mefloquine (Lariam), a 4-quinidine-methanol ...

To the Editor: Delayed gastric emptying is a well-documented late manifestation of diabetes mellitus that is usually attributed to autonomic neuropathy.^{1 , 2} Gastric emptying has been studied in heterogeneous groups of patients with insulin-dependent ...

To the Editor: Bianco and colleagues (Oct. 19, 1989, issue)¹ reported that furosemide, when given as an aerosol, can prevent the early and late responses induced by allergen. The mechanism whereby furosemide protects the airways in response to allergen ...

To the Editor: I thoroughly enjoyed the two-part review article on echocardiography by Popp (July 12 and 19 issues).¹ It should be noted, however, that there is a mistake in the second part of the article. Under the heading "Infective Endocarditis" (p. ...

To transform the prodigious body of research on almost any aspect of the acquired immunodeficiency syndrome (AIDS) into a timely, coherent book requires an act of editorial alchemy. The editors of this book have undertaken a substantial transforming act ...

This is a terrific little book. While the editors have done an outstanding job of compiling authoritative reviews of all important aspects of AIDS, what makes this book particularly valuable is its timeliness. Miraculously, the book has been published six ...

The author is director of the Division of Laboratory Systems (Division of Training) at the Centers for Disease Control. As do many on the front lines of the fight against AIDS, he sees the task of AIDS prevention as primarily one of education in the ...

With his long history of working with the problem of cancer, Raven presents a unique review of the history of oncology, with some added chapters relating to the current practice of treating cancer. The book is especially valuable for its historical ...

I like this book. The informative introduction underscores the need for ethics, integrity, and empathy in the approach to patients with cancer. This edition is organized like its predecessors, into major sections — principles of cancer therapy, site-...

In the preface, the editor of this comprehensive work on the spleen provides a historical overview of the studies that have brought us to the current state of our understanding of splenic structure and function. He concludes that the timing is right for a ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

ST. LOUIS UNIVERSITY SCHOOL OF MEDICINE

The following courses will be offered:...

The New Technology Assessment (September 6, 1990; 323:673–7). The second author, Alan M. Garber, M.D., Ph.D., should also have been listed as being affiliated with the Palo Alto Veterans Administration Center in Palo ALto, California.