THE prognosis in patients with aplastic anemia has improved substantially with the introduction of treatment with bone marrow transplantation and antilymphocyte serum. The long-term survival of patients with severe disease has increased from less than 25 ...

THE role of the kidney as a long-term regulator of blood volume and blood pressure is well established.¹ Any increase in blood pressure is compensated for by an increase in the renal excretion of water and salt. During the development of hypertension, the ...

THE identification and surgical closure of muscular ventricular septal defects, particularly those that involve the trabeculated portion of the ventricular septum, are known to be difficult.^{1 2 3 4 5 6 7 8} Improved angiographic diagnosis and surgical ...

THE oculocerebrorenal syndrome of Lowe is an X-linked recessive disorder mapped to Xq24—26^{1 , 2} and characterized by congenital cataracts, cognitive impairment, and renal tubular dysfunction (Fanconi's syndrome).³ Additional clinical features include ...

HIP fracture is the most serious consequence of osteoporosis. More than 90 percent of such fractures occur in persons over 70 years of age.^{1 , 2} The dramatic age-related increase in rates of hip fracture is widely believed to result primarily from ...

ORGANISMS of the Mycobacterium avium complex have long been recognized as an uncommon cause of pneumonia in persons with chronic lung disease.^{1 2 3 4} Organisms of this complex, which comprises two closely related species, M. avium and M. intracellulare, ...

THE red-cell mass is continuously adjusted to the optimal size for its function as an oxygen carrier by messages transmitted to the bone marrow from an oxygen sensor in the kidney. These messages are mediated by the hormone erythropoietin, are modulated ...

Presentation of Case

An 80-year-old woman was admitted to the hospital because of increasing dyspnea, a cough, and an abnormal x-ray film of the chest.

The patient was in a stable state of health until 10 months earlier, when stiffness and aching ...

Mathé et al. reported in 1970 that when some patients with aplastic anemia received an allogeneic marrow transplant together with a conditioning immunosuppressive regimen of antilymphocyte globulin, they recovered autologous hematopoietic function.¹ ...

The introduction 30 years ago of hemodialysis as a widely used treatment for renal disease began a classic cycle of good news and bad news. On the bright side, vast numbers of people with life-threatening kidney failure had their lives miraculously ...

Because of the growing focus on containing health care costs, pharmaceutical companies are trying to demonstrate the cost effectiveness of their products relative to alternatives. In Europe and Australia, economic analyses are often required for ...

DEATHS

Baker — Philip Woodell Baker, M.D., of Chazy, N.Y., died on February 21 at the age of 85.

Dr. Baker received his degree from Harvard Medical School in 1931.

MA — David I. Ma, M.D., of Weston, died on March 8. He was 31.

Dr. Ma received his degree ...

To the Editor: In their Sounding Board article (Dec. 6 issue),¹ which discusses the role of the physician in detecting and reporting, but not following up, cases of child abuse, Jellinek et al. suggest the need for child advocates who would, presumably, ...

To the Editor: In Harris and Sledge's review of total hip and total knee replacement (Sept. 13 and 20 issues),¹ I was disappointed that the discussion of the complications of deep venous thrombosis and pulmonary embolism did not include a more thorough ...

To the Editor: High-dose immunoglobulin therapy has been shown to be a successful treatment for patients with pure red-cell aplasia.^{1 , 2} We confirmed these results in two adult patients, one of whom has been in complete remission for more than 42 months ...

To the Editor: Treatment with recombinant human erythropoietin can reverse the anemia of renal failure.^{1 , 2} In sickle cell anemia, the anemia is rarely severe enough to merit transfusion. The need for transfusion may arise acutely, or occur in patients ...

To the Editor: In a letter in the April 19, 1990, issue,¹ Egli et al. reported an interesting association between glucose-6-phosphate dehydrogenase (G6PD) deficiency and hairy-cell leukemia and suggested that a locus on the X chromosome might be involved ...

To the Editor: Recently, laparoscopic cholecystectomy has had a marked effect on surgical practice.¹ However, laparoscopic technology has not been applied to larger solid organs because of the lack of appropriate instrumentation and techniques.² We ...

To the Editor: Dr. Salman includes a discussion of "polymorphic reticulosis" in the differential diagnosis of a patient with maxillary sinus opacification (Jan. 11, 1990, issue).¹ He also notes that "lethal midline granuloma" is a term previously used ...

To the Editor: The article by Hillman et al. on the frequency and costs of diagnostic imaging in office practice (Dec. 6 issue)* did find that physicians who own their own equipment perform more radiography than those who refer patients to radiologists, ...

To the Editor: Walking through a pane of glass is a shattering experience. I wish to draw attention to the psychological effect and international dimensions of this problem.

I was walking through a hotel lobby to join colleagues at a restaurant. They ...

Biomedical Science

Advances in Pineal Research. Vol. 4. Edited by Russel J. Reiter and Andrzej Lukasyzk. 278 pp., illustrated. London, John Libbey, 1990. $63.

Animal Virus Pathogenesis: A practical approach. Edited by Michael B. A. Oldstone. 174 pp., ...

The second edition of this manual of therapeutic endoscopy and radiology exemplifies the close cooperation that has developed over the past decade between gastrointestinal endoscopists and radiologists. The purpose is to provide succinct and topical ...

Flexible fiberoptic endoscopes have led to a revolution in gastroenterology. While learning the technique of gastrointestinal endoscopy mainly involves acquiring hands-on experience under the direct supervision of an experienced endoscopist, there is a ...

Perhaps no other technical advance in the field of gastroenterology has as dramatically changed the standard of care as the fiberoptic endoscope. For the surgical pathologist, it has created a new class of diagnostic biopsies. Endoscopic biopsies now ...

These two fine but different books provide as much a stimulus for a brief meditation on book publishing in the 1990s as an occasion for specific review. The first book is the second edition of an established compendium on inflammatory bowel disease; the ...

Based primarily on material from the Tufts University Diet and Nutrition Letter, this attractive book is aimed at readers with no scientific background. Its objective is to provide the public with a reliable, common-sense guide to nutrition. The book ...

This is the first edition of a textbook on general and systemic pathology written for second-year medical students. It is the experience of the authors that students in the pathology course rarely have time for additional reading beyond the course ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

NEUROSCIENCE OF HIV INFECTION

The conference, subtitled "Basic and Clinical ...

High-Dose Intramuscular Triamcinolone in Severe, Chronic, Life-Threatening Asthma (February 28, 1991; 324:585–9). On page 587, in the left-hand column, first full paragraph, 10th line, the phrase "360 mg of triamcinolone is equivalent to 300 mg of ...

Abnormalities of Lipoprotein Metabolism in the Nephrotic Syndrome (March 7, 1991; 324:697–8). On page 697, in the left-hand column, the sentence that begins in the 17th line of the first paragraph should have read, "The drugs that inhibit the activity of ...