ALTHOUGH up to 40 percent of cardiac arrests L have been reported to be successfully reversed in selected series of patients,¹ more than half of resuscitated patients die during hospitalization,^{2 , 3} many because of ischemic brain damage.^{3 , 4} ...

Phenylketonuria is an autosomal recessive genetic disease caused by a deficiency of hepatic phenylalanine hydroxylase activity. The various degrees of mental impairment that occur in patients with phenylketonuria can be reduced through the rigorous ...

IN recent years, economic pressure on the health care system has intensified interest in using risk stratification to increase efficiency in the care of patients with suspected acute myocardial infarction.¹ To avoid the initial triage to coronary care ...

RECENT studies have indicated that most infants with neonatal herpes simplex virus (HSV) have mothers with subclinical genital HSV infection with asymptomatic shedding of the virus at the time of delivery.^{1 2 3 4 5 6 7} Not all infants exposed to HSV at ...

Lisch nodules are melanocytic hamartomas that appear as well-defined, dome-shaped elevations projecting from the surface of the iris and are clear to yellow or brown. Multiple Lisch nodules appear to be found only in patients with peripheral ...

Medicine is increasingly a spectator sport. Doctors, patients, and nurses perform before an enlarging audience of utilization reviewers, efficiency experts, and cost managers (Fig. 1). A cynic viewing the uninflected curve of rising health care spending ...

PATIENTS with life-threatening injuries make up approximately 10 to 15 percent of all patients hospitalized because of injuries.¹ Some authors have defined patients with extensive trauma as those with injury severity scores (ISSs) higher than 15 (for an ...

Presentation of Case

A 70-year-old man with treated lymphoma was admitted to the hospital because of fever and weakness.

The patient was well until 16 years earlier, when a periumbilical mass developed. Medical evaluation at another hospital, including a ...

The report in this issue of the Journal on the large international study by the Brain Resuscitation Clinical Trial II Study Group¹ describing the ineffectiveness of the calcium-channel blocker lidoflazine in reducing either mortality or brain damage after ...

Phenylketonuria contributes to our acceptance of a model of disease that relates the manifestations (phenotypes) of a disease to an underlying process (pathogenesis) that has its origin in a cause (which may include a variant genotype). Our knowledge of ...

Medical decision making in patients who present with chest pain or other symptoms suggestive of acute coronary disease continues to evolve amid new forms of technology and treatment, limitations on resources, and substantial local variation in the number ...

Ten years ago, the Journal published my review of von Recklinghausen neurofibromatosis,¹ now aptly called neurofibromatosis 1. In that article, I emphasized a previously arcane feature of the disorder, for which a new term was coined: "Lisch nodule." When ...

To the Editor: We examined the relation between the presence and absence of siblings and hypertension in 1472 whites (676 men and 796 women) who participated in the Buffalo Blood Pressure Study conducted in 1961 on a random sample of households in the ...

To the Editor: Murphy and colleagues (Dec. 13 issue)* have provided useful information about long-term survival in patients who have undergone repair of an atrial septal defect. The authors suggest that patients should be reassured about their ...

To the Editor: Manning et al. (Dec. 20 issue)¹ elegantly demonstrated that pretreatment with MK-571, a selective leukotriene D₄—receptor antagonist, markedly attenuated exercise-induced bronchoconstriction in patients with asthma. However, we have some ...

To the Editor: Heijboer et al. (Nov. 29 issue)* found few deficiencies of antithrombin III, protein C, protein S, or plasminogen in their patients with deep-vein thrombosis. However, the deficiencies found in the control group were also much fewer than ...

To the Editor: Feldman and Burton state in their excellent review that histamine₂-receptor antagonists may interact with other drugs by altering their clearance or absorption. Their paper contained a table (Table 5) listing some important interactions ...

To the Editor: Liver damage in primary human herpesvirus-6 infection has been reported in infants^{1 , 2} and adults.^{3 4 5} All patients had a benign, self-limited course except one infant with fatal fulminant hepatitis.¹ We describe here an adult with ...

To the Editor: Dr. Newcomer (Dec. 13 issue)¹ is to be commended for grappling with the dilemma of experimental therapy and the question of who should pay for it. Unfortunately, his careful analysis avoids stating directly the real definition of "...

This serious but often humorous book is a guide for laypersons to the limitations and pitfalls of medicine and public health. It provides information essential to understanding why otherwise intelligent people, including physicians, can be entrapped by ...

The appropriate care of the pregnant woman and her fetus requires a thorough understanding of the science of medicine, the patient's needs, and the current social and medicolegal climate. Standard textbooks of obstetrics have addressed the science of ...

Those who wish quantitative and qualitative information about important afflictions of the young will find this a remarkable overview. Here is the doyen of books on ambulatory pediatrics, a discipline that has also become known as general pediatrics. ...

It has been seven years since the fourth edition of Kendig's Disorders was published. The fifth edition of this textbook of pediatric lung diseases is a comprehensive, multiauthored book with seven new chapters, 28 new contributors, a larger format, and ...

There is probably no area of pediatric medicine more discomforting to physicians caring for children than that involving the metabolism of calcium, phosphate, and vitamin D and metabolic bone disease. This opinion is based on my personal struggles, as ...

The publication of the first edition of this book in 1974 was a major event. That edition heavily emphasized the role of basic pathophysiologic science in neurologic disease and daringly omitted the previously obligatory chapter on the pediatric ...

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AIDS

The 7th international conference will be held in Florence, Italy, June 16–...

Reduced Allergen-Induced Nasal Congestion and Leukotriene Synthesis with an Orally Active 5-Lipoxygenase Inhibitor (December 20, 1990; 323:1745–8). On page 1746, in the right-hand column, in the 11th line under the heading "Nasal Mediator Release," the ...

Common Solid Tumors of Childhood (February 14, 1991; 324:461–71). In Table I the estimated total number of cases of pediatric solid tumors for 1991 and the annual rate per million in children with cancer (1985–1987) have been corrected and updated to read ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...