FIBROSIS is an important component of advanced chronic inflammatory liver disease.^{1 2 3 4 5} In cirrhosis, fibrosis is accompanied by cell necrosis and nodular regeneration.^{2 , 3} Hepatic fibrosis is a complex process that involves changes in the amounts of ...

NUMEROUS prospective studies have documented that higher serum cholesterol levels are associated with an increase in subsequent morbidity and mortality from coronary heart disease.^{1 2 3 4 5 6 7 8} Clinical trials of agents that lower cholesterol levels ...

HYPERTHYROIDISM in patients with Graves' disease is due primarily, if not solely, to the production of autoantibodies that bind to receptors for thyroid-stimulating hormone (TSH) on thyroid cells.^{1 2 3 4} These anti—TSH-receptor antibodies are formed ...

HUMAN immunodeficiency virus type 1 (HIV-1) causes the acquired immunodeficiency syndrome (AIDS),^{1 2 3} a chronic illness characterized by progressive immune and neurologic dysfunction. HIV-1 also causes an acute viral syndrome⁴ with variable ...

PRIMARY infection with the human immunodeficiency virus type 1 (HIV-1) associated with seroconversion is most commonly manifested as an acute illness characterized by fever, myalgia, rash, gastrointestinal symptoms, and at times neurologic complications.¹ ...

ADVERSE reactions to cow's milk have been estimated to occur in 0.1 to 7.5 percent of children.^{1 , 2} A variety of manifestations have been reported, including urticaria, angioedema, atopic dermatitis, rhinitis, wheezing, anaphylactic reactions, various ...

OMEPRAZOLE is the first of a new class of drugs that inhibit gastric secretion by altering the activity of H+/K+—ATPase,^{1 2 3} the final common step of acid secretion, in gastric parietal cells. The discovery of omeprazole has led to new insights into the ...

Presentation of Case

A 17-week-old boy was admitted to the hospital because of a thoracic mass.

The child was born after a full-term pregnancy by an elective cesarean section at another hospital. His birth weight was 4.1 kg. The Apgar scores were 7 at one ...

THE management of chronic liver disease, particularly cirrhosis, has focused primarily on treating and preventing the complications of portal hypertension. Unfortunately, there is no therapy that has been proved to prevent progressive hepatic fibrosis or ...

ALL three current treatments for hyperthyroidism caused by Graves' disease are remarkably effective. When prescribed properly and taken faithfully, the thionamide antithyroid drugs control hyperthyroidism in almost all patients. Radioactive-iodine therapy ...

Emerson — Charles Phillips Emerson, Jr., M.D., of Wellesley Hills, died on January 23 at the age of 78.

Dr. Emerson graduated from Harvard Medical School in 1937. He was a member of the American Medical Association, the American Federation for Clinical ...

To the Editor: Grobbee et al. (Oct. 11 issue)¹ claim that their data do not support the hypothesis that coffee consumption increases the risk of coronary heart disease. They fail to make the distinction between evidence against the hypothesis and a lack ...

To the Editor: We read with concern the review article entitled "Treatment of Hypertensive Crisis," by Calhoun and Oparil (Oct. 25 issue),¹ wherein the authors advocate sodium nitroprusside as "the preferred agent" to lower blood pressure in patients ...

To the Editor: The article by Fischl et al. (Oct. 11 issue)* is a very important contribution to the literature on the use of zidovudine in patients with the acquired immunodeficiency syndrome (AIDS). The data presented have already substantially ...

To the Editor: The transmission of blood-borne diseases such as HIV infection and hepatitis B often occurs in a chain from person to person. The accidental or deliberate reuse of unsterilized needles or syringes is a critical link in the chain. The ...

To the Editor: There have been an increasing number of reports of isolates of non—β-lactamase-producing Neisseria meningitidis for which the minimal inhibitory concentrations of penicillin were ≥0.25 mg per liter.¹ These isolates of penicillin-...

To the Editor: The interesting report by Kuritzky (Nov. 15 issue)¹ of successful treatment of retinal-artery thrombosis in a 64-year-old woman by means of sublingual nitroglycerin raises a question about the mechanism by which such treatment might be ...

To the Editor: Observations that the proportion of left-handers in the population decreases substantially with age (diminishing from 13 percent in 20-year-olds to less than 1 percent in 80-year-olds^{1 , 2}) have led to the suggestion that sinistrality may ...

MUCH has been written in recent years about the property interests of patients in commercial products developed from human cell lines.^{1 2 3 4} Most of these commentaries have been rendered obsolete by a recent ruling of the Supreme Court of California. In ...

This book provides an introduction to the pathophysiologic principles underlying disorders of the nervous system and is intended primarily for medical students. The author successfully relates the recent advances of neuroscience to our understanding of ...

The study of Parkinson's disease has been one of the most fruitful areas in neurology over the past 30 years. The discovery in the 1960s of nigrostriatal dopamine deficiency and levodopa therapy substantially improved the lives of many patients with ...

The care of patients with spinal injuries is a multidisciplinary endeavor involving orthopedic surgeons, neurosurgeons, radiologists, anesthesiologists, and rehabilitation specialists. As the sophistication of these disciplines increases, each specialist'...

In a foreword, Hanno Millesi states that "anyone interested in peripheral-nerve surgery will find this volume to be a concise source of information written by masters in the field." While this statement is true, it fails to specify that the book is more ...

During the past 25 years, the entire subject of trigeminal neuralgia has been completely reevaluated. This disease, marked by one of the worst pains that can be experienced, is survivable only because of the brevity of the individual spasms. Virtually no ...

This comprehensive textbook of electroencephalography and evoked potentials, in addition to the expected topics, includes chapters on long-term intracranial recording and electrocorticography, sleep disorders, intraoperative monitoring, and the use of ...

This is the latest in a series of surgical atlases by Seeger. Its format follows those of the earlier books, with drawings and comments on the right-hand page and additional explanatory text opposite. The book begins with details on the separation of two ...

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Integrative Psychiatry, the official journal of Academia, ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 9, 1991, issue of the British Medical Journal and the February 7, 1991, issue of the New ...