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March 21, 1991  Vol. 324 No. 12

Original Articles
781-788

VENTRICULAR premature depolarizations are a risk factor for sudden and nonsudden cardiac death after myocardial infarction1 and are often treated with antiarrhythmic drugs.2 Ventricular arrhythmia and left ventricular dysfunction have been found to be ...

788-794

PHYSICIANS who treat patients with acute asthmatic attacks can base their therapeutic decisions on numerous studies directed specifically to the care of such patients in the emergency department.1 2 3 If hospitalization is required, there is also an ...

795-800

DURING the past 15 years, echocardiography has become widely accepted as the method of choice for the noninvasive assessment of valvular vegetations in patients with infective endocarditis.1 2 3 4 Reports, however, on the echocardiographic detection of ...

800-808
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ACUTE lymphoblastic leukemia (ALL) is a clonal expansion of cells committed to differentiation as either B or T lymphocytes. These cells retain the differentiation characteristics of the corresponding normal lymphoid precursors.1 The development of ...

808-815

The anthracyclines doxorubicin and daunorubicin are effective antileukemic agents used widely in chemotherapeutic regimens in children for the past 20 years.1 , 2 Dose-related cardiotoxicity is commonly recognized,3 4 5 6 7 8 9 but the late effects on the ...

Review Articles
815-821

Disasters are tragedies that overwhelm our communities, destroy our property, and harm our populations. The United Nations General Assembly, recognizing the magnitude of the problem, has declared the 1990s the International Decade of Natural Disaster ...

822-831

DIAGNOSTIC, medical, and surgical advances over the past decade have greatly changed the management of secretory pituitary tumors. Improvements in magnetic resonance imaging have advanced the noninvasive visualization of smaller pituitary adenomas. ...

Case Records of the Massachusetts General Hospital
831-840

Presentation of Case

A 67-year-old man was admitted to the hospital because of a ventricular septal defect and increasing exertional dyspnea.

There was a history of a heart murmur since childhood. Thirty years before admission the patient received a ...

Editorials
841-843

Over the past 30 years, cardiac ultrasound examinations have been used in an ever-increasing number of clinical applications. Echocardiography currently has important uses in a range of disorders, including valvular, ischemic, myocardial, pericardial, ...

843-845

Doxorubicin (Adriamycin) and the related anthracycline antibiotic daunorubicin play a central part in cancer therapy because of their efficacy in the treatment of hematologic cancers (both acute leukemias and lymphomas), as well as carcinomas of the ...

Correspondence
845-847
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To the Editor: You took a position (understandably) against the publication of the results of the Nazi experiments, stating that these studies "are such a gross violation of human standards that they are not to be trusted at all."1 What is less ...

847-848
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To the Editor: In his excellent contribution about the clinical features of the acquired immunodeficiency syndrome (AIDS) in Uganda (Aug. 9 issue),1 Dr. Goodgame reported a dramatic increase in the incidence of cerebral malaria at Mulago Hospital in the ...

849-850

To the Editor: Lantos and Frader1 offer a well-written and thoughtful paper on extracorporeal membrane oxygenation (ECMO) in neonates with respiratory difficulties. However, in proposing that a technology such as this (which has the potential for serious ...

850

To the Editor: Over the past three decades many explanations have been advanced for bone loss in adults (i.e., involutional osteoporosis). Some of these explanations relate to diet, including insufficient intake of protein, calcium, phosphorus, magnesium,...

850-851

To the Editor: In patients with lithium-induced nephrogenic diabetes insipidus, indomethacin has been reported to decrease urinary output and raise urinary osmolality.1 Indomethacin is an inhibitor of prostaglandin synthesis in the kidney.2 In the renal ...

851-852

To the Editor: Agocs and coworkers (Oct. 18 issue)1 report that mercury vapor released from latex paint can produce a median concentration of 10 nmol of mercury per cubic meter of room air, or 10 nmol per 1000 liters (2 μg per 1000 liters). If one ...

852
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To the Editor: Several years ago the break-dancing craze sparked concern over the risk of cervical spinal injuries after the report of several cases in young dancers.* The latest dance to sweep North America, the lambada, has also proved to be not ...

852
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You arrive so coldly still Moments ago swelled your faceless body with vigor and pulse Now I ask breathe please breathe

Unimpeded the silence returns your icy figure home with such ease

Little one so freshly poised the life force within forming ...

Book Reviews
852-853

Johnston and Hopkins predict a catastrophe of awesome proportions caused by the spread of the acquired immunodeficiency syndrome (AIDS). They forecast that by the year 2002, at worst there will have been 14.5 million cases of infection with human ...

853

This is a useful and interesting book. It will be particularly welcome to anyone who wants to know how the organizational and institutional structure of public health in the United States came into being. The Sanitarians is a good title, since the book ...

853-854

How scientific discoveries come about and what creates the environment in which they are made are perennial problems faced by historians of science. This book by Alexander Kohn, the editor of The Journal of Irreproducible Results, is a sober reflection on ...

854

The problem of the increasing size of the world's population is a cause of at least a subliminal unease in the minds of most Americans. The chief aim of this book is not only to bring the entire situation more fully into our conscious awareness but also ...

854

In this book the authors discuss various approaches that have been used in the public and private sectors to control health care costs, with primary emphasis on the period from 1970 to the mid1980s. The thrust of the book is on hospital cost containment, ...

854-855

When I received a book from across the Atlantic on a subject about which I considered myself somewhat expert, by an author about whom I had heard nothing, a book that soon revealed itself to be a compendium of vast, jumbled, and disarrayed knowledge (most ...

855-856

Reading more medical fiction and nonfiction over the past 25 years than I care to acknowledge has jaded my perspective on new works, but Perri Klass' new novel, Other Women's Children, held my attention to the end. Curiously, the experience of reading it ...

Books Received
856

Biomedical Science

Advances in Neural Regeneration Research. (Neurology and Neurobiology. Vol. 60.) Edited by Frank J. Seil. 422 pp., illustrated. New York, Wiley-Liss, 1990. $85.

AIDS and the New Viruses. Edited by A.G. Dalgleish and R.A. Weiss. 219 pp., ...

Notices
857

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

MEDICAL COLLEGE OF GEORGIA

The following courses will be offered in Augusta, ...

Special Reports
857-859
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Until last August, the military medical departments were busy providing peacetime health care, training personnel for wartime roles, and modernizing medical equipment for field use. This changed dramatically when the United States began to deploy a ...

859-864
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Whenever Americans spend time in foreign lands, they may become infected with pathogens alien to the United States and bring these pathogens back with them. Mass deployments of the U.S. Armed Forces abroad amplify this risk since military personnel are ...