THERE is considerable experimental evidence to indicate that tumor growth is dependent on angiogenesis.¹ Thus, after a new tumor has attained a small size of a few millimeters in diameter (about 10⁶ cells), further expansion of the tumor-cell population ...

HUMAN exposure to polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) is a matter of great concern in many parts of the world. Some of these compounds are the most toxic manufactured chemicals known, at least in some ...

TWO major limitations of coronary angioplasty are acute occlusion and late re-Stenosis. The concept of implanting an endoluminal stent in the coronary arteries after balloon dilation to circumvent these problems was first suggested in 1964.¹ This ...

ARYLSULFATASE A is a lysosomal enzyme inL volved in the degradation of cerebroside sulfate, a polar glycolipid that is found mainly as a component of the myelin sheaths of the nervous system. Deficiency of arylsulfatase A results in metachromatic ...

TYPE IV glycogen storage disease is a rare autosomal recessive disorder (also called Andersen's disease¹ or amylopectinosis) in which the activity of branching enzyme alpha-1, 4-glucan: alpha-1, 4-glucan 6-glucosyltransferase is deficient in the liver as ...

EVER since automobiles were introduced to the public in the late 1800s, some medical conditions have been recognized as posing risks of driving accidents. Conditions such as epilepsy and diabetes mellitus that can impair consciousness or cause loss of ...

ACQUIRED abnormalities of platelet function are very common. Platelet function, as assessed by in vitro studies or the bleeding-time test, is affected by a vast number of drugs, common foods, vitamins, and spices; by systemic conditions such as chronic ...

Presentation of Case

A 45-year-old man was admitted to the hospital because of cervical pain and an epidural mass.

There was a history of pulmonary tuberculosis 11 years earlier that was treated with isoniazid, pyridoxine, and rifampin for 18 months. Two ...

MORE than three years ago, a report was published in the Journal on the use of intravascular stents to prevent occlusion and re-Stenosis after transluminal angioplasty.¹ Indications that the principal conclusion of the article was premature arose three ...

CONCERN about the effects of health on the ability to drive safely goes back to the early years of the century, with warnings in 1904 about the hazards of alcohol and legislation in 1939 to regulate driving by persons with epilepsy. The general impression ...

INHERITED abnormalities of glycogen metabolism were recognized very early, because pathologists could identify gross accumulations of glycogen in tissues during postmortem examinations. The specific patterns of tissue involvement permitted recognition of ...

DEATHS

BLUTE — James Francis Blute, Jr., M.D., of Framingham, died on September 18 at the age of 72.

Dr. Blute received his degree from Harvard Medical School in 1942. He was a member of the American Medical Association, the American College of Cardiology,...

To the Editor: In the June 21 issue, Gerberding et al. report on 117 cases of exposure to blood in the operating room during 1307 consecutive surgical procedures and use these data to determine the case exposure rate and exposure rate.* The investigators ...

To the Editor: The report by Ludwig et al. (June 14 issue)¹ that treatment with recombinant human erythropoietin corrected anemia in 11 of 13 patients with multiple myeloma is of great interest, but it may frighten hospital pharmacy committees that ...

To the Editor: Between 1976 and 1983, 40 women with hyperprolactinemia who were treated with bromocriptine in our clinic became pregnant. They had had amenorrhea-galactorrhea for an average of four years. Their pretreatment serum prolactin concentrations ...

To the Editor: The data presented by Pekkanen et al. (June 14 issue)¹ suggest that the levels of total, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) cholesterol predict subsequent cardiovascular mortality among middle-aged men, ...

To the Editor: The cloning of the cystic fibrosis gene has been accompanied by predictions of mass screening of populations for this and other common genetic diseases. Although the recent statement of the Workshop on Population Screening for the Cystic ...

To the Editor: The medical treatment of patients receiving long-term corticosteroid therapy presents several risks, including suppression of the adrenal axis and the possibility of infection with unusual organisms. A physician aware of a patient's risk ...

To the Editor: Drs. Rosario and Fernandes recently reported a case of Erb's palsy, or upper brachial plexus palsy, caused by wearing a heavy backpack (May 31 issue).¹ Their report is not unique. Other names have been given to this syndrome. "Pallbearer's ...

To the Editor: Epstein et al. (April 19 issue)* provide strong evidence that the care of patients of low socioeconomic status costs more than the care of other patients. In this age of limited medical resources, research of this type is essential to ...

To the Editor: Patients seem to be continually trying to stretch the bounds of what they perceive as their physician's obligation. At least two calls to my office per week are requests for a "doctor's letter" for use in attaining some nonmedical goal. ...

Here is the second edition of this already very successful textbook. It is beautifully illustrated and produced, with many diagrams, photographs, and tables. The judicious use of color greatly facilitates comprehension of the material. The book is ...

Stanbury, Fredrickson, and Wyngaarden created a comprehensive atlas of the known metabolic world in 1960, with the first edition of this book. There were 46 chapters, each devoted to a group of related problems or a specific biochemical disorder (e.g., ...

This is a wonderful source book on the basic, epidemiologic, and clinical aspects of animal and human virology for all students of the subject. This book will remain the prime resource in this field. Medical students, medical residents, microbiologists, ...

With an increasing number of physicians outside the workplace called on to provide occupational medicine services for which they have generally had little formal training, accessible authoritative sources of practical information are desperately needed. ...

A good physician is a scientist, artist, and philosopher. A wise clinician recognizes the many facets of medicine; an ethical physician acknowledges the multidimensional boundaries of his or her particular practice. Therefore, clinical ethics is often ...

Natelson joins a well-established tradition when he offers advice to "tomorrow's doctors" in this readable and provocative book. Perhaps his greatest contributions are his enthusiasm for medicine and his optimistic vision of the future of medical ...

Physicians, with their traditional medical practices, have long been afforded a special, exclusive status in American society, as reflected, for example, in state licensure statutes that restrict the performance of certain diagnostic and therapeutic ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

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UNIVERSITY OF ILLINOIS AT CHICAGO

The following courses will be offered in ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 6, 1988, issue of the British Medical Journal and the February 1988 issue of the Annals of ...