THE acquired immunodeficiency syndrome (AIDS) develops years after infection with human immunodeficiency virus type 1 (HIV-1).^{1 , 2} Because of this long latency, the epidemiology of newly diagnosed AIDS largely reflects the pattern of HIV–1 infections ...

LYME disease, which is caused by the tick-borne spirochete Borrelia burgdorferi, often begins with a characteristic skin lesion, erythema migrans, and is commonly followed by neurologic, cardiac, or joint abnormalities of variable duration.¹ The ...

THE elevation of plasma low-density lipoprotein (LDL) cholesterol levels is recognized as a primary risk factor for the development of atherosclerosis and coronary heart disease.^{1 , 2} Therefore, much interest has been focused on the regulation of plasma ...

IMMUNE thrombocytopenic purpura occurs frequently in young women and may first be diagnosed during the childbearing years or pregnancy. In some women with immune thrombocytopenic purpura, pregnancy and childbirth are complicated by severe neonatal ...

SINCE the time of Hippocrates, cachexia has been recognized as a prominent feature of patients with end-stage heart failure.^{1 , 2} Although numerous theories about its pathogenesis have been proposed,^{2 , 3} the cause of the profound weight loss and anorexia ...

MONOCLONAL antibodies are potentially useful therapeutic agents in a variety of immunologically mediated diseases, offering the theoretical advantage of selective attack on cells implicated in the immunopathogenesis of these disorders. Antibodies to ...

VIRAL infections of the central nervous system (CNS) have attracted the attention of historians and physicians for millennia.^{1 , 2} With the exception of herpes simplex encephalitis,^{3 , 4} the specific causes of CNS syndromes of viral origin have been ...

Presentation of Case

A 47-year-old man was admitted to the hospital because of a rash and fever.

He was well until four days earlier, when a pruritic rash developed over the upper arms. The patient recalled exposure to poison ivy one week earlier and ...

It has been known for many years that the platelet-reactive autoantibodies responsible for platelet destruction in chronic idiopathic (autoimmune) thrombocytopenic purpura (ITP) can cross the placenta and cause thrombocytopenia in the fetus.¹ The ...

Arnold Relman, editor-in-chief of the Journal, has dubbed it "the third revolution in medical care."¹ That description of what I call the outcomes movement may be hyperbole, but clearly we have entered an era of unprecedented growth in activity directed ...

In 1987 New York became the first state to enact legislation governing the withholding of cardiopulmonary resuscitation (CPR). Although no other states have actively legislated the conditions under which CPR will not be performed, other jurisdictions are ...

DEATHS

Bonner — Charles Douglass Bonner, M.D., of Newton Centre, died on May 10 at the age of 73.

Dr. Bonner received his degree from Boston University School of Medicine in 1944. He was a member of the American Medical Association, the American ...

To the Editor: I have two comments concerning the interesting findings of Ginsberg et al. (March 1 issue).¹

First, the authors did not report the caloric intakes or exercise levels of the men during the study. Although body weights were reported not to ...

To the Editor: Recent reports have documented the occurrence of in vitro resistance of strains of the human immunodeficiency virus (HIV) to zidovudine.^{1 , 2} To date, although there has been suspicion of clinical failure during zidovudine therapy,³ there ...

To the Editor: An association between high-grade non-Hodgkin's lymphoma and HIV infection has been demonstrated in several groups at risk for AIDS.^{1 2 3} However, whether Hodgkin's disease is associated with HIV infection is controversial. Hodgkin's ...

To the Editor: Common variable immunodeficiency is a heterogeneous group of familial or sporadic diseases characterized by recurrent infections and B-cell dysfunction resulting in low levels of serum immunoglobulins.¹ It may be a result of an accessory-...

To the Editor: Using flow cytometry, Epstein and colleagues (March 8 issue)* found that myeloma cells expressed not only features characteristic of myeloma cells but also markers expressed on preB cells, megakaryocytes, myelomonocytes, and erythroid ...

To the Editor: In an otherwise praiseworthy update of occupational medicine by Cullen et al. (March 8 issue),¹ some disturbing literature citations becloud the section on carcinogenesis, particularly Table 3. The two articles cited in reference to ...

To the Editor: As presented in a summary by Lohr and Schroeder (March 8 issue),¹ the committee of the Institute of Medicine of the National Academy of Sciences confirmed "that interventions attempted by the PROs [peer-review organizations] to remedy ...

To the Editor: The Special Article on new pathways in general medical education (Jan. 25 issue)¹ is thought-provoking and interesting. Dr. Tosteson discusses the increasing rate of change in knowledge and technology, which places increasing burdens on ...

Emergency medicine, anesthesia, and critical care form a continuum through which care is provided to the most acutely ill patients. These two books address different aspects of that care, with reasonable success.

The book edited by Vanstrum is the more ...

This multiauthored comprehensive textbook was designed to review the care of surgical patients. It is sponsored by the committee on preoperative and postoperative care of the American College of Surgeons. The authors are a veritable who's who of ...

Here is an important contribution to cardiothoracic surgery that should become a classic. Although the concept of a surgical atlas is not unique, this book is uniquely successful in its execution. Two surgeons experienced in adult and pediatric ...

Endovascular surgery is a new, rapidly evolving, and important mixture of interventional radiology, vascular surgery, and cardiology. In bringing together contributions from these overlapping specialties in a single volume, the editors have provided us ...

Mild and moderate head injury account for most of the head trauma encountered around the world, and yet the amount of comprehensive information available concerning this very common problem is relatively sparse. This book addresses two major features of ...

Here is a treasure to behold. Dr. Hinman's book is a profound, timely work, especially useful for urologists, urology residents, students, or anyone who operates on the genitourinary system. The illustrations are uniform, clear, and effective. The ...

The authors indicate that the purpose of the book is to "describe in a clear and concise fashion the various conditions affecting the lumbar spine, readable by all professionals: young orthopaedists and neurosurgeons, family practitioners, therapists, and ...

COMPREHENSIVE FINE NEEDLE BIOPSY

The 10th annual course will be offered in Hamilton, Bermuda, Aug. 5–11.

Contact Univ. of California, San Francisco, Extended Programs in Medical Educ., Rm. C-124, San Francisco, CA 94143; or call (415) 476–4251.

...

Screening Immigrants and International Travelers for the Human Immunodeficiency Virus (June 14, 1990; 322:1743–6). On page 1744, right column, line 35, and on page 1745, left column, line 9, Immunization and Naturalization Service should have read ...