IN many patients with coronary artery disease, impaired left ventricular systolic function at rest is caused by regionally ischemic or "hibernating" myocardium rather than irreversibly damaged myocardium.^{1 , 2} In such patients, left ventricular function ...

THE formation of a thrombus in a stenosed coronary artery has a causative role in the pathogenesis of acute myocardial infarction,^{1 , 2} and patients who recover from the acute phase are at risk for subsequent infarction.³ Oral anticoagulants have ...

THE Marfan syndrome is an inherited disorder of connective tissue characterized by pleiotropic manifestations in many organs, including the eyes, heart, aorta, skeleton, skin, and lung. Life expectancy is reduced by one third, on average, because of ...

MEASLES remains a devastating disease, for which specific therapy is lacking. Hopes for its control and eventual eradication rest on immunization, but measles kills about 2 million children each year¹ and cripples an untold number through blindness² and ...

HEMOGLOBIN is a tetramer consisting of two pairs of globin chains, each of which is associated with a heme group. In adults, the predominant hemoglobin — hemoglobin A — is composed of two α-globin and two β-globin chains (α₂β₂); the principal fetal ...

Pericardial Disease

Echocardiography is the procedure of choice for the diagnosis of pericardial effusion. The method is extremely sensitive in the detection of even small effusions, and the amount of fluid can be estimated by considering the size of the ...

A HUMAN being possesses on the order of 1 trillion (10¹²) B cells, capable of making more than 10 million different antibodies. Tapping this vast resource for clinical purposes is an important but technically challenging endeavor. The production of ...

Presentation of Case

A 43-year-old woman was admitted to the hospital because of low-back pain and a presacral mass.

The patient was well until seven months earlier, when increasing pain developed in the left buttock; the pain was aggravated during her ...

Myocardial perfusion imaging with thallium-201 has been used to improve detection and risk stratification in ischemic heart disease. Thallium-201 is administered intravenously as a monovalent cation during peak exercise, during the infusion of the ...

At a specialty conference, a postdoctoral fellow describing a new study being conducted at a neighboring institution showed a recruiting letter from the investigator, which outlined the study and noted that a $350 finder's fee would be paid to resident ...

To the Editor: Although the clinical trial of the use of azathioprine in patients with Behçet's syndrome was well conducted by Yazici et al. (Feb. 1 issue),¹ the variables that they used to assess improvement in eye disease and the criteria for ...

To the Editor: Although the study by Moertel et al. (Feb. 8 issue)¹ was well conducted and analyzed, the lack of a group given fluorouracil alone greatly mitigates the credibility of the concluding advice that this two-drug regimen be offered to the ...

To the Editor: Patients with human immunodeficiency virus (HIV) infection are predisposed to infection with salmonella species.¹ Although the majority of infections are due to Salmonella enteritidis serotype typhimurium, two recent reports describe ...

To the Editor: In 1979 an eight-year-old boy (Fig. 1, Subject III-1) was referred because of unexplained fever, skin rash, and proximal-muscle weakness and pain. On the basis of these symptoms, an increased serum creatine kinase level (8600 U per liter), ...

To the Editor: Data derived from the 1988 National Hospital Discharge Survey conducted by the National Center for Health Statistics lead us to believe that the rate of cesarean section in the United States has stabilized. The 1988 rate was 24.7 cesarean ...

To the Editor: Although the data from the National Center for Health Statistics document a slower rate of increase in the use of cesarean section than has been observed in the past (see previous letter, by Taffel et al.), the use of cesarean section ...

To the Editor: Dr. Jenike suggested (Feb. 22 issue)* that an ethical line be drawn between speakers at medical symposiums and members of the audience in determining which physicians could appropriately have their expenses, "including travel with spouse, ...

To the Editor: The 1990 version of the "doctornurse game" as described by Stein et al. (Feb. 22 issue)* indicates a lack of awareness of changes in the health care system, as well as in professional nursing. No nurse would expect a doctor to extend a ...

This pleasant and easy-to-read book is not truly a history, but rather a set of reminiscences and views of Japanese culture that "have tumbled out of the closet of the mind like old garments whose warmth had been forgotten." It was written by a geneticist ...

Historians often overlook the impact of illness and health care on the conquest and maintenance of Europe's colonies. Studying that impact provides rich lessons in history and allows important insights into the ways cultures interact, the ways societies ...

The need for sectional atlases has arisen from an increasing reliance on techniques such as CT, magnetic resonance imaging, and ultrasonography. As anatomical depiction by these devices has improved, so has the sophistication and detail of the atlases. ...

This is a timely and thoughtful book. The authors have expertise in this field and have concisely summarized their knowledge. The first two chapters concern the basic principles of cerebrospinal fluid flow and the principles of magnetic resonance imaging ...

Since the publication of Vesalius' Fabrica in 1543, anatomical atlases have had an evocative fascination for all members of the medical profession. It has been alleged that physicians are all little Platonists or little Aristotelians. Both philosophers ...

This is an anatomical atlas with black-and-white photographs of axial and sagittal 1-cm-thick sections of the entire body, in both male and female cadavers. Anatomically correlated magnetic resonance (MR) images are provided in both planes for each level ...

The publication of this third edition of the Pernkopf Anatomy testifies to the success that this classic atlas has met with among anatomists throughout the world. The book has many new illustrations, all of which have been executed to a very high ...

Biomedical Science

Advanced Immunochemistry. Second edition. By Eugene D. Day. 693 pp., illustrated. New York, Wiley-Liss, 1990. $120.

Basic Aspects. (GnRH Analogues in Cancer and Human Reproduction. Vol. 1.) Edited by B.H. Vickery and B. Lunenfeld. 161 ...

AWARDS FOR RESEARCH OF DEPRESSION IN YOUNG ADULTHOOD

Applications are being accepted for two annual awards for research regarding origin, course, and treatment of depression in young adulthood. Deadline for receipt is Sept. 10.

Contact Dr. Stuart C. ...

The Effect of Protein Restriction on the Progression of Renal Insufficiency (December 28, 1989; 321:1773–7). On page 1774, in Table 2, in the two columns headed "18 mo" the mean ±SEM values for ⁵¹Cr-EDTA clearance (ml/sec) should be 0.10±0.01, not 0.10±...

Opinion surveys conducted this year indicate that nearly three of four Americans (72 to 73 percent) favor some form of a national health care program.^{1 , 2} In fact, as Figure 1 shows, support for one type of proposal — a plan financed entirely by ...