IN recent years Candida albicans, a yeast that is part of the normal human intestinal flora, has been thought by some to cause a disorder variously known as the candidiasis hypersensitivity syndrome, chronic candidiasis, candida-related complex, and the "...

POST-TRANSPLANTATION lymphoproliferative disorder is a well-recognized, frequently fatal complication of immunosuppression.^{1 , 2} The term encompasses a spectrum of abnormal proliferations of B lymphocytes that occur after organ transplantation. Such ...

THE term "pemphigus" refers to mucocutaneous diseases that are characterized by intraepithelial blisters, caused by a loss of normal cell-cell adhesion (acantholysis¹), and are associated with autoantibodies against cell-surface proteins of stratified ...

EXERCISE is a common stimulus of bronchoconstriction in subjects with asthma.¹ Exercise-induced bronchoconstriction may be caused by alterations in the temperature of the airways, in the osmolality of the epithelial-lining fluid resulting from the ...

ASTHMA is a disease characterized by episodic bronchoconstriction, hypersecretion of mucus, and inflammation of the airways. Evidence suggests that substances derived from the action of the enzyme 5-lipoxygenase on arachidonic acid may have a role in ...

THE investigation of leukotrienes as mediators of immediate-hypersensitivity reactions began with their isolation in 1940 as a "slow-reacting substance" associated with antigen challenge of sensitized lung preparations¹ and was greatly stimulated by the ...

H₂ Blockers in Peptic Ulcer Disease

Duodenal Ulcer

All four H₂ blockers, when used in the doses shown in Table 1, are capable of healing duodenal ulcer to approximately the same degree.^{203 204 205 206 207 208 209 210} The average rates of healing with H₂ ...

Presentation of Case

A 57-year-old man with hepatic cirrhosis and ascites was admitted to the hospital because of the recent onset of proteinuria and microhematuria.

The patient was a construction laborer who was disabled by degenerative joint disease of ...

Few illnesses have sparked as much hostility between the medical community and a segment of the lay public as the chronic candidiasis syndrome. Those who argue for the existence of this complex of symptoms (also known as polysystemic candidiasis and the ...

Since 1968, when an increased incidence of lymphomas was noted in renal-transplant recipients,¹ evidence has accumulated that organ transplantation, and the immunosuppressive therapy associated with it, are complicated by an increased incidence of certain ...

The term "slow-reacting substance of anaphylaxis" was coined originally to describe tissue effluent released during an antigen–antibody reaction that triggered a prolonged contraction of smooth muscle.^{1 , 2} Initial descriptions of this biologic activity ...

To the Editor: Singer and Siegler (June 28 issue)* define euthanasia as a "deliberate action by a physician to terminate the life of a patient." Like the generals who prepare for the last war and lose the next, they use yesterday's frame of reference to ...

To the Editor: The article by Panza et al. (July 5 issue)¹ reported an impairment of endothelium-dependent vascular relaxation induced by acetylcholine in patients with essential hypertension. In the Discussion section the authors argued against the ...

To the Editor: The finding of Seed and colleagues (May 24 issue)¹ that an elevated level of lipoprotein(a) is a strong, independent risk factor for coronary heart disease in patients with familial hypercholesterolemia is provocative. However, the ...

To the Editor: Regarding the study of Hussey and Klein (July 19 issue),* I would question the ethics of performing such a study when, as the authors acknowledge, there was already good reason to think that giving vitamin A to the patients would decrease ...

To the Editor: We describe a patient with human immunodeficiency virus (HIV)—associated nephropathy^{1 2 3 4 5} who had transient clinical improvement after the initiation of zidovudine therapy.

A 57-year-old black man was found to have the nephrotic ...

To the Editor: Selegiline (Eldepryl), a selective monoamine oxidase type B inhibitor, is a new medication recently approved as adjunctive therapy for Parkinson's disease. Trifluoperazine (Stelazine) is a neuroleptic agent that blocks dopamine receptors ...

To the Editor: Recently, we had a case that dramatizes the hazard of an old remedy in a new era.

A five-year-old girl presented to the emergency room with partial-thickness burns over 40 percent of her body. Her parents stated that the child had acquired ...

To the Editor: During the last week of January 1990, an unusually heavy snowfall in the Selkirk Mountains of eastern British Columbia produced skiing conditions characterized by a bottomless powder base with up to 7 ft of untracked light-powder surface. ...

Red wagon rider,

pale, puffy passenger

parked in a white-coat forest

harvested, then regrown

by sliding doors opening,

your pain-dulled, drug-blurred eyes

stare uncomprehending

as your pretty minder,

yoked between wagon handle

and I.V. pole,

whispers ...

In preparing my review of the fifth edition of this book, I reread Williams' review of the first edition, published in 1973. In that review (N Engl J Med 1974; 290:1266–7), Kaplan was praised for undertaking a book of such scope. In the subsequent 17 ...

These two books teach interpretation of the electrocardiogram. Although both cover the basics and follow a pattern-reading approach (rather than a vector interpretation), they are quite different in scope, style, and audience. One is an introductory ...

In its second edition, this is a comprehensive book for understanding diving accidents and illnesses occasioned by the marine environment.

In the past few decades, the discipline of diving medicine has evolved from contemplating the effects of hyperbaric ...

This third edition is substantially updated from the second edition, published in 1984. As the editors note in their preface, the previous edition described a relatively small field of antiviral agents available to the clinician, including idoxuridine, ...

The rapid progress made in pharmacology over the past two decades has given us an enormous wealth of knowledge, a better understanding of drug action, and a plethora of novel drugs. It has ushered in the most exciting era in pharmacotherapy. This presents ...

This book is the second edition of a work originally published in 1986. The list of contributors has increased from 29 to 36, and the number of pages has increased proportionally. A chapter on starvation has been deleted from the current edition, and a ...

MEDICLINIC INTERNATIONAL CONVENTIONS

The following will be held: "General Medicine" (Lech, Austria, Jan. 13–19, and St. Moritz, Switzerland, Jan. 20–26) and "Medico Legal Conference: Attorneys, Physicians, Dentists and Pharmacists" (Grindelwald, ...