ISOLATED atrial septal defect is the third most common form of congenital heart disorder presenting after childhood (bicuspid aortic valve and mitral-valve prolapse are first and second).^{1 2 3} Even if unrepaired, this defect is often compatible with ...

NEUROLOGIC abnormalities occur with increased frequency in children who have had bacterial meningitis.^{1 2 3 4 5 6 7 8 9 10 11 12} Although this association of meningitis and neurologic abnormalities is well established, several important questions remain ...

THE annual incidence of Haemophilus influenzae type b meningitis among children under five years of age ranges from 30 to 70 cases per 100,000 in the population.^{1 , 2} Mortality and morbidity from this disease are thought to be due in large part to brain ...

nutritional factors are strongly suspected of being important in causing colon cancer. In Western countries the rates of the disease are up to 10 times those of many Far Eastern and developing nations.¹ Rapid increases in rates of colon cancer among ...

THE clinical manifestations of primary ciliary dyskinesia (PCD) — recurrent sinopulmonary infection and male sterility — have been attributed to defects in the ultrastructure of the central core (axoneme) of cilia and sperm tails. In the respiratory tract,...

CYSTIC fibrosis is the most common lethal inherited disorder in the white population. It is manifested by viscous secretions in the lungs and pancreas and abnormal electrolyte composition of sweat.¹ Epithelial cells from patients with cystic fibrosis have ...

THIS article reviews the clinical pharmacology of histamine₂-receptor antagonist drugs (H₂ blockers) and their usefulness in the treatment and prevention of acid-peptic disorders — namely, peptic ulcer disease, Zollinger—Ellison syndrome, gastroesophageal ...

Presentation of Case

A 65-year-old man was admitted to the hospital because of an obstructing nasopharyngeal mass and lymphadenopathy.

The patient was well until one month earlier, when a sore throat and dysphagia developed, and he became unable to ...

Atrial septal defects account for 7 to 10 percent of all congenital cardiac malformations and for almost one third of cases of congenital heart disease among adults.¹ In 1953 it became the first intracardiac defect to be corrected successfully with ...

Cilia at the epithelial surface of conducting airways protect the lungs through their pivotal role in the clearance of mucus and potentially injurious inhaled particles. Clearance requires ciliary movement, a function that depends in turn on specialized ...

A young Maryland mother discovered that she had relapsed only six months after receiving adjuvant chemotherapy for breast cancer. Assessing her poor prognosis, the woman's oncologist recommended high-dose chemotherapy with autologous bone marrow ...

To the Editor: The Framingham group is in a unique position to explain the decline in mortality from ischemic heart disease that has occurred since about 1968.¹ The study by Sytkowski et al. (June 7 issue)² shows that approximately 96 percent of the ...

To the Editor: Data from the Framingham Heart Study presented by Levy et al. (May 31 issue)¹ suggest that in subjects free of cardiovascular disease, increased left ventricular mass, detected by echocardiography, is an independent predictor of morbidity ...

To the Editor: Trip and colleagues (May 31 issue)* are to be complimented on their important findings regarding the prognostic value of spontaneous platelet aggregation (SPA). We would like, however, to note a number of reservations.

Although the study ...

To the Editor: I offer the following comments to add to the discussion of the Case Record of a 6 1/2-year-old black girl presenting with secondary sexual development and an episode of vaginal bleeding (Nov. 23, 1989, issue).¹ Certainly, most clinicians ...

To the Editor: The incidence and natural history of elevated serum amylase levels in patients with symptomatic human immunodeficiency virus (HIV) infections are unknown, despite the importance of amylase determinations in patients receiving ...

To the Editor: Despite evidence demonstrating the effectiveness of donor-screening procedures for HIV type 1 (HIV-1),^{1 , 2} there remains considerable concern among members of the general public about the safety of the blood supply. Both indirect and ...

To the Editor: We report the production of granulocyte colony-stimulating factor (G-CSF) in a patient with bladder cancer, which was confirmed by immunofluorescence staining of tumor tissue. A 48-year-old man died of bladder cancer (transitional-cell ...

To the Editor: Although Dr. Lind (July 19 issue)* argues cogently against the use of finder's fees, I believe there is room for them in recruiting patients without a violation of medical ethics.

First, we accept that it is not wrong for investigators to ...

To the Editor: Dr. Relman has identified conflicts of interest that arise when physicians refer patients to facilities that they own or when they dispense drugs.^{1 2 3} He has explained that conflicts of interest arising from referrals are more nefarious ...

Ten years ago textbooks required only one sentence to disclaim any reliable knowledge of the cause, prevention, and nonsurgical treatment of large-vessel aneurysms. This book is evidence of the explosion of both knowledge and theory since that time. The ...

This atlas, recently translated from the German, deals exclusively with surgery of the esophagus, stomach, and duodenum. This subject is discussed in depth in 380 pages, with 1139 drawings.

This work is unusual for several reasons. The contributors ...

I thoroughly enjoyed reading this textbook, which reviews an important and timely urologic topic — the clinical management of renal-cell carcinoma. Part I deals with epidemiology and diagnosis, part II with surgical aspects, and part III with metastatic ...

The first of these books, by Boyd, provides an elementary overview of selected aspects of gynecology. It is not intended to be a comprehensive textbook of gynecologic surgery, but rather a personal and practical compendium of common gynecologic conditions ...

This attractively bound, conveniently sized book provides easy reading and quick access to information. The drawings, radiographs, and photographs are meticulously reproduced. The editors have organized the book into four sections: classification and ...

Bonica has directed this second edition of his classic work to both students looking for a textbook and clinicians who need a reference source. His aim is accurate, and his work is encyclopedic in nature, extensive in scope, and intensive in depth.

For ...

Medicine

The Duodenum: Selected topics. Edited by G. Bertaccini, R. Cheli, G. Dobrilla, A. Gad, and A. Giacosa. 303 pp., illustrated. New York, Raven Press, 1988. $76.50.

Haematological Aspects of Systemic Disease. Edited by I.W. Delamore and J.A. Liu ...

AMERICAN BOARD OF INTERNAL MEDICINE EXAMINATIONS

The "1991 Certifying Examination in Internal Medicine" will be held Sept. 24 and 25; registration will continue until Feb. 1. The "1991 Subspecialty Examinations in Cardiovascular Disease, Critical Care ...

A Controlled Study of Early Neurologic Abnormalities in Men with Asymptomatic Human Immunodeficiency Virus Infection (September 27, 1990; 323:864–70). On page 864, the right-hand column of the abstract, in the third line, the word "poor" should have been ...

Book review of Drugs and the Athlete (November 1, 1990; 323:1286–7). The address given for the author of the review, Douglas B. McKeag, should have been Michigan State University, East Lansing, MI 48824. We regret the error.