THROMBOLYTIC therapy administered early after the onset of acute myocardial infarction has been shown to decrease infarct size, improve ventricular function, and reduce early mortality.^{1 2 3} Nevertheless, several issues remain unresolved, including the ...

LYME disease, which is caused by the tick-borne spirochete Borrelia burgdorferi, is associated with a wide variety of neurologic abnormalities.^{1 2 3 4 5 6 7} Early in the illness, many patients have episodes of headache and mild meningism.⁸ Within several ...

PNEUMOCYSTIS CARINII pneumonia is the most JL common opportunistic infection associated with the acquired immunodeficiency syndrome (AIDS). In approximately 60 to 65 percent of patients with AIDS, it is the AIDS-defining diagnosis; another 20 percent of ...

PNEUMOCYSTIS CARINII pneumonia remains a common cause of serious morbidity and mortality in patients with the acquired immunodeficiency syndrome (AIDS).^{1 2 3 4 5 6 7 8} The extensive lung injury found in patients with respiratory failure due to ...

THERE is growing evidence of the existence of a family of recessive genes that can promote tumor growth when both alleles are inactivated.^{1 2 3 4} The prototype of such tumor-suppressor genes is the retinoblastoma-susceptibility (Rb) gene, which is located ...

OVER the past 18 years the Canadian health care system has been more successful in containing costs than its American counterpart. With provincial governments as the sole purchasers of almost all essential medical and hospital services, administrative ...

ONE of every 11 Americans who live to be 80 years old will have had at least one seizure. About 3 percent of the population has recurrent, unprovoked seizures (epilepsy).¹ In the United States, the estimated prevalence of active epilepsy is 6.42 cases per ...

Presentation of Case

A 51-year-old man was admitted to the hospital because of a history of hemoptysis and epistaxes and cavitary lesions of the left lung.

The patient was well until three months earlier, when a cough developed that was productive of ...

In this issue is a letter from Pintor and colleagues¹ that corrects the conclusions of a paper they published in the Journal nearly two years ago.²

In the earlier paper the authors reported what appeared to be a unique case of Laron dwarfism. The patient ...

Angiographic and pathological studies have established the causative role of coronary-artery thrombosis in acute transmural myocardial infarction.^{1 , 2} The rupture of atheromatous plaque leads to occlusive thrombosis, which produces myocardial ischemia, ...

To the Editor: We previously reported on a child from Sardinia who had the phenotype of Laron-type dwarfism, but had a serum level of insulin-like growth factor I (IGF-I), or somatomedin C, that was within normal limits, as determined by assay of ...

To the Editor: I read with dismay the article by Cubeddu and colleagues (March 22 issue)¹ on the effect of ondansetron on the nausea and vomiting induced by cisplatin chemotherapy. When Gifford and Feinstein² introduced the concept of the double-blind, ...

To the Editor: Endothelin-1 is a newly discovered potent vasoconstrictor peptide produced by vascular endothelial cells.^{1 , 2} To examine whether it may be involved in the pathophysiologic features of ppregnancy-induced hypertension, we measured the ...

To the Editor: Ticlopidine is a novel platelet antiaggregating drug that is more effective than aspirin in preventing strokes in high-risk patients.¹ We wish to report the development of reversible thrombocytopenia in a patient with transient ischemic ...

To the Editor: Hypokalemia is a commonly reported electrolyte disorder^{1 , 2} and an established cause of rhabdomyolysis in humans and laboratory animals.^{3 , 4} However, the prevalence of rhabdomyolysis in patients with hypokalemia is not known.^{1 , 2} To ...

To the Editor: Leber's hereditary optic neuropathy (LHON) is a maternally inherited disease characterized by optic neuropathy and cardiac dysrhythmia. A single mitochondrial DNA mutation, a G-to-A substitution at position 11778 that converts a highly ...

To the Editor: If some underuse has developed in the hospital system of the Department of Veterans Affairs (VA) as a result of tightening the eligibility requirements, should we not raise the poverty line rather than use the slack to provide health care ...

To the Editor: Recent highly publicized judicial decisions and legislative actions have emphasized the importance of medical directives and durable powers of attorney. This is true not only for older, chronically ill people who want to avoid a "$100,000 ...

To the Editor: Gostin et al. (June 14 issue)¹ summarized the many arguments against the testing of travelers for the human immunodeficiency virus (HIV). Although it is frequently misunderstood, there are two major categories of visas to the United States:...

To the Editor: I found it nothing short of unbelievable to read in a recent issue of the Journal that organ transplantation was actually being carried out in HIV-positive recipients.* It was encouraging to read that these patients with hemophilia had a ...

One of America's leading child psychiatrists and the author of more than 40 books, Robert Coles has made it his life's work to understand the strength of character of children. He was awarded the Pulitzer Prize for his Children of Crisis series. Here, in ...

It is always a pleasure to read an article by Professor Ginzberg. To read his 20 papers collected in The Medical Triangle: Physicians, Politicians, and the Public is a rare treat. This is a broad-ranging, insightful, informative review of major policy ...

Increasingly, physicians are seeking help from consultants for the difficult ethical problems that arise in clinical care. Although few would question the value of the service, ethics consultation is an activity still seeking its definition. Here, the ...

This videotape was produced by the American Medical Student Association for the benefit of students in their third and fourth years who are uninformed and anxious about their residency selection, not to mention their choice of careers. The tape is ...

In the majority of medical schools in the United States, the process of medical education has remained substantially unchanged since the Flexner Report. The curricular revisions that have occurred more recently have consisted of the addition of new ...

The title of this book promises complete instructions to help the reader prevent heart disease, or at least understand the principles needed to prevent it. The book is divided into four sections, each of several chapters, that introduce and explore four ...

The author, an internist from West Palm Beach, Florida, became suspicious that many of his patients' symptoms were caused by aspartame. He prepared a questionnaire for his patients that was later given to persons across the country who thought they were ...

Biomedical Science

Adenosine and Adenosine Receptors. Edited by Michael Williams. 516 pp. Clifton, N.J., Humana Press, 1990. $89.50.

Animal Lifestyles and Anatomies: The case of the prosimian primates. By Charles E. Oxnard, Robin H. Crompton, and Susan S. ...

TRANSESOPHAGEAL ECHOCARDIOGRAPHY

The course will be offered in St. Louis, Dec. 4 and 5.

Contact St. Louis Univ. School of Med., CME, 1402 S. Grand Blvd., St. Louis, MO 63104–1083; or call (800) 553–2712.

CALL FOR ABSTRACTS

Abstracts are now being accepted ...

Cyclosporine-Induced Sympathetic Activation and Hypertension after Heart Transplantation (September 13, 1990; 323:693–9). On page 696, in Table 2, for Patients 1 and 2 (who received both cyclosporine and placebo), the placebo data were inadvertently ...

Pneumocystis carinii pneumonia continues to be the most common life-threatening opportunistic infection defining the acquired immunodeficiency syndrome (AIDS) in patients infected with the human immunodeficiency virus (HIV). In the United States an ...