ACCELERATED bone loss occurs with the cessation of menstruation at the time of menopause¹ and in women who have amenorrhea as a result of prolactin-producing pituitary tumors,² anorexia nervosa,³ or intense long-distance running associated with ...

SINCE the association between ulcerative colitis and colorectal cancer was first reported in the 1920s,¹ it has been confirmed in many studies from different countries,^{2 3 4 5 6 7 8 9 10 11 12 13 14 15 16} and the causality of the association is now ...

MOST prospective epidemiologic studies have found an inverse correlation between levels of high-density lipoprotein (HDL) and the incidence of atherosclerotic cardiovascular disease.^{1 , 2} Although HDL levels are known to be decreased by obesity, cigarette ...

EXTRACORPOREAL shock-wave lithotripsy of gallstones was initially performed in vitro^{1 , 2} and in animals.^{3 4 5 6} Then, Sauerbruch and his colleagues in Munich,^{7 , 8} followed by other investigators,^{9 10 11 12 13 14} reported the use of the method to treat ...

LARGE numbers of high-affinity somatostatin binding sites have been found on most pancreatic endocrine tumors and carcinoid tumors.^{1 2 3 4} In the majority of patients with such tumors, long-term therapy with octreotide successfully controls clinical ...

MORE than 50 years ago, von Stössel reported unique autopsy findings in a 43-year-old woman who had died of respiratory failure: her lungs showed diffuse cystic changes and lymphadenopathy on gross examination, and a striking proliferation of smooth ...

IN the United States, it is conservatively estimated that each year 2.5 million people seek medical care for burns. More than 100,000 patients are hospitalized with burns each year, and 12,000 burn victims die of their injuries.¹ The care of burn victims ...

Presentation of Case

A 71-year-old woman was admitted to the hospital with biventricular congestive heart failure and a pericardial effusion.

The patient was well and active until four months earlier, when she began to have epigastric "pressure" on ...

Low bone mass is a major determinant of the osteoporotic fractures that are becoming increasingly common as the population ages. Low bone mass at the time of a fracture may result from either low peak bone mass, which is attained in the third or fourth ...

Almost two decades have passed since Danziger and his coworkers at the Mayo Clinic reported that the primary bile acid chenodeoxycholic acid could dissolve cholesterol gallstones in humans when given orally for six months.¹ After the accumulation of ...

The neuropeptide somatostatin was discovered in Guillemin's laboratory at the Salk Institute 18 years ago.¹ From a relatively humble beginning as a hypothalamic growth hormone inhibitor, it has emerged as a major regulatory peptide with an extraordinary ...

To the Editor: We were disappointed, from a methodologic standpoint, by the article by Schulman et al. on the effects of antihypertensive therapy on left ventricular mass in the elderly (May 10 issue).¹ As indicated in their introduction, one of the ...

To the Editor: Harrison et al. (May 31 issue)¹ describe the successful repair of a fetal diaphragmatic hernia, and they are to be congratulated for developing this skill from use in a variety of animals to clinical application. Having said this, we must ...

To the Editor: The paper by Zielke et al.¹ concluded that there were normal levels of fetal hemoglobin in infants with sudden infant death syndrome (SIDS), as compared with controls. This was at variance with our data² showing increased levels of fetal ...

To the Editor: Although its clinical importance is not always clear, cytomegalovirus is undoubtedly an important opportunistic pathogen in patients with the acquired immunodeficiency syndrome (AIDS).^{1 , 2} This agent may cause retinitis, enteritis, ...

To the Editor: I note an error in the chromosomal location of the human kit locus in the article by Trent et al. (May 24 issue).¹ Figure 1 implies that the human kit locus is found on chromosome 7. I presume this to be a typographic error for the met ...

To the Editor: Movsesian (May 31 issue)* accurately identifies decreased spending by the National Institutes of Health (NIH) as a factor in the decline of the number of physician-scientists, but it is simplistic to try to improve the situation by writing ...

To the Editor: Lachs et al. (May 31 issue)* neglected one important category of patients who often benefit from the forgiveness of coinsurance: physicians themselves when they become patients. This group of beneficiaries fits somewhere on the continuum ...

Medical genetics is a major avenue for the application of the techniques of molecular genetics to clinical medicine. This book fulfills the need for an integration of molecular with clinical genetics. It does so at a level intended for a student course in ...

This book presents a clear and concise review of the fundamental principles of physiology. It is divided into nine parts representing major divisions of physiology. Each part was written by a single author.

Brevity is a virtue of the book; the emphasis is ...

Unlike many scourges of mankind, endemic goiter is an entity whose features and cure were recorded almost simultaneously. As the author notes here, shortly after 2838 B.C. the Chinese Emperor Shen-Nung mentioned seaweed as an effective remedy for goiter. ...

Like it or not, quality assurance has become a very important concern of hospital managers and clinicians, and this concern is rapidly spreading to the ambulatory care arena. Benson and Townes have put together an easily read and well-organized book ...

"Landmark" is not too strong a word to use to describe the effect this book will have on sports medicine and the delivery of care in this area. The authors have produced a highly readable, well-researched resource destined to be a basic reference textbook ...

This textbook is the product of a successful collaboration between a statistician and a physician. The biostatistics coverage is standard; topics include descriptive statistics, probability and sampling, procedures for means (t-tests, analysis of variance,...

KEYSTONE SYMPOSIA

The following conferences will be held in Keystone, Colo., unless otherwise noted: "Molecular Basis of Oxidative Damage by Leukocytes" (Big Sky, Mont., Jan. 28—Feb. 3); "Gene Expression in Neuromuscular Development" (Jan. 24–30); "...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 6, 1988, issue of the British Medical Journal and the February 1988 issue of the Annals of ...