AUTOSOMAL dominant polycystic kidney disease is responsible for 6 to 9 percent of cases of end-stage renal disease in North America^{1 ' 2} and Europe.³ About 1 in 1000 persons carries a mutant gene for this condition.⁴ The disease can be diagnosed before ...

HYPERTENSION occurs in 50 to 75 percent of patients with autosomal dominant polycystic kidney disease before there is serious loss of renal function.^{1 2 3 4 5 6 7 8 9 10 11} Although many investigators have searched for potential pathogenetic mechanisms ...

MERCURY, in both its organic and inorganic forms, can be toxic to humans. Exposure to organic mercury during the late 1950s in Minamata, Japan, caused 41 deaths and at least 30 cases of infantile cerebral palsy.¹ In the 1940s, inorganic mercury added to ...

MICROVASCULAR complications begin to appear approximately five years after the onset of insulin-dependent (Type I) diabetes mellitus. The majority of patients have background retinopathy, and in nearly half these patients, proliferative retinopathy ...

TRANSFUSION-associated hepatitis has been reported to occur in 2.5 to 15 percent of patients who receive transfusions, and non-A, non-B hepatitis is known to account for the vast majority of these cases.^{1 2 3 4 5 6 7 8 9} The current incidence of ...

LASSA fever, first identified in northeastern Nigeria in 1969,¹ is endemic in much of western Africa. Mastomys natalensis, a rat that is common around human habitations in the region, is the host of enzootic Lassa fever virus.² The virus is spread to ...

CURRENT recommendations for lowering the cholesterol level to prevent coronary heart disease have focused largely on primary prevention and have paid less attention to the issue of lowering cholesterol in patients who already have coronary disease.^{1 2 3 4} ...

Presentation of Case

A 41-year-old man was admitted to the hospital because of a question of meningoencephalitis.

The patient was well until nine days earlier, in late May, when a severe, diffuse headache occurred, followed by anorexia, nausea, vomiting, ...

IN 1898 Tigerstedt and Bergman¹ observed a sustained pressor response after the infusion of a saline extract of renal tissue into a rabbit. This ultimately led to elucidation of the renin–angiotensin–aldosterone system, the components of which are ...

A SINGLE case of acrodynia led to the investigation described by Agocs et al. in this issue of the Journal ¹ and to the discovery that many more children had been exposed to mercury but did not contract what is now a rare childhood syndrome. It is a ...

Twenty years ago the arenavirus Lassa fever virus was identified as the cause of three serial, nosocomial cases of hemorrhagic fever in nursing personnel at a mission hospital in Jos, Nigeria. A subsequent outbreak there was thought to be a result of ...

To the Editor: In their article on sexually transmitted diseases in victims of rape, Jenny et al. (March 15 issue)* come to the conclusion "that the prevalence of preexisting sexually transmitted diseases is high in victims of rape." This conclusion is ...

To the Editor: The National Cholesterol Education Program has recommended that all adults lower their serum cholesterol levels to below 5.2 mmol per liter (200 mg per deciliter) in order to reduce the risk of atherosclerosis and its common clinical ...

To the Editor: The latest report on the Nurses' Health Study by Manson et al. (March 29 issue)¹ describes a positive association between the Quetelet index and coronary heart disease. The Quetelet index, however, may substantially misrepresent the most ...

To the Editor: Merimee et al.¹ have suggested that the short adult stature of African Pygmies is due "primarily, if not solely, to the absence of accelerated growth at puberty." They found that adolescent Pygmies had subnormal serum levels of insulin-...

To the Editor: A 59-year-old man with melanoma that had metastasized to his lungs, liver, and lymph nodes was enrolled in a Phase I trial with recombinant interleukin-2 (Glaxo). He received 1100 μg per square meter of body-surface area per day ...

To the Editor: Acute myocardial infarction soon after the use of cocaine has been well documented in the literature.^{1 2 3 4} However, acute myocardial infarction after amphetamine use has been rarely documented.⁵ We report a case of acute myocardial ...

To the Editor: As one of the physicians who was consulted by the mother of Baby L, I have both a procedural and substantive concern about the case presentation and discussion in the Occasional Notes article by Paris et al. (April 5 issue).*

Athough Baby ...

The field of coronary care medicine was created a quarter of a century ago. Virtually every large medical center and most community hospitals have a coronary care unit (or intensive care unit) where patients with known or suspected acute myocardial ...

Here, the editor has achieved a remarkably complete yet concise summary of the current practice of cardiac transplantation. Although the authors of the various chapters represent a number of different centers, there is a pleasing consistency of style that ...

About 12 years ago the advent of coronary balloon angioplasty ushered in a period of unprecedented growth in nonsurgical catheterization techniques not only to diagnose but also to treat cardiovascular disease. The ensuing years have spawned a ...

This paperback volume is a working reference for medical students, residents, nurses, technicians, and noncardiologists. The authors are seasoned teachers and clinicians who have tried to pace this edition at the breakneck speed of modern cardiology. For ...

A compelling argument for the creation of this book is made in the foreword and reinforced by the editor's preface. It is simply that most emergencies of cardiac or vascular origin must be managed in an exceedingly short time frame. Therefore, physicians ...

Here is an overview of the history, physiology, pharmacology, and effectiveness of cardiopulmonary resuscitation (CPR). Applications in pediatric and perioperative care and a brief discussion of the issues involved in forgoing CPR broaden the scope of the ...

An indication of the growth of respiratory care as a distinct calling since its beginning 40 years ago is the broad spectrum of topics covered in this textbook. Although mechanical ventilation and aerosol therapy remain major subjects, electrocardiography,...

CREIGHTON UNIVERSITY SCHOOL OF MEDICINE

The following conferences will be held: "Controversies and Clinical Management in High Risk Obstetrics" (New Orleans, Nov. 1–4); "Postgraduate Symposium on Anesthesiology" (Omaha, Nebr., Nov. 10 and 11); and the ...