TWENTY to 40 million children worldwide are estimated to have at least mild vitamin A deficiency, and nearly half are said to reside in India.¹ Controlled field trials in an area of endemic vitamin A deficiency in Indonesia revealed a reduction of 34 ...

MARFAN syndrome is one of the most common inherited connective-tissue disorders, with an estimated prevalence of 40 to 60 cases per million population.¹ It is inherited in an autosomal dominant fashion, although it is sporadic in 15 percent of cases.¹ The ...

PATIENTS with Stage III non-small-cell lung cancer are those who, after clinical or surgical staging (or both) at the time of diagnosis, have no demonstrable distant metastases but do have locally extensive or invasive disease or involvement of ...

THE Program on the Surgical Control of the Hyperlipidemias (POSCH) was a multi-clinic, randomized, prospective, secondary atherosclerosis-intervention trial designed to ascertain whether the reduction in plasma levels of total cholesterol and low-density ...

GROUP A β-hemolytic streptococcus is an uncommon but serious cause of postoperative wound infection. Group A streptococcus is isolated from less than 1 percent of all surgical-wound infections and causes less than 1 incisional-wound infection per 10,000 ...

THIS article reviews some currently important topics in ophthalmology, chosen either because they are of general interest or because they concern the ophthalmologic expressions of systemic diseases. We obviously cannot cover the entire field of ...

Presentation of Case

A 16-year-old boy was admitted to the hospital because of rapidly progressive hepatic failure.

There was a history of seizures that began at the age of 12 years, with partial complex and generalized tonic-clonic episodes; the seizures ...

Malnutrition and infectious diseases are a deadly combination in vulnerable preschool children. Morbidity and mortality from infections, particularly those causing acute and prolonged diarrhea or acute lower respiratory disease, are dramatically increased ...

Since nearly a century ago when the first professor of pediatrics in Paris, Antoine Marfan, described a young girl with long, spider-like fingers and other curious skeletal anomalies, understanding of the syndrome that now bears his name has expanded at ...

In 1984 Mackillop et al.¹ sent a questionnaire to physicians and surgeons in Ontario who treated lung cancer. The questionnaire asked the doctors to consider themselves as patients with lung cancer, as specified in a number of clinical scenarios, and to ...

In a preceding editorial¹ I suggested that changing the American health care system to address the basic causes of inflation would be a much better solution to the cost crisis than rationing. Here I wish to explain what sorts of changes I have in mind.

...

To the Editor: With reference to the article of Belongia et al. (Aug. 9 issue),* we have isolated and identified the peak E component of tryptophan that the authors mention as having a strong epidemiologic relation with the eosinophilia—myalgia syndrome.

To the Editor: Controversy has surrounded the question of HTLV-I (human T-cell lymphotropic virus Type I) infection and disease in Melanesia.^{1 2 3} We have identified a case of HTLV-I myeloneuropathy in a lifelong resident of the Solomon Islands,⁴ and we ...

To the Editor: Dalakas et al. (April 19 issue)¹ describe the development of a mitochondrial myopathy as a toxic effect of zidovudine therapy in patients positive for the human immunodeficiency virus (HIV). The authors' morphologic studies clearly show ...

To the Editor: In the review article by Dr. Harris, "Rheumatoid Arthritis: Pathophysiology and Implications for Therapy" (May 3 issue),¹ we appreciate the reference to our work on the long-term morbidity and mortality of rheumatoid arthritis.^{2 , 3} The ...

To the Editor: The April 26 issue of the Journal presented encouraging results by Knowles et al. regarding the beneficial effects of aerosolized amiloride in the treatment of cystic fibrosis.¹ The introduction and discussion sections of this article ...

To the Editor: Dr. Soll's informative and well-written review article on the pathogenesis of peptic ulcer and implications for therapy (March 29 issue)* contains one rather grave omission.

In his discussion of refractory ulcers — meaning ulcers, ulcer ...

To the Editor: The use of recombinant human erythropoietin has become almost universal in long-term hemodialysis. Reports of its efficacy in improving the anemia associated with renal failure and in patient rehabilitation have been punctuated by ...

To the Editor: The study from the International Centre for Diarrhoeal Disease Research, Bangladesh (May 10 issue)* provides important data that could improve the outcome of children with diarrhea. Two questions arise whose answers would allow clinicians ...

I had the opportunity to review the first edition of this book for the Journal in 1982, and it is a pleasure now to review the second. I have learned a good deal both times. Much has happened in the field of hepatology in these eight years, and the book ...

The 1990 version of Cecil Essentials of Medicine offers all students of medicine, both graduate and undergraduate, a useful synopsis of internal medicine. I have often seen this book toted around by medical students, and it is easy to understand why. In ...

This third edition of Stein's textbook of internal medicine has been published three years after the work was last revised. It competes with Harrison's, Cecil's, and Kelly's textbooks of internal medicine. In the preface the editor states that the aim of ...

This book deals with more than the irritable bowel syndrome. The first third of the book covers the neurophysiology and psychophysiology of the gut, brain—gut peptides and intestinal motility, and the effects of diet and drugs on intestinal function. The ...

This book replaces the first edition, published in 1981, entitled The Pathophysiology of Respiration (New York: John Wiley). Dr. Kryger, the editor and main contributor, calls on the talents of 14 other contributors to expand a description of normal ...

Marked progress has been made in the treatment of many cancers, so that physicians are now caring for a new cohort of patients — cancer survivors. This is very encouraging, particularly for diseases that were uniformly fatal not so long ago. Putting a ...

Although the title has changed and the editor has taken on an associate, Cancer Chemotherapy is in reality a second edition updating Chabner's Pharmacologic Principles of Cancer Treatment (Philadelphia: W.B. Saunders, 1982).

This book, like its ...

Thirty-two years have elapsed since the first edition of this book appeared. The material contained in this multiauthored fifth edition bears little resemblance to that initially provided by Dameshek and Gunz (New York: Grune and Stratton, 1958). ...

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

The following courses will be offered: "No Crystal Stair: Models for Successful Development of Afro-Americans" (Oct. 11 and 12); "8th Postgraduate Course in Medical Mycology (Dermatomycology)" (Oct. 12–14); "The ...

Just over two years ago, Congress created the U.S. Bipartisan Commission on Comprehensive Health Care to recommend legislative action to ensure all Americans coverage for health and long-term care. That commission — renamed the Pepper Commission in honor ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 6, 1988, issue of the British Medical Journal and the February 1988 issue of the Annals of ...