HIRSUTISM is one of the clinical manifestations of increased circulating levels of androgens in women. The increase in the androgen levels may be due to exogenous sources, increased adrenal or ovarian secretion, or increased peripheral conversion of weak ...

NONCLASSIC (late-onset) congenital adrenal hyperplasia is a frequent and relatively mild disorder of cortisol biosynthesis, characterized by a spectrum of clinical manifestations of postnatal androgen excess. These characteristics distinguish it from the ...

DESTRUCTION of the brain is one of the most fearsome consequences of infection with the human immunodeficiency virus (HIV). Many patients with the acquired immunodeficiency syndrome (AIDS) become demented, and at autopsy more than 90 percent have ...

THROUGH recent progress in chemotherapy and bone marrow transplantation, acute leukemia has become a curable disease. It has become clear, however, that intensive therapy is required to effect a cure, especially in acute myelogenous leukemia.^{1 2 3} ...

THERE is little agreement about the effectiveness of supplemental calcium in retarding the rate of bone loss in postmenopausal women. Such supplements have been found to slow bone loss in some studies^{1 2 3 4 5} but not in others,^{6 , 7} and the effect of ...

AMERICAN interest in the Canadian health care system is growing rapidly for two principal reasons.^{1 2 3} First, costs have escalated in the United States to such an extent that health care now accounts for approximately 11.5 percent of the gross national ...

IN an editorial in the Journal in 1982,¹ Charles Carpenter wrote:

We physicians all presumably accept the "primum non nocere" principle. On the basis of... studies... this principle would dictate that oral rehydration be accepted not only as an equal, but ...

Presentation of Case

A 66-year-old man was admitted to the hospital because of progressive muscle weakness and paresthesias.

The patient was in excellent health until two days before admission, when he mowed his lawn without difficulty; that evening he ...

Hirsutism is a common condition that presents unique diagnostic and therapeutic challenges, and the assessment of patients with hirsutism requires both clinical and biochemical evaluation. The former is relatively straightforward; the latter, however, can ...

Suddenly everyone is talking about rationing. First brought to public attention in this country by Schwartz and Aaron's study of the allocation of hospital services in the United Kingdom,^{1 , 2} rationing is now widely advocated as the only effective way to ...

The Commission on Health Research for Development, an independent international initiative, was launched in 1987 to study the status, effect, and needs of research on the health problems of developing countries. The commission has now released its final ...

To the Editor: In their case report of a failure of zidovudine prophylaxis after exposure to human immunodeficiency virus type 1 (HIV-1) (May 10 issue),¹ Lange and colleagues fail to mention what is perhaps the most likely explanation for the observed ...

To the Editor: The letter from Ries et al. (March 1 issue)¹ regarding a disseminated cutaneous Mycobacterium marinum infection in a patient with AIDS prompted this correspondence. In our case, a patient with AIDS had a mixed disseminated cutaneous ...

To the Editor: The article by Ottesen et al. (April 19 issue)¹ on ivermectin in bancroftian filariasis, as well as the accompanying editorial,² seems to avoid the central issue in the treatment of this disease: the killing of the adult worm, which is the ...

To the Editor: Desynchronizations wrought by international travel and night work are symptomatic as well as measurable. The simple yet cleverly devised experiment of Czeisler and his colleagues (May 3 issue)* demonstrates the effectiveness of a ...

To the Editor: Surprisingly, the Canadian multicenter study of the efficacy of a combination of lecithin and tetrahydroaminoacridine (THA) in the treatment of Alzheimer's disease (May 5 issue)¹ failed to include an untreated control group; all patients ...

To the Editor: Patients with severe and refractory aplastic anemia who cannot be offered bone marrow transplantation and who do not respond to antilymphocyte globulin therapy represent a difficult therapeutic problem. We tried combined therapy with ...

To the Editor: Calcium carbonate is the preferred calcium supplement because calcium absorption from this salt is as good as that from milk and other calcium salts,¹ it is the least expensive form,² and its lower molecular weight allows the use of a ...

To the Editor: Cancer registries do far more than track the incidence of cancer; they also monitor key staging and prognostic information.¹ The recording and monitoring of such data establishes features that distinguish early-stage from late-stage cancer ...

To the Editor: Redelmeier and Tversky (April 19 issue)* present results of several elegant experiments that highlight the observed discrepancy between aggregate and individual perspectives in medical decision making, but they suggest that this ...

Today's patients are expected to accept responsibility, become part of the medical process, and give informed consent. Lewis urges them to become as well informed as they can before making a choice. This book is designed to help laypeople in decision ...

With less time in the medical school curriculum for gross anatomy, there is added emphasis on advanced courses in surgical anatomy. In response, a number of new books and modern editions of older ones have been published in the past decade. This second ...

This book details the anatomical considerations, pathophysiology, diagnostic approach, and operative technique employed in the management of surgical disease in its broadest definition. It is intended to serve as a guide for the surgeon in training and a ...

Here is a multiauthored, comprehensive treatise on the care of acutely injured patients; the scope is all inclusive. The early chapters address broader issues in the care of patients with trauma, such as the impact of trauma on the health care system and ...

Head injuries are a leading cause of death and disability in young adults and adolescents. The outcome of treatment in the most severely injured is often far from satisfactory. The care of head-injured patients is usually not in the hands of the most ...

This second edition of Greenhalgh's atlas is outstanding. Many surgical atlases are available, and several specialize in vascular surgery. This atlas is extremely well illustrated. One can generally get the concept of the procedure from the pictures ...

This book is a sequel to Operative Techniques in Vascular Surgery, by the same editors (New York: Grune and Stratton, 1980). It represents the latest in an extensive line of publications on vascular topics by this prolific editorial team. A survey of ...

Scott and 26 authors have contributed to this textbook on arthroscopy of the knee. He acknowledges the difficulty of assembling a book on state-of-the-art materials. This is a formidable task in the subspecialty of knee arthroscopy, in which rapid ...

This book is a pleasant surprise. While there are many single-volume textbooks of otolaryngology suitable for the resident or medical student, this book distinguishes itself by emphasizing problems encountered daily in practice. Many of these topics are ...

Pharmacology and Substance Abuse

Molecular Aspects of Chemotherapy. (Pharmacology and Therapeutics.) Edited by Edward Borowski and David Shugar. 220 pp. New York, Pergamon Press, 1990. $70.

The NMDA Receptor. Edited by J.C. Watkins and G.L. Collingridge. ...

CALL FOR ABSTRACTS

Abstracts are now being accepted for the "9th International Congress of Radiation Research," to be held in Toronto, July 7–12. Deadline for junior investigators awards is Oct. 15; deadline for submission of abstracts is Jan. 15, 1991.

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