Pneumocystis carinii pneumonia (PCP) is the most frequent life-threatening opportunistic infection leading to the diagnosis of the acquired immunodeficiency syndrome (AIDS), having affected at least 70,000 persons in the United States since 1981.¹ In ...

Pneumocystis carinii pneumonia is the most common opportunistic infection in patients with the acquired immunodeficiency syndrome (AIDS), as well as the most common index diagnosis.^{1 2 3 4} Although both trimethoprim–sulfamethoxazole and pentamidine are ...

Exposure to environmental tobacco smoke has been postulated to have an adverse effect on lung function^{1 2 3 4} and growth^{5 6 7 8 9 10 11} in normal children. There is a dose-dependent relation in the frequency of respiratory tract infections in infants and ...

Beta carotene is a plant-derived carotenoid with pro—vitamin A (retinol) activity that has been proposed as a possible preventive agent against cancer.^{1 , 2} Numerous case–control studies have shown an inverse relation between the risk of cancer and the ...

Cancers of the lung, esophagus, and head and neck are expected to account for nearly one third of the 500,000 deaths due to cancer that have been predicted to occur in the United States in 1990. Tobacco use, which contributes to most of these cancers, ...

Chronic idiopathic thrombocytopenic purpura is an autoimmune disorder in which the destruction of autologous platelets is mediated by autoantibodies directed against platelet-surface constituents.¹ Glycoproteins IIb and IIIa, which exist in the platelet ...

Replacement of the arthritic knee now has clinical results that equal or exceed those of hip replacement in terms of pain relief, satisfactory function, and survival of the implant after 10 years.^{77 , 78} These results have not been achieved by any one ...

Presentation of Case

A 32-year-old woman was admitted to the hospital because of a sensorimotor neuropathy with eosinophilia and asthma.

The patient was well until three years earlier, when asthma developed. Ten months before entry she had pneumonia, with ...

The Journal is receiving a growing number of epidemiologic reports of associations between diseases and possible risk factors. The risk factor in question is often a habit or type of behavior, some element of diet or lifestyle that can presumably be ...

With the aging of the population and the continued fall in rates of mortality from cardiovascular diseases, cancer will emerge soon after the year 2000 with the dubious distinction of being the leading cause of death in the United States. Unfortunately, ...

Clozapine is a new neuroleptic drug that was released for clinical use in the United States in February 1990 under the trade name Clozaril. Its availability is limited by an expensive mandatory system for distributing the drug and monitoring side effects —...

DEATHS

Axelrod — George Axelrod, M.D., formerly of Clinton, died on June 29. He was 81.

Dr. Axelrod received his degree from Tufts College Medical School in 1932. He was a member of the American Medical Association. Dr. Axelrod was a 50-year member of the ...

To the Editor: A demonstration of the effectiveness of shorter therapy for deep venous thrombosis has been eagerly awaited at all levels of the cost-aware health care system. The study by Hull and colleagues (May 3 issue)* provides some affirmative ...

To the Editor: Coller's detailed review article on platelets and thrombolysis (Jan. 4 issue)¹ discussed possible physiologic mechanisms that may explain why some patients with myocardial infarction are resistant to thrombolysis. Coller did not mention, ...

To the Editor: In a recent study, Moran et al. (April 26 issue)¹ demonstrated that misoprostol, a prostaglandin E₁ analogue, markedly reduced the incidence of acute rejections in renal-transplant recipients treated with cyclosporine and prednisone. The ...

To the Editor: Fludarabine (9-β-D-arabinofuranosyl-2-fluoroadenine) has recently been approved with orphan-drug status for therapy of chronic lymphocytic leukemia. The rates of response are 64, 58, and 50 percent, respectively, for chronic lymphocytic ...

To the Editor: There is much concern today over the relation between exposure to environmental tobacco smoke and lung cancer. Some 20 cohort and case–control studies have compared lung-cancer incidences in nonsmoking women married to smokers with those ...

To the Editor: Although psychological and behavioral effects associated with the administration of anabolic-androgenic steroids were first noted 50 years ago,¹ recent reports suggest that affective and psychotic syndromes, some of violent proportions, ...

To the Editor: Staying too long in a spa pool can result in overheating, which in pregnant women may possibly cause fetal malformations.^{1 , 2} But how long is too long? Possible safeguards could include time limits or the spa user's subjective discomfort, ...

To the Editor: The recent article by Hemenway et al. (April 12 issue)¹ makes assumptions that are not correct, looks at biased data, and therefore comes to questionable conclusions. Although the authors controlled for physician and season, the specific ...

To the Editor: After years of interviewing candidates for house-staff training, it becomes apparent that standard questions elicit standard responses, and the conduct of yet another interview seems an insurmountable task. How many times can one ask, "Why ...

This is a new edition of a multiauthored textbook intended for two audiences: medical students or physicians interested in the scientific basis of clinical neurology, and graduate students or scientists in the field of neurobiology. The 23 chapters are ...

It takes a lot of courage to write or even edit a book on Alzheimer's disease. Because of the rapid changes in this field, the author's work can easily fall behind the pace of research before the publishers get the book to the bookstore. This may not be ...

Stoudemire has edited a textbook of psychiatry for medical students that is a companion to his earlier book, Human Behavior: An Introduction for Medical Students (Philadelphia: J.B. Lippincott, 1990). The present book introduces medical students to ...

We are the creatures of language and awareness, the ones whose biologic makeup makes possible the writing of a review such as this, not to mention a book such as Gerald Edelman's The Remembered Present, an effort to explain what happens in the brain that ...

It took a task force of the American Psychiatric Association, assisted by 26 panels and hundreds of authors and reviewers, seven years to produce this massive guide to the treatment of psychiatric disorders. The effort was surrounded by controversy. Many ...

Sir Cyril Burt died in 1971 after an illustrious career in which he was acclaimed as the father of British psychology. He was the first psychologist in Britain to be knighted. The focus of his work was on the nature of intelligence and its relation to ...

The receipt of these books is acknowledged, and this listing must be regarded as sufficient return for the courtesy of the sender. Books that appear to be of particular interest will be reviewed as space permits.

Addresses of most overseas publishers ...

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EUROPEAN ACADEMY OF DERMATOLOGY AND VENEREOLOGY

The 2nd congress will be held ...

On September 19, 1990, the Institute of Medicine of the National Academy of Sciences released a comprehensive report on drug-treatment programs.* The legislation authorizing the report had asked for recommendations on support for the rehabilitation of ...