GYCLOSPORINE is a novel immunosuppressive agent that has greatly enhanced long-term survival after organ transplantation¹ and has proved beneficial in the treatment of many autoimmune diseases.^{2 3 4 5} However, cyclosporine has also produced a new form of ...

NUMEROUS studies have demonstrated an association between cerebrovascular disease and the use of cocaine.^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34} The appearance in 1983 of commercially prepared ...

IMMUNODEFICIENCY following myeloablative chemoradiotherapy can foster a variety of opportunistic infections after bone marrow transplantation.^{1 2 3 4} Cytomegalovirus is the most frequent fatal infection and is especially common among patients seropositive ...

AS the survival of patients with thalassemia major has improved, extending into the third and fourth decades of life,^{1 2 3} growth, sexual development, and fertility have become important issues to be addressed. With the introduction of transfusion ...

CHROMOSOMAL analysis in malignant disease has increased in importance during the past decade. Analysis of the Philadelphia chromosome in chronic myelocytic leukemia¹ and of the (14;18) translocation in follicular lymphomas² has led to the identification ...

HUMAN T-cell lymphotropic virus Type I (HTLV-I) is a retrovirus identified as the etiologic agent of adult T-cell leukemia and lymphoma.^{1 , 2} More recently, HTLV-I infection has been implicated in the causation of chronic progressive myelopathies, such as ...

THE indications for and benefits and limitations of modern total hip replacement have been well defined by the years of experience since the first operation in 1962.¹ The operation, which is by far the most successful surgery for patients with advanced ...

Presentation of Case

A 28-year-old man was admitted to the hospital because of increasing dyspnea, a dry cough, and fever.

The patient was well until four months earlier, when a lymph node, 10 cm, was palpated in his right axilla. Microscopical ...

Cyclosporine has dramatically advanced immunosuppressive therapy following organ transplantation, but this advance has been accompanied by a high incidence of hypertension in patients receiving this drug, particularly heart-transplant recipients. In this ...

The newspaper headlines in early June about Dr. Jack Kevorkian and the "suicide machine" with which Mrs. Janet Adkins took her life captured the attention of the nation and stimulated anew the long-running public debate over assisted suicide and ...

To the Editor: Both Shortell and McNerney¹ and Kinzer² in their Sounding Board articles (Feb. 15 issue) dismiss too quickly the possibility of a universal health care plan. One feasible route to this elusive goal has so far largely escaped attention: ...

To the Editor: Volberding et al. (April 5 issue)* reported that zidovudine (azidothymidine, or AZT) is effective in delaying progression to the acquired immunodeficiency syndrome (AIDS) in asymptomatic patients infected with the human immunodeficiency ...

To the Editor: The work of Saour et al. on anticoagulation in patients with prosthetic heart valves (Feb. 15 issue)¹ is to be commended for its attempt to address the problem of the appropriate intensity of anticoagulation in such patients. The authors ...

To the Editor: Brain natriuretic peptide (BNP), first isolated from the brains of pigs,¹ has a striking similarity to atrial natriuretic peptide (ANP) both in structure and in peripheral and central actions.^{1 2 3 4} BNP is also a cardiac hormone in pigs⁵ ...

To the Editor: The paper on adrenocortical carcinoma by Luton et al. (April 26 issue)¹ included a description of the results of mitotane therapy (Roussel–UCLAF) in 59 patients. The drug was given in capsules containing 0.5 g of micronized mitotane mixed ...

To the Editor: We recently cared for a 24-year-old man admitted to the emergency room with symptoms of substernal chest discomfort, breathlessness, difficulty swallowing, and change in speech. The patient stated that he had been well until the evening ...

To the Editor: Whenever government administrators prescribe unnecessary layers of busywork, it adds to the cost of medical care without mending the whole problem. Nowhere is this more evident than in the nursing home.

We present one example in a nursing ...

To the Editor: Consumers are not the only ones who are caught repeating misinformation. Erroneous advice found in materials in current use from the American Heart Association¹ and the American Cancer Society,² distributed nationally in a videotape³ and ...

This book comes from the Mayo Clinic and has 83 contributors. It is large but well balanced, with a good historical section, a fine (143-page) section on structure and function, and an appropriate distribution of clinical topics. A review of specific ...

This large textbook, with 66 eminent contributors, covers the whole field of cardiology with excellent and comprehensive discussions. There are 50 pages on pericardial diseases, for example, and 65 on hypertension. An appropriate balance between basic ...

This book is the product of 70 contributors, most of whom are or were associated with Massachusetts General Hospital. Unfortunately, the potential advantages of increased cohesiveness provided by such an arrangement have not materialized, and there is no ...

This two-volume textbook is unusual, differing from all the others surveyed here in its concentration on the basic-science aspects of the cardiovascular system. The three major sections are devoted to principles and methods of cardiovascular research, ...

The publication of seven editions of a cardiology textbook must be a record, and it testifies to a high level of acceptance. The current edition clearly benefits from the years of experience of the authors. There are 197 contributors, and they have ...

Here is a new book from overseas, competitive with those from the United States in size (1709 pages) and scope. All but 3 of its 62 contributors are from the United Kingdom. Their style of writing is decidedly superior. There is an admirable discussion of ...

This book was published in two loose-leaf volumes with the expectation of periodic replacement of outdated chapters. It is our understanding that it is to be reissued in a conventional format. Currently, it is difficult to locate copies. The book is ...

It is extraordinary today to find that one physician has written a 1922-page textbook of heart disease single-handedly (the author concedes only "assistance" from six colleagues, none of whom is listed as a contributor). Essentially then, this is a one-...

Biomedical Science

Anatomy as a Basis for Clinical Medicine. Second edition. By E.C.B. Hall-Craggs. 593 pp., illustrated. Baltimore, Urban and Schwarzenberg, 1990. $42.50.

Atlas of Ophthalmology in Dogs and Cats. By Ingo Walde, Ekkehard H. Schäffer, and ...

ORAL CHELATION

The 2nd international conference will be held in Bombay, India, Nov. 2 and 3.

Contact Dr. M.B. Agarwal, 303 Doctors Ctr., Kemps Corner, 135 August Kranti Marg, Bombay 400 036, India; or call (91) 22 811- 5504.

CHILD NEUROLOGY

The joint ...

The human immunodeficiency virus (HIV) epidemic has exerted an uneven effect on health care delivery in the United States. Five states have almost 65 percent of the 140,000 diagnosed cases of the acquired immunodeficiency syndrome (AIDS), and five cities ...