PROSTATE cancer is the most prevalent cancer in men, the most frequently diagnosed cancer, and the second most frequent cause of death due to cancer in American men.^{1 2 3} The approach to treatment varies and is dependent on the extent of cancer at the ...

ALL human herpesviruses establish latent infection. The human herpesviruses — in particular, Epstein–Barr virus, herpes simplex virus, and varicella–zoster virus — have served as models for the study of latency. Varicella–zoster virus causes chickenpox (...

THE 1972 Surgeon General's report dealt with the health consequences of passive smoking or environmental tobacco smoke for the first time.¹ In 1986 the entire report was devoted to the issue; it concluded that "involuntary smoking is a cause of disease ...

CAUSTIC materials are widely used in crystalline and liquid form for cleaning in the home and in industry, but they constitute a public health hazard. Despite legislation to limit the concentration of such materials and make their containers childproof, ...

THIS report describes four adults with severe axillary lymphadenitis, a streptococcal infection that is now unusual. The syndrome was characterized by the acute onset of fever, severe pain in the axilla, and in three patients moderate-to-marked edema of ...

AFTER disappearing for a decade, universal health insurance has returned to state and federal agendas. Massachusetts, despite budgetary and political obstacles, struggles on in its attempt to implement the first state universal-coverage plan.¹ Hawaii ...

THE slow-reacting substance of anaphylaxis was recognized as a discrete biologic entity ^{1 , 2} three to four decades before it was chemically defined as three specific cysteinyl leukotriene products of the 5-lipoxygenase pathway.^{3 4 5 6 7} In the interim, ...

Presentation of Case

A 42-year-old woman was admitted to the hospital because of chylous ascites, lymphadenopathy, and weight loss.

The patient was well until three years earlier, when she was evaluated elsewhere because of a right pleural effusion. A ...

According to the American Association of Poison Control Centers, in 1988 poisoning in children under six years old made up 62 percent of all reported poisonings, was more common in boys than in girls, was usually accidental, and was often asymptomatic or ...

The national discussion concerning decision making for incompetent patients began with the 1976 case of Karen Ann Quinlan. Because she had been left in a persistent vegetative state after two periods of anoxia, her parents sought court authorization to ...

Technology assessment is not a new phenomenon in medicine. The most able and conscientious physicians have always sought to understand the effects of the interventions they apply.¹ With the development of clinical research, attempts to establish safety ...

To the Editor: When matched with biopsy and operative pathological reports, our results,^{1 2 3} as well as those from certain laboratories,^{4 5 6} demonstrate that our nuclear magnetic resonance (NMR) technique accurately detects cancer. Others have come ...

To the Editor: The article by Albin and colleagues (May 3 issue)¹ reporting abnormalities of striatal projection neurons and N-methyl-D-aspartate receptors in presymptomatic Huntington's disease provides new insight into the early neurochemical pathology ...

To the Editor: In the April 5 issue of the Journal, Klempner et al.¹ describe changes in human neutrophil function tested under ex vivo conditions in patients with metastatic cancer who were treated with interleukin-2. We agree with the authors that of ...

To the Editor: Because of early concerns about lens opacities induced by lovastatin,¹ the lenses of patients with hypercholesterolemia were evaluated as part of a broader study that assessed the long-term efficacy and safety of lovastatin. We summarize ...

To the Editor: We have treated two male patients in the past year who had paresthesia of the extremities after the ingestion of astemizole, a new class 1 antihistamine. One such patient, a 45-year-old man, was first seen in 1984 for perennial seasonal ...

To the Editor: Stern et al. (April 19 issue)¹ reported an increased risk of genital cancers in patients with psoriasis who had undergone therapy with oral methoxsalen and ultraviolet A radiation (PUVA). I recently reported the occurrence of squamous-cell ...

To the Editor: Over the years, the Journal has published several letters describing afflictions related to hobbies, occupations, and habits. Alliteration of the condition with the body part affected seems to be important in the title of the letter (two ...

To the Editor: Do-not-resuscitate (DNR) orders for patients are widely recognized and used in most hospitals in the United States; however, the rapid identification of patients who fall into this category is sometimes difficult and confusing when they ...

On June 25, 1990, the U.S. Supreme Court issued its long-awaited decision in the case of Nancy Cruzan, the first "right to die" case to come before it. The purpose of this statement is to clarify the meaning of that case in order to prevent ...

Frank Oski's prolific career as a contributor to the literature of pediatrics has culminated in this book, edited with the assistance of DeAngelis, Feigin, and Warshaw. Described by the editor as "five books in one," this major new textbook has five parts,...

This book was designed to present important medical information in a more concise way than is possible in a standard textbook of pediatrics. The stated goal of the editors was to provide sufficient information to enable the reader to gain a basic ...

While several textbooks on disorders of fluid and electrolytes in infants and children have appeared over the past 50 years, this multiauthored book is the first to appear in nearly a decade. The book emphasizes the fundamentals of fluid and electrolyte ...

This is the revised and expanded second edition of the book first published 12 years ago. It is presented in five sections, covering the newborn, the "settled baby" (up to 6 months), the older baby (6 to 12-months), the toddler(l to 2 1/2 years), and the ...

Adolescent Medicine: State-of-the-Art Reviews was developed by members of the Section on Adolescent Health of the American Academy of Pediatrics as one component of a continuing-education plan for pediatricians. This hard-bound journal, published three ...

Imagine a textbook of pediatric pulmonary medicine published in 1990 that does not discuss computerized tomography or magnetic nuclear resonance imaging. This is just what the authors of this clinically oriented Australian book have produced. This book ...

Pharmacology and Substance Abuse

Alcohol and the Family: Research and clinical perspectives. Edited by R. Lorraine Collins, Kenneth E. Leonard, and John S. Searles. 386 pp. New York, Guilford Press, 1990. $40.

Azapropazone: 20 years of clinical use. ...

MEDICAL EDUCATIONAL COUNCIL OF PENSACOLA

The following will be held in Pensacola, Fla.: "16th Annual Gulf Coast Internal Medicine Seminar: 'New Treatment Modalities' " (Sept. 21 and 22); "Current Concepts in the Diagnosis & Treatment of Adult Heart ...

Lack of Efficacy of Hydergine in Patients with Alzheimer's Disease (August 16, 1990; 323:445–8). On page 447, in Table 1, in the column headed "Hydergine-LC, Change," the mean (±SE) value for the WAIS Digit Symbol Substitution Task should have been −8.85±...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 6, 1988, issue of the British Medical Journal and the February 1988 issue of the Annals of ...