IN middle and late adulthood all people experience a series of progressive alterations in body composition.¹ The lean body mass shrinks and the mass of adipose tissue expands. The contraction in lean body mass reflects atrophic processes in skeletal ...

Tay-sachs disease (G_M2 gangliosidosis, type 1, reviewed in references 1 and 2) is an autosomal recessive lysosomal-storage disorder that results from a deficiency of the α subunit of hexosaminidase A.^{3 , 4} In the absence of hexosaminidase A, G_M2 ...

Demographers have repeatedly noted reductions in the birth rate during spring in nonequatorial regions with warm climates.^{1 2 3 4} Could summer heat nine months earlier have caused the quality of semen to deteriorate and result in a diminished rate of ...

During the past two decades there has been a substantial improvement in prognosis for patients with acute lymphocytic leukemia in childhood. However, despite a success rate of more than 90 percent in inducing remission, 30 to 40 percent of children ...

The importance of the endothelium in modulating the activity of vascular smooth muscle and therefore in regulating vascular tone was first suggested by the pioneering studies of Furchgott and Zawadzki.¹ These authors reported that the damage or absence of ...

The clinical and biochemical heterogeneity of the mitochondrial myopathies is now well established.^{1 , 2} Recent work has focused on identifying the molecular basis of these disorders and has demonstrated specific deficiencies of nuclear-encoded ...

William harvey, when studying the circulation of the blood, must have recognized that "In sound and living vessels the blood remains fluid, but it coagulates in dead ones" (Ernst Brücke, 1857). Joseph Lister (1909) provided further evidence for an active ...

Presentation of Case

A 63-year-old woman was admitted to the hospital because of severe substernal pain.

The patient was in a stable state of health until 2 1/2 years earlier, when chest pain developed while she was walking uphill and disappeared after ...

IN addition to promoting linear growth in prepubertal children, growth hormone is often described as having anabolic, lipolytic, and diabetogenic properties. These descriptions are based on the results of diverse short-term studies of humans, animals, and ...

During the past two decades, we have become increasingly knowledgeable about human spermatogenesis, its physiologic control, methods of altering it, and the pathologic factors that impair it. We remain ignorant, nonetheless, about many factors that ...

IN this issue we publish a revised "Information for Authors" page, including three changes that should interest readers as well as authors.

First, we are adopting a new, structured format for abstracts. Journal abstracts will henceforth consist of four ...

DEATHS

Andosca — John Baptist Andosca, M.D., of Lynn, died on March 30 at the age of 83.

Dr. Andosca received his degree from the Registrable Qualifications Granted by the English Conjoint Board, United Kingdom, in 1934. He was a member of the American ...

To the Editor: The article by Frezza et al. (Jan. 11 issue)¹ demonstrates higher blood ethanol concentrations in women than in men because of a decreased activity of gastric alcohol dehydrogenase (ADH). However, there is one important point we would like ...

To the Editor: The article by Lemna et al. (Feb. 1 issue)¹ furthers the evaluation of the ΔF508 mutation, which is associated with some cases of cystic fibrosis. Although its real effect may be to help in documenting the substantial clinical variation ...

To the Editor: In studies of blood transfusion, a relation has been described between the transmission of the hepatitis B virus and the spread of hepatitis C virus.^{1 2 3 4 5 6 7} Antibodies to both viruses have been found in the serum of infectious blood ...

To the Editor: The features of cisplatin-induced peripheral neuropathy were described extensively in the editorial entitled "Cisplalin Neurotoxicity" (Jan. 11 issue).¹ Ototoxicity is also a common complication of cisplatin therapy, however, and focal ...

To the Editor: Scherrer et al. (March 1 issue)¹ describe an episode of vasovagal syncope after the infusion of a nitrovasodilator agent in a man with a heart denervated by transplantation. From direct recordings of activity in sympathetic fibers in the ...

To the Editor: I have for years wondered about the reasons for the nearly universal practice of measuring capillary blood glucose by finger stick. The fingertip is one of the most densely innervated and sensitive areas of the body, but as far as is known ...

My Dearest Editor: A recent letter I received from the New Jersey Department of Environmental Protection, Division of Solid Waste Management, Bureau of Special Waste Planning, addressed to "Dear Regulated Medical Waste Generator," has prompted me to ...

The path to medical immortality is either through discovering something of importance or getting one's name affixed to a relatively common disease, the latter being Paget's way. Here, the author demonstrates that Paget merits our attention for more than ...

This ninth edition, the second under the direction of Schwarlz and Ellis, marks the 50th anniversary of Mahigot's classic. Over this period, the book has acquired a historical significance. This edition is a tribute to the talents of earlier distinguished ...

It is stated that knowledgeable observers who wish to evaluate a surgeon's operative skills need only watch that surgeon perform an inguinal herniorrhapy. General surgeons would agree that in most respects this belief is axiomatic. Understandably, it ...

This survey of anesthesiology has been prepared by almost 100 British, American, Canadian, and Australian authors, whose reports are presented in 81 often abbreviated chapters. These two volumes together weigh more than 12 pounds, yet when they are read, ...

This book fills a distinct void in the literature on anesthesia by bringing together in one volume material that could only be found previously in textbooks of general anesthesia or in journals. The editor is to be congratulated for selling a style. ...

This second edition presents a well-written synopsis of modern anesthesiology practice. Although aimed at medical students and residents, the book provides an overview of the discipline and should be of value to a wide range of physicians and nurses.

...

This textbook was first published in 1949 by Evans, an expert clinician at St. Bartholomew's Hospital in London,

The last third of the 150-year history of general anesthesia has been marked by a move from the use of the most simple equipment, such as the ...

Notices submitted for publication should contain a mailing address and phone number of a contact person or department. We regret we are unable to publish all Notices received.

HEALTH MANAGEMENT MBA FELLOWSHIP

The Graduate School of Business at Stanford ...

Esophageal Tear Caused by a Tortilla Chip (May 10, 1990;322:1399–400). On page 1400, the firsl sentence of the last paragraph should have read: "... only two cases of esophageal laceration caused by food, and both were due to corn chips.1–2" We regret the ...

Interventional Radiology in the Chest and Abdomen (May 10, 1990; 322:1364–74). On page 1365, Figure 1 and its legend should have appeared as follows:

Cystic fibrosis is an autosomal recessive genetic disorder clinically characterized by chronic lung disease and pancreatic insufficiency. Median survival is 25 years, with an increasing number of patients surviving into their 30s. This disease affects ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document appears in the February 6, 1988, issue of the British Medical Journal and the February 1988 issue of the Annals of ...