HIGH blood pressure is a problem that affects millions of Americans. It is an important risk factor for both cerebrovascular and coronary heart disease, major diseases of industrially developed contemporary societies. Recent studies raise questions about ...

ALTHOUGH the relation between dietary intake of fatty acid and plasma cholesterol levels has been studied for more than 20 years,^{1 2 3} the most effective dietary approach for reducing plasma concentrations of total cholesterol while achieving an optimal ...

MEASLES remains a major cause of childhood morbidity and mortality in developing countries. It is estimated that more than 2 million children die of measles each year.¹ Measles also causes blindness, diarrhea, and malnutrition in many children who survive ...

ELECTRONIC fetal-heart-rate monitoring is widely used in the United States¹ to reduce perinatal mortality and the incidence of disorders of neurologic development.² The rationale is based primarily on retrospective studies of perinatal mortality and ...

THE clinical discipline of occupational medicine, largely unstudied, untaught, and unpracticed in major medical centers as recently as a decade ago, underwent unprecedented rejuvenation in the 1980s. Spurred by national regulatory programs and ...

HYPOTENSIVE states are well known to activate the sympathetic nervous system, leading to reflex vasoconstriction and tachycardia.¹ Hypovolemic hypotension, however, can be accompanied by paradoxical withdrawal of sympathetic drive, leading to vasodilation ...

THE year 1989 marked the 100th anniversary of the publication of a seminal paper in the study of the biology of human tumors. Stephen Paget, having collected the autopsy records of 735 patients who died of breast cancer, noted that the majority of the ...

Presentation of Case

A 39-year-old man was admitted to the hospital because of left-sided abdominal pain, malignant hypertension, and proteinuria.

The patient was in excellent health until 27 days earlier, when he experienced the acute onset of pain in ...

In the continuing search for better and safer ways to control hypertension, various nondrug therapies are widely advocated, and potassium supplements are often listed in the "nondrug prescription." ¹ Grimm et al.,² reporting in this issue of the Journal, ...

Intrapartum electronic fetal-heart-rate monitoring was introduced in the United States in the early 1970s after studies supported the existence of a correlation between patterns of fetal heart rate and signs of fetal hypoxia — specifically, intrapartum ...

Almost everyone agrees that the present malpractice liability system is not working, but there is no consensus on what should be done about it. Meanwhile, costs to physicians and the public continue to rise. According to a recent study, premiums plus the ...

Physicians believe that professional liability is one of the most severe problems they face today. This has been confirmed by surveys conducted by the American Medical Association, the American College of Surgeons, and state medical societies.^{1 2 3}

At a ...

DEATHS

Ashe — Allan Murray Ashe, M.D., of Pittsfield, died on January 25. He was 79.

Dr. Ashe received his degree from the College of Physicians and Surgeons in 1937. He was a member of the American Medical Association, the American Society of ...

To the Editor: The article by Schoenbaum et al. (Sept. 28 issue)* provides some very interesting demographic observations about some people in a section of New York City who are positive for the human immunodeficiency virus (HIV). There is, however, at ...

To the Editor: The increasing prevalence of AIDS has heightened interest in atypical mycobacterial infections.¹ Mycobacterium avium complex is the usual cause in patients with AIDS.^{2 3 4} M. marinum, which typically causes a self-limited, cutaneous ...

To the Editor: Persistent parvovirus B19 infection has been described in patients with constitutional or acquired immunodeficiency.^{1 2 3 4} We report a relapsing course of erythroid hypoplasia due to parvovirus infection in an infant whose immunologic ...

To the Editor: Ribavirin therapy for infections with respiratory syncytial virus (RSV) is increasingly controversial.^{1 , 2} Important concerns have been raised about its efficacy.^{3 4 5} Even the suggestion that ribavirin is efficacious under certain ...

To the Editor: Allen et al. (Aug. 31 issue)* have characterized four patients with acute eosinophilic pneumonia, a syndrome that appears to be distinct from other types of idiopathic eosinophilic lung disease. We describe an HIV-infected patient who ...

To the Editor: The paper by Brynskov et al. (Sept. 28 issue)¹ is clearly important as the first published randomized, controlled trial of oral cyclosporine in Crohn's disease. The editorial by Sachar² asks whether this is a step backward or a leap ...

To the Editor: As senior health adviser to Jesse Jackson's 1988 campaign and as a participant in many of the developments that Blumenthal and Berenson refer to in their article "Health Care Issues in Presidential Campaigns" (Sept. 28 issue),¹ I disagree ...

To the Editor: Your description of the peer-review process at the Journal (Sept. 21 issue)* deals superficially with the issue of blinding reviewers to authorship. The statement that "most manuscripts contain within them some ineradicable clues to ...

While several books recently discussed in these columns have sought to review or make recommendations about the medical-malpractice enigma in the United States, few have done it as well as this one. Here is a book that makes recommendations, with very ...

BIOMEDICINE

Antigen-Presenting Cells. (In Focus.) By Jonathan M. Austyn. 79 pp., illustrated. New York, IRL Press/Oxford University Press, 1989. $12.95.

The Assembly of the Nervous System. Edited by Lynn T. Landmesser. 313 pp., illustrated. New York. Alan ...

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO

The following courses will be offered: "OB/GYN and Abdominal Sonography: Update 1990" (San Francisco, March 16–18); "33rd Annual Diagnostic Radiology Postgraduate Course" (San Francisco, March 19–23); "Diagnostic ...

Breast Cancer and Estrogen Replacement (January 18, 1990; 322:201–4). Bruno de Lignieres of the Necker Hospital in Paris, France, should have been listed as the second author of the last letter on page 203. We regret the error.

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...