ALLOGENEIC bone marrow transplantation is increasingly used to treat hematologic neoplasias, disorders of marrow failure, and congenital deficiency diseases, and for many diseases is now the treatment of choice.^{1 , 2} Unfortunately, allogeneic ...

METASTASES to the brain occur in 20 to 30 percent of patients with systemic cancer¹ and are the most common type of intracranial tumor.^{2 , 3} The life expectancy of patients with brain metastases is short, and current treatment of such metastases is not ...

IT is not clear why diabetic nephropathy develops in approximately one third of patients with insulin-dependent diabetes mellitus (IDDM), usually during the second decade of their illness,^{1 , 2} but it has recently been suggested that this complication is ...

THE importance of Staphylococcus aureus as an etiologic agent of exit-site infection in continuous ambulatory peritoneal dialysis (CAPD) has been well established.^{1 2 3 4} Recent studies have shown that pericatheter infections are a major cause of the ...

THE replacement of malfunctioning tissues and organs has long been a clinical objective in medicine. Modern transplantation has been made possible by improved clinical care, a better understanding of immunogenetics, cross-matching of antibodies, and the ...

PROPAFENONE HYDROCHLORIDE (Rythmol) is an antiarrhythmic drug that has been extensively used in Europe and has recently been approved for oral use in the United States for the management of ventricular arrhythmias. The drug (2′-[3-(propylamino)-2-(hydroxy)...

OSTEOARTHRITIS is a clinically heterogeneous disease characterized by a progressive degeneration of the articular cartilages of both weight-bearing and non-weight-bearing joints.¹ Some forms of the disease are due to environmental or systemic events, such ...

Presentation of Case

A 45-year-old woman with known Hodgkin's disease was admitted to the hospital after the abrupt onset of "burning" dysesthesias.

She was well until six weeks earlier, when a nonproductive cough developed, with occasional subxiphoid ...

Cancer is a lethal disease because it metastasizes. Modern surgery and radiotherapy can control most primary tumors, but those that escape their local confines and spread to cause detectable visceral metastases are almost invariably fatal. As a result, ...

The relationship between the doctor and the nurse is a special one, based on mutual respect and interdependence, steeped in history, and stereotyped in popular culture. The underlying interaction can often be characterized as a game. In 1967 one of us ...

To the Editor: We applaud the courage and ingenuity of the members of the transplantation group at the University of Chicago as they begin their pioneering exploration of liver transplantation from living related donors. This innovative procedure ...

To the Editor: Alper and colleagues were able to define genetic markers for a low antibody response to hepatitis B vaccine (Sept. 14 issue).¹ Persons who had a low level of hepatitis B surface antibody (anti-HBs) after they had been vaccinated three ...

To the Editor: We have described a large family in which adult-onset seronegative spondylarthropathy was inherited as an autosomal dominant trait (April 6 issue).¹ The disease did not segregate with the HLA locus, and the HLA-B27 antigen, a known genetic ...

To the Editor: The data presented by Klein et al. (June 29 issue)* are very impressive in documenting a decrease in the rate of infection and longer intervals before nosocomial colonization in patients in the pediatric intensive care unit (ICU) in whom ...

To the Editor: I was recently asked to see a 10-year-old boy for suspected Tourette's syndrome because he had a head tremor and tilted his chin to the right. He had been brought to the clinic at the University of Utah by his father, who had divorced the ...

To the Editor: With regard to Oelkers' article (Aug. 24 issue),¹ we believe that a few issues need to be addressed. Patient 3 had taken diuretic agents, a well-known cause of hyponatremia² and the syndrome of inappropriate secretion of antidiuretic ...

To the Editor: Spinal cord impingement by metastatic carcinoma is a medical emergency. After this condition has been diagnosed, urgent therapeutic intervention (either radiotherapy or decompressive surgery) must be instituted to prevent the inevitable ...

To the Editor: As a clinical investigator whose work is supported in a major way by pharmaceutical companies, I have considered the possible conflicts of interest involved in a number of activities. Pharmaceutical companies have supported many of our ...

To the Editor: The recent Sounding Board article entitled "Fast-Food Fare" (Sept. 14 issue)* highlighted the nutritional inadequacy of most fast-food meals. A disturbing current trend is the incorporation of fast-food restaurants into children's ...

Like the previous editions of this book, the third edition is a multiauthor work divided into three sections. The first section contains two chapters written by the editor that introduce basic epidemiologic concepts and methods. The second section — the ...

This is an excellent textbook for its intended audience: junior hospital-staff physicians and senior medical students. The monograph is written from the perspective of a senior clinical microbiologist. Points about the suitability of specimens are well ...

This book covers an important and timely nephrologic topic: the effects of diabetes mellitus on the kidney. As the editors state in the preface, diabetic nephropathy is one of the leading diagnosed causes of end-stage renal disease, 20 percent of renal ...

The editors of this paperback textbook have oriented its level of presentation to general practitioners and to students and residents with an interest in respiratory diseases and critical care. The book's goal is to provide a more comprehensive discussion ...

"When I started writing about science in the early '60s," journalist Ronald Kotulak notes in Health Risks and the Press, "we science reporters tended to adopt a 'gee whiz' approach to science stories." Today, however, reporters and others are recognizing ...

This book, if taken with a grain of salt, is a useful introduction to the anthropologic history of disease. Cohen has done archeological research on the Neolithic Revolution — the dramatic changes in social life that occurred around the time of (but not ...

SOCIETY FOR ADOLESCENT MEDICINE

The annual meeting will take place in Atlanta, March 22–25.

Contact Soc. for Adolescent Med., Suite 101, 10727 White Oak Ave., Granada Hills, CA 91344; or call (818) 368–5996.

SCRIPPS CLINIC AND RESEARCH FOUNDATION

The ...

Canada's provincial health insurance plans have demonstrated an impressive capacity to operate successfully despite a basic policy conflict that says health care funding must be public and universal, physicians must retain their professional autonomy, ...