AUTOIMMUNE polyendocrinopathy—candidiasis—ectodermal dystrophy (APECED) is an autosomal recessive disease characterized by a variable combination of (1) failure of the parathyroid glands, adrenal cortex, gonads, pancreatic beta cells, gastric parietal ...

AMONG whites, the HLA-DR3 and HLA-DR4 alleles confer increased susceptibility to insulin-dependent diabetes mellitus (IDDM),^{1 2 3 4 5 6} but there is growing evidence that the alleles at the DQ rather than the DR locus are more intimately associated with ...

ALTHOUGH HLA haplotypes have been studied for more than 5000 diseases, only 3 diseases have been identified in which essentially all patients have the same HLA antigen: B27 in ankylosing spondylitis,^{1 , 2} DR4 in pemphigus vulgaris,³ and DR2 in narcolepsy.^...

PARANEOPLASTIC cerebellar degeneration is a rare remote effect of cancer characterized clinically by rapidly evolving pancerebellar symptoms (nystagmus, dysarthria, and appendicular and gait ataxia) and pathologically by widespread loss of cerebellar ...

THERE is considerable mortality and morbidity in the United States from perinatal group B streptococcal disease.^{1 , 2} Approximately 3 neonates per 1000 live births, or an estimated 11,000 infants annually, have invasive group B streptococcal disease; two ...

X-LINKED adrenoleukodystrophy is an inherited peroxisomal disease caused by a defective gene located within the Xq28 region of the X chromosome.¹ Childhood adrenoleukodystrophy is characterized by multifocal demyelination of the central nervous system and ...

THE hospital system of the Department of Veterans Affairs (VA), formerly the Veterans Administration, represents the principal way the government provides medical care directly to civilians. It does so in close collaboration with the nation's medical ...

Presentation of Case

A 68-year-old man was admitted to the hospital because of progressive abulia and a worsening right hemiparesis.

The patient was well until six weeks earlier, when he was noted to be mentally slow, with a shuffling gait and dysarthria; ...

The articles by Prochazka et al.¹ and Baisch et al.² in this issue of the Journal present information on associations of HLA alleles with disease. Prochazka et al. argue that it is one of the several linked loci of HLA that is most important in ...

A vigorous medical and political debate has begun again on euthanasia, a practice proscribed 2500 years ago in the Hippocratic oath.^{1 2 3 4} The issue has been publicized recently in three widely divergent settings: a journal article, a legislative ...

To the Editor: Our criticism of the paper by Platt et al. (Jan. 18 issue)¹ is based on four considerations: the statistical weakness of the data because of the small sample (alpha or Type I error²); inherent bias caused by overestimating the incidence of ...

To the Editor: Fahey et al. (Jan. 18 issue)¹ evaluated the usefulness of several serologic and cellular measures of immunity in predicting the onset of the acquired immunodeficiency syndrome (AIDS), using data on homosexual men infected with the human ...

To the Editor: An important question concerning transplantation is whether the subsequent survival and quality of life justify the procedure in HIV-infected patients. We reviewed or followed the course of five HIV-positive persons with hemophilia who ...

To the Editor: Although it is nearly four years since HIV type 2 (HIV-2) was first identified in West Africa,¹ there have been few confirmed reports of infection with this virus in the United States.² To date, most cases have been in West Africans. We ...

To the Editor: The letter by Shannon et al. (Oct. 5 issue)¹ on the use of penicillamine in children with small lead burdens forecasts dangerous changes in the approach to the management of childhood lead toxicity.

In 1985 the Centers for Disease Control (...

To the Editor: I agree with Dr. Beal that neoplastic processes are an important cause of multiple cranial neuropathy (Feb. 15 issue).¹ CT, magnetic resonance imaging, radionuclide scanning, and blood and spinal fluid studies are all important diagnostic ...

To the Editor: Arthritis is a well-recognized manifestation of Lyme disease.¹ The causative organism, Borrelia burgdorferi,^{2 , 3} is a tickborne spirochete that has been isolated from the synovial fluid of patients with Lyme arthritis.^{4 , 5} Synovial fluid ...

To the Editor: The chronic fibrosing process in some interstitial lung diseases is characterized by an increased number of activated fibroblasts and by an augmented deposition of collagen and other connective-tissue proteins, which impair normal lung ...

To the Editor: In connection with the Special Article by Smedira and others (Feb. 1 issue)* on the withholding and withdrawal of life support from the critically ill, your readers may be interested to know that at this time of many rapid changes in ...

It was a Saturday night,

Cool September breeze blowing

Calmly from the north,

All the stars reflecting

The lives they have seen falter

Just the way yours did, my friend.

No one believed your father's story,

The one about the gas pedal

Stuck to the ...

The initial impression of this work is that it is small, at least in relation to its title. On closer inspection it proves to be a compendium of selected aspects of a very large field. The editors are British, one a clinician and the other an ...

Surgical atlases have a special place in the surgeon's library. For students and residents, they are cookbooks, laying out in an orderly fashion the planning and execution of an operation. The illustrations bring clarity to the accompanying narrative and ...

This textbook on intestinal obstruction is massive, covering obstruction of the entire gastrointestinal tract and its diagnosis and treatment. There are numerous x-ray films and pictures of the many obstructive syndromes. I was struck by the descriptive ...

The rapid growth and development of vascular surgery as a specialty have been accompanied by the publication of textbooks and surgical atlases reflecting the current practice of vascular surgery. This book is unique, since it combines the advantages of a ...

This cross-disciplinary monograph has now been updated in a second edition, and it is even more comprehensive than before. Surgical treatments of cardiac dysrhythmias have been added to the cardiologic and anesthesiologic perspectives presented in the ...

Wolfe is a respected plastic surgeon, an early disciple of Tessier, the acknowledged father of craniofacial (orthomorphic) surgery. Berkowitz is an orthodontist. In this book they describe the principles and procedures that have evolved from their ...

For the surgical pathologist, this is both the best and worst of times. Advances in tumor therapy have underscored the importance of accurate diagnosis and classification. Tumor taxonomy remains the basis of cancer therapy, but at the same time the ...

AWARDS IN FACIAL PLASTIC SURGERY

Entries are now being accepted for the "1990 Journalism Awards of Excellence in Facial Plastic Surgery." Deadline for receipt is July 31.

Contact American Acad. of Facial Plastic and Reconstructive Surgery, 1110 Vermont ...