THERE can be many causes of anemia in patients with cancer. However, such patients are often anemic even before they receive cytotoxic therapy and even if their bone marrow is not involved by tumor.¹ The anemia of cancer is normochromic and normocytic, ...

IN patients with multiple myeloma, anemia is a common complication that has generally been considered to indicate a poor prognosis.¹ Although its frequency increases with the progression and duration of the disease,¹ it may occur in the absence of overt ...

THE importance of blood lipid levels as risk factors for coronary heart disease is well established.^{1 , 2} It is uncertain, however, whether their importance applies to men who already have signs and symptoms of cardiovascular disease. In such men, the ...

CUSHING'S syndrome may be caused by functioning tumors or hyperplasia of the adrenal cortex. It includes the various metabolic abnormalities induced by excessive secretion of glucocorticoid, principally of cortisol. Excess glucocorticoids suppress ...

SEVERE combined immunodeficiency (SCID) syndrome is caused by a group of genetic diseases characterized by abnormal function of T and B lymphocytes.¹ SCID was first described in children with lymphopenia, agammaglobulinemia, and absent proliferative ...

OCULOCUTANEOUS albinism is a group of severe genetic disorders of pigmentation characterized by reduced or absent biosynthesis of melanin pigment in the melanocytes of the skin, hair follicle, and eye.¹ Because of the striking phenotype, oculocutaneous ...

TWENTY-TWO years ago in the Journal, the term "multifocal atrial tachycardia" was first applied systematically to an arrhythmia characterized by irregularity, different forms of P waves, and (in adults) a rather grim prognosis.¹ In this article, I shall ...

Presentation of Case

A 53-year-old man was admitted to the hospital because of bilateral visual loss, weight loss, interstitial pulmonary disease, and hilar lymphadenopathy.

The patient was well until two years earlier, when hyperglycemia was discovered ...

Central to the normal immune response is the recognition of processed antigen by the cell-surface receptors of T lymphocytes. Within this interaction lies the capacity to discriminate appropriately between self and non-self antigens and to generate both ...

IN 1950 Glanzmann and Riniker described a new disease in two pairs of siblings and called it essentielle lymphocytophthise.¹ These infants died of an intractable illness characterized by diarrhea, candidiasis, lymphopenia, and a striking diminution of ...

Global strategies to control infectious disease have historically included the erection of barriers to international travel and immigration.^{1 2 3} Keeping people with infectious diseases outside national borders has reemerged as an important public health ...

To the Editor: The article by Swain et al. (Jan. 18 issue)¹ on the effect of oat bran on lipoprotein levels suffers from several fatal flaws. First, this study violates one of the principles of clinical trials: that the intervention should be of ...

To the Editor: Dr. Katz (Jan. 11 issue)¹ has made an admirable attempt at assembling some of the phenomena associated with overload heart failure. He has, however, neglected or obfuscated some issues that I believe are important in the pathophysiology of ...

To the Editor: In his editorial on the treatment of refractory ascites (Dec. 14 issue),¹ Epstein did not mention one of the most effective treatments of intractable ascites and the underlying disease that causes it — orthotopic liver transplantation. ...

To the Editor: Lyme disease, first described by Steere et al. in 1977,¹ was identified as a disease transmitted by the bite of ixodes ticks.² Burgdorfer, Barbour, and colleagues then isolated the infectious agent, a spirochete now known as Borrelia ...

To the Editor: In a pharmacokinetic study by Patchen et al. (Nov. 16 issue),¹ four of seven subjects given mefloquine base (13.5 to 15.4 mg per kilogram of body weight) experienced dizziness, and three also had vertigo. Indeed, analysis of registration ...

To the Editor: The article by Douglas (Feb. 15 issue)¹ states that amantadine is effective in treating influenza A if given within 48 hours of the onset of symptoms. This unqualified statement has often been misinterpreted and broadened to suggest that ...

To the Editor: The survival of infants delivered before the completion of the 26th week of gestation or weighing less than 500 g is well known, and there has been an increase in both survival of and quality of life for infants whose birth weight is more ...

This little book is a delightful addition to the library of any civilized physician. The author is an outstanding Swedish surgeon and a recognized authority on liver and gallbladder surgery. He presents us with a very gratifying synthesis of artistic ...

William Osler, in speaking of the Johns Hopkins Hospital, clearly indicates the importance of a book on this topic.

The opening of the Johns Hopkins Hospital in 1889 marked a new departure in medical education in the United States. It was not the hospital ...

A biography of Robert Graves is long overdue. He was certainly the leading physician of his day and a member of that extraordinary group that constituted the golden age of Irish medicine. Among the others were Stokes, Cheyne, Colles, Adams, and Corrigan, ...

The medical novel traces its ancestry back at least to Smollett's Humphrey Clinker (1770), but it did not take off as a genre until Sinclair Lewis's Arrowsmith (1925). Readers of popular fiction enjoy the drama of medicine, the depiction of pain and ...

The 1980s was a decade in which we faced and exposed some of our worst proclivities as a society. In our own form of glasnost, news items describing the abuse and pornographic exploitation of children, insider trading and greed on Wall Street, and the ...

COLBY COLLEGE

The following courses will be offered in Waterville, Me.: "Addiction Medicine" (July 8–11); "Child Abuse" (July 9 and 10); "Allergy, Asthma, and Dermatology: Clinical Pearls and Basic Mechanisms" (July 9–13); "Pediatrics" (July 9–13); "...