SEVERAL dideoxynucleoside analogues are potent inhibitors of the human immunodeficiency virus (HIV) in vitro.¹ One member of this class of compounds, 2′,3′-dideoxyinosine (ddI), is a purine nucleoside analogue that has in vitro activity against HIV in ...

CURRENTLY, the most promising agents for the treatment of the acquired immunodeficiency syndrome (AIDS) are chemotherapeutic drugs that inhibit the human immunodeficiency virus (HIV) by targeting the RNA-dependent DNA polymerase specific to the virus.^{1 2 ...}

EVIDENCE of extrahepatic synthesis of complement components by cells of the monocyte—macrophage series has been obtained in vitro.^{1 2 3 4 5 6} Enhanced local synthesis of complement components may also occur in vivo, in tissues invaded by macrophages and ...

HYPERTENSION is the most prevalent and most strongly predictive remediable risk factor for cardiovascular disease in older persons.¹ Although the control of blood pressure is readily achieved and reduces the risk of cardiac death and stroke,^{2 , 3} it is ...

IN many developing countries, diarrhea is the major cause of death in children one to five years of age.¹ This has remained true even in areas where oral rehydration therapy has been widely used.^{2 , 3} The lethal complications of diarrhea, other than ...

ON the basis of encouraging data from two studies in animals,^{1 , 2} the manufacturer of the antiretroviral nucleoside analogue zidovudine (formerly azido--thymidine [AZT]) has initiated a placebo-controlled trial to assess the chemoprophylactic efficacy of ...

OVER the past 10 years, interventional radiology has become an essential subspecialty of general radiology. It has evolved from providing purely diagnostic information (e.g., antegrade pyelography and percutaneous transhepatic cholangiography) to offering ...

Presentation of Case

A 12-year–old boy was admitted to the hospital because of increasing fatigue and intermittent fever of one month's duration.

The patient was a British citizen and had arrived in this country approximately two months earlier. He was in ...

Ever since the human immunodeficiency virus (HIV) was identified as the causative agent of the acquired immunodeficiency syndrome (AIDS), investigators have mounted an intensive effort to develop antiviral drugs with activity against HIV. In early 1987, ...

The heart has an inherent capacity to adjust its mass and shape in response to a sustained alteration in workload. Under conditions of heightened demand, myocytes add contractile units (to increase their diameter, length, or both) in a pattern that ...

Normal circulating glucose concentrations (euglycemia) are maintained by a number of control mechanisms that balance the rates at which glucose enters from the gastrointestinal tract, glycogenolysis, and gluconeogenesis with the rate of glucose use. ...

DEATHS

Ainsworth — Leonard B. Ainsworth, M.D., formerly of Lawrence, died on February 17 at the age of 83.

Dr. Ainsworth received his degree from Tufts College Medical School in 1931. He was a member of the American Medical Association and the ...

To the Editor: One of our house staff became infected with the human immunodeficiency virus (HIV) after a needle-stick injury 13 months ago. This episode was particularly difficult for all of us, and especially for the affected physician. What had been a ...

To the Editor: Dr. Johnson (Jan. 18 issue)* asserts that physicians would be trusted more if they were all salaried, yet he admits that "any salaried person... must be monitored for adherence to reasonable standards of performance." But surely physicians ...

To the Editor: The paper by Levine et al. (Dec. 21 issue)¹ demonstrating the efficacy of dexamethasone for the treatment of experimentally induced acute mountain sickness failed to note that we documented the value of dexamethasone for acute mountain ...

To the Editor: The study by Fujimura et al. (Dec. 21 issue)¹ is admirable and should help to discourage the current proliferation of unnecessary and often misleading electrophysiologic studies. There is, however, one flaw in the protocol that should be ...

To the Editor: The approach of Yandell et al. (Dec. 21 issue)¹ to identifying mutations of the retinoblastoma gene (RB-1) is of high technical quality. However, the discussion of the identification of RB-1 mutations and genetic counseling is misleading.

...

To the Editor: Krane et al. (Dec. 14 issue)¹ have provided a comprehensive review of the pathophysiology, diagnosis, and treatment of impotence. Common causes of male erectile failure are categorized according to evolving concepts of pathophysiology. We ...

To the Editor: In the November 3, 1988, issue of the Journal, Alarcon et al. reported on a familial defect in the surface expression of the T-cell receptor—CD3 complex leading to an impaired immune response in two siblings.¹ The biochemical studies ...

To the Editor: I wish to report a serious esophageal injury caused by a tortilla chip. A 63-year-old woman with no previous esophageal symptoms experienced retrosternal pain and odynophagia immediately after swallowing a corn tortilla chip. Minutes later ...

Water me no more

with glucose and saline,

I am pod not seed,

I will not bloom.

And puff me no more

with oxygen.

The monitor's beam

may dance on the screen

forever fed by

your green tanks and bottles,

your plastic tubes and pumps

mimicking order, but

I am ...

In his preface to this work the editor states forthrightly, "We have designed the Textbook to be encyclopedic, with a depth of coverage beyond that of other textbooks of medicine at this time." And encyclopedic it is, with 11 coeditors and 529 ...

It is a special treat to review a major new revision of a classic textbook. The original edition of this atlas appeared in 1955 and was last updated more than a decade ago, in 1979. This fourth, completely revised edition blends the traditional ...

In the study of infectious diseases, there are inevitably bandwagons. Information comes in surges with the discovery of new organisms and the development of new techniques to examine the old ones. With an organism that threatens to turn gastroenterology ...

Here, the editor brings together 14 authors long involved in the study or treatment of inflammatory bowel disease. These authors have written eloquent and succinct chapters that are well documented with extensive and up-to-date references. The new ...

The explosion of information in the field of medical microbiology presents medical students with an almost insurmountable task in gaining an in-depth appreciation of the subject. The demoralization of students is too apparent. For many there is time only ...

This massive book covers most areas in the expanding discipline of emergency medicine. There are excellent illustrations precisely depicting urgent and routine procedures. The drug index in the appendix is useful to the hurried emergency department ...

Public Health

Continuous Ambulatory Peritoneal Dialysis in the USA: Final report of the National CAPD Registry 1981–1988. Edited by Anne S. Lindblad, Joel W. Novak, and Karl D. Nolph. 303 pp. Boston, Kluwer Academic, 1989. $105.

The Health Benefits of ...

CALL FOR ABSTRACTS

Abstracts are now being accepted for the "2nd International Congress on Rate Adaptive Cardiac Pacing and Implantable Defibrillators: Hemodynamic, Clinical and Technical Implications," to be held in Munich, Federal Republic of Germany, ...

Thin Stage I Primary Cutaneous Malignant Melanoma: Comparison of Excision with Margins of 1 or 3 cm (May 5, 1988; 318:1159–62). On page 1160, in Table 1, the mean thickness for the total group should have been 1.009 mm, not 1.09 mm as printed. The same ...

Cyclosporine in Crohn's Disease (March 1, 1990; 322:636–7). On page 637, in the letter by Brynskov et al., the sentence beginning six lines from the top of the right-hand column should have read, "If the changes in the 22 patients who were prematurely ...