THE prognosis for children with non-Hodgkin's lymphoma has improved substantially in the past two decades. A key advance in treatment resulted from the recognition that the non-Hodgkin's lymphomas of childhood are systemic and have the potential for ...

TWO strategies are commonly used in the immunosuppressive treatment of patients with kidney allografts. The first consists of a combination of drugs, such as cyclosporine, steroids, and azathioprine, given immediately after surgery. The second consists of ...

PROSTAGLANDINS of the E and I series exhibit immunosuppressive effects.^{1 2 3 4 5} Two factors, however, have restricted the study in humans of the immunosuppressive potential of prostaglandins: the need to administer pharmacologic doses to animals to ...

IN the airway epithelium of patients with cystic fibrosis, the combination of excessive absorption of sodium^{1 , 2} and defective regulation of the secretory chloride channel of the apical membrane^{3 4 5 6} probably leads to the dehydration of airway ...

ADRENOCORTICAL carcinoma is a rare tumor^{1 , 2} with a poor prognosis.^{3 4 5 6} Its true incidence is unknown,⁷ but according to the Third National Cancer Survey of 1975⁸ the incidence is approximately 0.5 to 2 cases per million people per year, accounting ...

PREVIOUS estimates of the frequency with which illicit drugs and alcohol are used by pregnant women have relied on data collected in hospital-based populations before, at the time of, or after delivery.^{1 2 3} In addition, the majority of hospitals involved ...

COMPREHENSIVE functional assessment of elderly patients in clinical settings is becoming essential for optimal clinical management.¹ Frail elderly patients present with multiple interrelated problems, some of which often go undetected.² Comprehensive ...

Presentation of Case

A 16-year-old boy was admitted to the hospital because of painful swelling of the left leg.

He was well until two weeks earlier, when a sore throat developed. One week before admission he stayed out of school for one day because of a ...

The search for effective and safe methods of suppressing the immune response has been evolving over four decades. Progress has been marked by many disappointments and a few forward leaps. Clinical organ transplantation has served as the proving ground for ...

Life can now be sustained by medical technology under circumstances that just 15 to 20 years ago would have signified imminent death. This new power permits dramatic recoveries from some previously hopeless calamities. But, as with power in general, there ...

The highest courts in New York State and Missouri have made it more difficult to withhold life-sustaining treatment from incompetent patients. In the case of Mary O'Connor, the New York court ruled in October 1988 that such treatment must be given unless ...

To the Editor: In the Oct. 26 issue of the Journal,¹ Goedert et al. reported that the incidence of the acquired immunodeficiency syndrome (AIDS) in persons with hemophilia who were seropositive for the human immunodeficiency virus (HIV) was directly ...

To the Editor: There are important similarities between the biology, pathology, and clinical stages of Lyme disease and those of syphilis.^{1 2 3 4 5 6 7} Both diseases are caused by spirochetes; the Borrelia burg-dorferi that causes Lyme disease and the ...

To the Editor: The conclusion of Lange et al. (Dec. 7 issue)¹ from their study of cocaine-induced coronary-artery constriction implies that they know the shape of the cocaine dose–response curve for cardiac effects. They used doses of 110 to 210 mg ...

To the Editor: Alpha₁-adrenoceptor—blocking agents (alpha1-blockers) are receiving increasing attention in the treatment of hypertension.^{1 , 2} Nevertheless, the first-dose hypotension caused by alpha1-blockers still appears to be troublesome in some ...

To the Editor: Dr. Barnes' excellent article, "A New Approach to the Treatment of Asthma" (Nov. 30 issue),¹ describes treatments that have been used successfully for years, even if the pathophysio logic reason for their success has only recently been ...

To the Editor: It is extremely rare for a pleural effusion to occur as the result of aspiration.

A three-year-old boy was admitted to a local hospital's emergency room with a temperature of 40°C, dyspnea, and severe cough. Chest radiography revealed an ...

To the Editor: Levey and Hill (Dec. 21 issue)* explain to us that "to expect political and medical leaders to seize the day with legislative action that breaks the pattern of irresolution is to imagine that we are living in heroic times." Elegant as this ...

Living here is being disembodied...

Septuagenarians... octogenarians...

Frail wraiths wander about,

clinging to air.

Sometimes a spirit just floats away,

remembered reluctantly.

We don't wish to be reminded

of mortality.

Even the freight elevator

is ...

Norman Cousins' new book continues the story of the "obsession" he first reported in Anatomy of an Illness (New York: W.W. Norton, 1979): to demonstrate that emotion and mood affect biology directly. Cousins has set out to influence physicians, ...

With the resurgence of discussions about national health insurance, there has been increased interest in the design of health systems in other countries. Much of the comparative literature in this area has focused on a limited number of countries, ...

In anticipation of the centennial of the University of Minnesota Medical School in 1988, Professor Wilson began his studies on the history of the beginnings, development, and special problems of the school some years ago. The cumulation of his detailed ...

Here is book by two native sons of a small New England city that would be ideal for the library of a community hospital of about 100 beds. It would serve well as a reference for members of the medical staff, the trustees, the administration, and the ...

This informative book consists primarily of papers from symposiums sponsored by the University of Mississippi's Center for the Study of Southern Culture.

Part I deals with science in the Old South and includes such topics as science in the antebellum ...

Here, in an elegant and handsomely illustrated small volume, the author, a pharmacologist and medical historian, has undertaken to describe the leading characteristics of ancient Egyptian medicine for both medical and nonmedical readers. As might be ...

Biomedical Science

Atrial Natriuretic Peptides. (Contemporary Issues in Nephrology. Vol. 21.) Edited by Barry M. Brenner and Jay H. Stein. 276 pp., illustrated. New York, Churchill Livingstone, 1989. $79.

The Atrium in Health and Disease. (Cardiostim ...

TOPICS IN INTERNAL MEDICINE

The course will be offered in Burlington, Mass., May 3–5.

Contact Donna Ales, Educational Seminars, Lahey Clinic Medical Ctr., 41 Mall Rd., Burlington, MA 01804; or call (617) 273–5238.

BACK PAIN

The spring symposium will be ...

The federal government, persuaded by the results of a massive study and the argument of organized medicine that primary care physicians should be better compensated for the services they deliver, has enacted legislation moving Medicare toward better ...