IN the first clearly traced link between exposure to a carcinogen (tar pitch) and the development of cancer, Percival Pott in 1775 described the occurrence of squamous-cell cancer of the scrotum in chimney sweeps.¹ Although these cancers of the male ...

THE myopathies associated with infection with the human immunodeficiency virus type 1 (HIV) are a histologically heterogeneous group of disorders that include inflammatory myopathy identical to polymyositis,^{1 2 3 4 5} noninflammatory destructive myopathy ...

MANY patients with cancer have hypercalcemia because their tumor produces a humoral factor that interacts with parathyroid hormone receptors.^{1 2 3 4 5} A novel parathyroid hormone-related protein (PTHRP) has been isolated recently from tumors associated ...

IVERMECTIN is a semisynthetic macrolide antibiotic whose recent availability has entirely transformed strategies for the treatment and control of the filarial disease onchocerciasis, a major cause of blindness. Ivermectin destroys onchocerca micro-...

FIRST described by Bouroncle et al. in 1958 as leukemic reticuloendotheliosis,¹ hairy-cell leukemia is now recognized to be a low-grade B-cell neoplasm.² If untreated, this disorder follows a chronic, inexorable course, usually characterized by ...

THERE is evidence that the adoption of a prospective payment system based on diagnosis-related groups (DRGs) has enabled Medicare to restrain the growth in its payments to hospitals. In addition to the federal government, third-party payers in nearly a ...

IN recent years, there have been important advances in our understanding of the biology of bladder cancer. They have been achieved with the use of new experimental models, the study of oncogenes in bladder cancer, and the demonstration of a wide range of ...

Presentation of Case

A 57-year-old woman was admitted to the hospital because of headache, somnolence, increasing right hemiparesis, and a ring-enhancing lesion in the left thalamus.

The patient was in a stable state of health until four days earlier, ...

Human diseases have been treated with the sun's rays since antiquity.¹ It is a form of phototherapy, which is defined as the direct use of nonionizing radiation to treat disease. The use of ultraviolet B radiation (290 to 320 nm) in the treatment of ...

The proposal that hypercalcemia of cancer is caused by the ectopic secretion of a parathyroid hormone-like substance has been a riveting hypothesis for the past 50 years.¹ We now know that certain solid tumors do synthesize and secrete a polypeptide that ...

Lymphatic filariasis due to infection with Wuchereria bancrofti was introduced into the Americas with the importation of infected African slaves. In the early 1900s, both asymptomatic microfilaremia and the most obvious stigma of lymphatic filariasis, ...

To the Editor: Dr. Aoun's article (Sept. 7 issue)* addressed a secret fear we practicing physicians all share and have so far either refused to believe in or denied. Perhaps the older generation among us remembers working with sick patients whose ...

To the Editor: Parathyroid hormone-related protein (PTHRP) is a recently characterized 141-amino acid peptide that is responsible for the humoral hypercalcemia of cancer.¹ We previously reported on a patient with massive mammary hyperplasia occurring ...

To the Editor: Goodnough and colleagues (Oct. 26 issue)¹ demonstrate that recombinant human erythropoietin increases the number of red cells that may be obtained when 4 or more units of blood are collected within a 21-day period. Because red cells ...

To the Editor: A 64-year-old man was admitted to our hospital in October 1989 with pancytopenia and slight splenomegaly. In 1979 a hemolytic crisis had occurred after the consumption of fava beans, which led to the diagnosis of a glucose-6-phosphate ...

To the Editor: In comparing two groups of patients with morning serum lithium levels in two different ranges, it appears that Gelenberg et al. (Nov. 30 issue)¹ did not account for variations among patients in dose scheduling. Were all patients taking ...

To the Editor: Case 34–1989 (Aug. 24 issue), though excellent, contains a subtle but important error of identification. The legend to Figure 5 describes the granular layer of the cerebellar cortex (noted as pink in color) as superficial to the molecular ...

To the Editor: Reading the Sounding Board article by Welch (Nov. 2 issue),* I was struck by his comment that the standard benefit package as described by the Health Policy Agenda might be the type of policy providers would write. On the contrary, I think ...

To the Editor: In private life, physicians are occasionally called on to attend to the critical needs of another person. However, a recent experience of a type that many of us will undoubtedly encounter brings to attention a serious problem.

At a wedding ...

Tension between health policy and medical practice exists in many situations. For example, regional variations in practice patterns persist despite extensive shared information,^{1 2 3} there are substantial deviations from accepted guidelines daily in the ...

Unlike many books reviewed here, this work is not intended primarily for physicians. Instead, it is designed for graduate or advanced undergraduate students in genetics and is a carefully constructed textbook structured for a term course in this field. ...

Research in human sexuality has evolved. First there were case-history reports, then population surveys such as those of Kinsey, and then investigations of sexual physiology such as those of Masters and Johnson. Now there is an increasing emphasis on ...

Advances in our understanding of perinatal biology and disease continue to improve the treatment of the fetus and newborn —advances that frequently involve contributions from investigators in many fields. Here, the editors seek to create a niche for a ...

A formidable array of bioscientists has been assembled for this second edition of a monograph first published 11 years ago. Only 7 of the 23 authors are obstetricians and gynecologists; some have credentials in anatomy, physiology, biochemistry, pathology,...

This is a classic. I read this book as a medical student and resident; reading the newest edition was a pleasure. It has been updated and thoroughly revised. The authors are thoughtful clinicians and true scholars who have devoted their careers to the ...

"By their fruits ye shall know them" (St. Matthew).

Every chapter in this practical new textbook of obstetrics and gynecology begins with a quotation from Sir William Osler. The quotation from St. Matthew is an appropriate one to describe the book and its ...

DRUG INFORMATION ASSOCIATION

The following workshops will be held: "The Integrated Safety Summary: Scientific and Regulatory Aspects" (Bethesda, Md., April 25–27); "Statistical Methodology in Clinical Research and Development" (Vienna, Austria, May 7–9); ...