APPROXIMATELY 20,000 new epithelial ovarian cancers are reported annually in the United States, and about 30 percent of these are apparently localized (Stages I and II according to the classification of the International Federation of Gynecology and ...

RECENT studies have shown that erythromycin mimics the effect of the gastrointestinal polypeptide motilin on gastrointestinal motility.^{1 , 2} Erythromycin and related 14-member macrolide compounds inhibit the binding of motilin to its receptors on ...

POLYNEUROPATHY affecting the somatic and autonomie nervous systems is a common complication of diabetes mellitus. Although many attempts have been made to halt or reverse diabetic neuropathy by improved metabolic control, the use of pharmacologic agents, ...

THE finding that 5-azacytidine selectively increases the production of fetal hemoglobin in primates¹ led to clinical trials in which increases in fetal-hemoglobin levels were demonstrated in patients with beta-thalassemia² and with sickle cell disease.^{3 ,} ...

LONG-TERM follow-up studies of survival show that in most cases, primary breast cancer is a systemic disease that may recur decades after it has been initially diagnosed.¹ However, findings from studies of the survival of patients with this disorder ...

OBESITY is a complex condition characterized by disordered regulation of the energy balance.¹ Although much research has focused on the behavioral, metabolic, and genetic aspects of obesity, the regulation of lipid deposition into adipose tissue is still ...

SEVERE combined immunodeficiency (SCID) is a syndrome that includes a spectrum of X-linked and autosomal genetic defects affecting both cellular and humoral immunity.¹ Affected persons have severe and persistent infections in infancy, leading to failure ...

PREVIOUS investigations have examined the responses of physicians to monetary incentives.^{1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19} However, only a few of these studies have focused on ambulatory care,^{8 9 10 11 12 13 14 15 16 17 18 19} fewer still ...

Presentation of Case

A 78-year-old woman was admitted to the hospital because of diarrhea of eight years' duration.

The patient was in excellent health until eight years earlier, when she experienced the onset of crampy abdominal pain and loose stools, ...

Of all the lesions of the female genital tract, ovarian cancer represents the most difficult challenge. It has the highest fatality-to-case ratio of the gynecologic cancers, with more than 20,000 new cases and 12,000 deaths from ovarian cancer expected in ...

Diabetes commonly causes widespread damage to the peripheral nervous system, involving chiefly the somatic sensory and autonomic nervous systems, although in individual patients the involvement of one system or the other may predominate. Small nerve ...

Since the early 1970s, second-look surgery has played a central part in studies of chemotherapy and radiation treatment for ovarian cancer of an advanced stage. Although the operation has been used extensively to evaluate the benefit of other types of ...

To the Editor: Although the Journal's policy on the publication of negative results (Aug. 17 issue)¹ is laudable, I cannot agree with Dr. Angell's assessment that the chosen example of a negative study² was "carefully designed and analyzed." At least ...

To the Editor: As Angell notes,¹ a study that is well designed and conducted makes a positive contribution to biomedical knowledge; thus, it seems wrong to call it a "negative study." Others have requested that similar terms not be used,² I believe with ...

To the Editor: Correction of the hemorrhagic tendency and improved surgical hemostasis in mild hemophilia and von Willebrand's disease are acknowledged actions of desmopressin acetate (1-desamino-8-D-arginine vasopressin), but its effect in acquired ...

To the Editor: Allred et al. (Nov. 23 issue)¹ have concluded that "low levels of carboxyhemoglobin exacerbate myocardial ischemia during graded exercise in subjects with coronary artery disease." Without appropriate clarification, that conclusion is ...

To the Editor: Palardy et al. (Nov. 23 issue)¹ did not find a significant correlation between symptoms of hypoglycemia and levels of blood glucose in patients with suspected postprandial hypoglycemia. However, symptoms of hypoglycemia (such as weakness, ...

To the Editor: The two studies on Graves' ophthalmopathy reported in the November 16 issue^{1 , 2} are seriously flawed. In neither study was there any indication that biostatistical principles were used to determine the number of patients to be studied. ...

To the Editor: The acquired immunodeficiency syndrome (AIDS), or end-stage infection with the human immunodeficiency virus (HIV), is generally associated with substantial weight loss. We have, however, observed some patients in whom the knowledge of HIV ...

An old woman slid out of her chair

Like Icarus falling from the sky:

Everyone and no one noticed

How her vertebrae, melted by

The fever of age, ran like water

Over the seat's edge

And gathered her body upon itself,

A pool, a soft splash

And an IV dripping ...

As a result of the marked reduction in curricular time dedicated to anatomy and other basic-science courses in the 1970s, so-called "core textbooks" have been produced in sufficient numbers that most publishers of textbooks of basic medical science have ...

Here is an abbreviated treatment of human gross anatomy, designed to introduce the student to the broad topic of gross anatomy, correlated with functional and clinical material, without, as stated in the preface, "attention to minute details." The book ...

These authors are to be congratulated for accomplishing the goal set forth in the preface to the third edition of Functional Histology: presenting a readable book that does not overload the student faced with today's full curriculum. The information in ...

This is a welcome fourth edition of a highly respected microbiology textbook; the previous edition was published 10 years ago. It is actually four books in one: bacterial physiology and genetics by Davis, immunology by Eisen, a multiauthored section on ...

The natural immune system produces our innate immune responsiveness in the absence of previous sensitization. Originally, this system was recognized as the resistance to infectious disease mediated by natural effector cells such as granulocytes and ...

Only to immunologists has the Nobel Prize been given for fanciful theories rather than seminal discoveries. No other group of biomedical scientists is as concerned with the epistemology of their discipline as are immunologists. The conundrums posed by the ...

Like previous editions, this edition is based on the attractive premise that clinical acid–base and electrolyte disorders are best understood in the context of basic physiology. To this end, the book is divided into two large sections.

The first is a ...

AMERICAN COLLEGE OF PHYSICIANS

The 71st annual session will take place in Chicago, April 26–29.

Contact ACP, Independence Mall W., 6th St. at Race, Philadelphia, PA 19106–1572; or call (800) 523–1546, ext. 2429 (natl.) or (215) 351–2429 (Pa.).

PACIFIC ...