INFECTION with the human immunodeficiency virus (HIV) causes chronic, progressive depletion of CD4+ helper/inducer T lymphocytes (CD4+ cells).^{1 2 3 4} Together with the infection of macrophages and other cells, this depletion creates an immune deficiency ...

A RELIABLE blood test indicating the presence or absence of malignant disease has not yet been devised, although tumor markers with reasonable sensitivity and specificity are known for some cancers. It is essential that a useful tumor marker discriminate ...

THE concept that water-suppressed proton nuclear magnetic resonance (NMR) spectroscopy of blood plasma could be used to detect the presence of malignant tumors has been controversial. Fossel et al.^{1 2 3 4 5} measured the average line widths of the methyl ...

INTERLEUKIN-2 is a 15,000-dalton protein that is produced and secreted by activated T lymphocytes and has profound effects on the immune response.^{1 , 2} One of these effects is the induction of lymphokine-activated killer cells that are able to lyse a ...

FIRST described as a human pathogen 50 years ago,¹ Yersinia enterocolitica has become a major cause of diarrhea in much of the industrialized world. In Scandinavia, Japan, Canada, and parts of Europe, the isolation rates of Y. enterocolitica from patients ...

ACROMEGALY, well described in antiquity, was recognized as a distinct clinical syndrome by Marie in 1886.¹ The pituitary source of the disorder was confirmed in 1909 by Cushing, who postulated the excessive secretion of growth-promoting hormone by a ...

IT is estimated that 5000 patients with diabetes in the United States and 30,000 to 40,000 worldwide become blind each year from retinopathy. Despite advances in the use of photocoagulation and vitrectomy, diabetic retinopathy has been the leading cause ...

Presentation of Case

A 76-year-old man was admitted to the hospital because of coronary artery disease and staphylococcal sepsis.

The patient was well until four years earlier, when he consulted a physician because of "burning" anterior chest pain on ...

Serologic testing for the human immunodeficiency virus (HIV) has shown that millions of persons are infected worldwide. What proportion of these will have progression to symptomatic and indeed fatal disease, and at what rate, are critical questions.

...

Nuclear magnetic resonance (NMR) has been used in basic research by physicists, chemists, and biochemists since its invention in 1946. In the past decade it has been applied in medicine, particularly with the development of magnetic resonance imaging, ...

Beginning with this issue, we have changed the arrangement of our articles and some of the headings used to classify them. We have dropped the Medical Intelligence section, grouped all review articles under a new heading, and introduced another new ...

To the Editor: In the July 6 issue, Thaler et al. present two fascinating cases of catastrophic transfusion-associated graft-versus-host disease occurring after open-heart surgery.¹ However, I must disagree with their assertion that "cardiac surgery in ...

To the Editor: Prompted largely by recent reports from Europe,^{1 2 3} questions have been raised about the safety of human insulin as compared with nonhuman insulin. The contention is that human (more than bovine or porcine) insulin may cause hypoglycemic ...

To the Editor: The age distribution, according to type of diabetes, of end-stage renal disease in Michigan reported by Cowie et al. (Oct. 19 issue)¹ sheds light on problems with the classification of diabetes as juvenile or adult-onset in preliminary ...

To the Editor: Showstack and colleagues (Oct. 19 issue)* have presented interesting data on the relation between the use of cyclosporine and resource consumption. There can be little doubt that cyclosporine has a beneficial effect on such outcomes as ...

To the Editor: We would like to offer some further comments about the safety of consuming sushi (Sept. 28 issue).^{1 2 3 4} The Food and Drug Administration has issued an advisory⁵ to state and local regulatory agencies recommending that fish served raw, ...

To the Editor: Dr. Healy (April 20, 1989, issue)¹ has made a provocative suggestion that industry should pay a "talent tax" on "all industry—university agreements," to be used "exclusively for the education and nurturing of the young." This was in ...

To the Editor: As another generation of medical students and house officers comes to interview for internships and fellowships, I am reminded of buying olives. One cannot purchase even the most modest olive without becoming aware of marketing ploys ...

To the Editor: I am writing to describe a new clinical entity recently identified in an asymptomatic man undergoing routine surveillance colonoscopy after the resection of a colon carcinoma. He gave no recent history of hematochezia or melena. For ...

The literature on physicians' refusal of patients' demands is sparse. Siegler,¹ Brett and McCullough,² and Leikin³ have reported on relatively uncontroversial issues in primary care, such as the denial of antibiotics for viral infections or the refusal of ...

Here is a collection of papers covering a wide variety of issues in transplantation policy. The topics include the role of government, the economics and ethics of markets for human organs, the ethical criteria for procuring and distributing organs, the ...

This book considers all aspects of lower-extremity amputation, beginning with the management of acute and chronic ischemia and continuing with a discussion of newer developments, prosthetics, and the psychological aspects of amputation. A minor defect is ...

This publication, now in its fourth edition, is 1 of 18 volumes in a series entitled Operative Surgery encompassing all surgical specialties. The scope of this book is restricted to operative techniques and indications, complications, and results. Some ...

This second edition is a general textbook that covers the expanding field of pediatric neurosurgery. It is divided into seven parts: developmental anomalies, hydrocephalus, trauma, neoplasms, infections, vascular diseases, and other diseases. The major ...

At a length of 575 pages, this textbook of medicine is considerably more approachable than either Harrison's Principles of Internal Medicine (11th ed. New York: McGraw-Hill, 1987; 2080 pages) or Cecil Textbook of Medicine (18th ed. Philadelphia: W.B. ...

Introductory textbooks for the medical and surgical specialties have flourished to such an extent that they describe every conceivable aspect of specialty training. General Ophthalmology is a traditional introductory-level book written in a concise, ...

This is the fifth edition of a work that for most residents and practitioners has become the most frequently cited reference on cataract surgery. The previous editions were issued in 1972, 1976, 1981, and 1984. The new edition is written by Dr. Norman ...

Medicine

The Adrenal and Hypertension: From cloning to clinic. (Serono Symposia Publications. Vol. 57.) Edited by F. Mantero, R. Takeda, B.A. Scoggins, E.G. Biglieri, and J.W. Funder. 480 pp., illustrated. New York, Raven Press, 1989. $88.

Antiviral ...

CALL FOR ABSTRACTS

Abstracts are now being accepted for the "International Symposium on Advances in Neuro-Oncology," to be held in Sanremo, Italy, Sept. 26–29. Deadline for receipt is May 31.

Contact Fondazione Giovanni Lorenzini, Via Monte Napoleone 23, ...

Short-Term Effects of Carbon Monoxide Exposure on the Exercise Performance of Subjects with Coronary Artery Disease (November 23, 1989; 321:1426–32). On page 1429, in Table 2, under the column heading "Time to Angina (sec)," the first value, for room air (...

Inhibition of Glucose Transport into Rat Islet Cells by Immunoglobulins from Patients with New-Onset Insulin-Dependent Diabetes Mellitus (March 8, 1990; 322:653–9). On page 655, the legend for Figure 2 should have read, "Effects of IgG Fractions from ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the june 1982 issue of the Annals of ...