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March 22, 1990  Vol. 322 No. 12

Original Articles
789-794
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DURING the first half of this century, numerous claims of pathologic findings in the brains of patients with schizophrenia were reported, but most of these findings turned out to be artifacts, the results of poorly controlled studies, or impossible to ...

795-801

IN 1951 Ehrström1 noted that "arterial hypertension of the malignant type has never been diagnosed in North Greenland and essential hypertension is rare." The results of more recent studies of blood pressure in Eskimo populations are conflicting.2 3 4 5 ...

802-809

THE ideal therapy for osteoporosis should increase bone mass to a level sufficient to decrease the occurrence of new fractures. However, the treatments commonly used, such as calcium, estrogen, and calcitonin, act by decreasing bone resorption and thus ...

810-816
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NAUSEA and vomiting are common side effects of antimetabolites and cytotoxic drugs.1 Cisplatin (cis-dichloro-diammineplatinum II), an agent highly effective against a variety of cancers (including testicular, ovarian, urinary-bladder, and head and neck ...

816-821

ALL patients vomit during the 24 hours after the administration of high doses of cisplatin unless given antiemetic agents,1 and none of the currently available antiemetic regimens are entirely effective. Metoclopramide has been considered the most ...

Special Article
821-825
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DURING the 1974–1975 academic year, 500 unselected college women who consulted gynecologists at a student health service were studied in order to relate sexual practices to the prevalence of sexually transmitted pathogens.1 2 3 4 Each participant ...

Medical Intelligence
825-829

SEISMIC catastrophes leave in their wake survivors trapped under the rubble who suffer from extensive muscle damage and its devastating sequelae of hemodynamic and metabolic disturbances and acute renal failure.1 We review here the pathogenesis of shock ...

Case Records of the Massachusetts General Hospital
829-841

Presentation of Case

A 21-year-old man was admitted to the hospital because of chronic nausea, vomiting, diarrhea, progressive weakness, and suspected polyneuropathy.

The patient was well until the age of 14 years, when he experienced the sudden onset of ...

Editorials
842-845

Schizophrenia is a devastating disease of unknown cause. Its protean symptoms range from a pervasive blunting of affect, thought, and socialization, to florid hallucinations and delusions. Its characteristic onset during adolescence and young adulthood ...

845-846

Postmenopausal osteoporosis is a major public health problem, whose impact is expected to reach epidemic proportions during the early part of the next century as the population ages. Consequently, whereas the prevention of bone loss will probably remain ...

846-848

Cancer chemotherapy is a double-edged sword. Dramatic responses may be accompanied by equally dramatic toxic effects, the most feared of which are nausea and vomiting.1 The public's perception is that severe nausea and vomiting are inevitable with the use ...

Massachusetts Medical Society
848-849

DEATHS

Auerbach — Henry Auerbach, M.D., of Attleboro, died on January 23 at the age of 72.

Dr. Auerbach received his degree from Tufts College Medical School in 1950. He was a member of the American Medical Association and the American Academy of General ...

Correspondence
849-850

To the Editor: In some persons, the long-term ingestion of licorice, which contains glycoside derivatives of glycyrrhetinic acid, produces symptoms similar to those of mineralocorticoid excess —namely, hypertension, sodium retention, and hypokalemia.1 , ...

850-851

To the Editor: The data of Cumming and colleagues (Oct. 5 issue)* do not reflect blood donations in the metropolitan areas of New York City, San Francisco, Houston, or Miami, although this is not stated in their report. To what extent does the absence of ...

851-853

To the Editor: Transplantation is increasingly available for elderly patients with kidney failure.1 Likewise, there is a trend toward increasing use of organs taken from older donors (i.e., over 50 years of age).2 This is occurring despite evidence of ...

853

To the Editor: Witherspoon et al. (Sept. 21 issue)1 analyzed the incidence of secondary cancers after bone marrow transplantation. Although they discuss the role of immunosuppression in the pathogenesis of secondary cancers, they provide no information ...

853-854

To the Editor: Bale and coworkers reported in the May 25 issue1 that they had localized the gene for hereditary cutaneous malignant melanoma—dysplastic nevus (dysplastic nevus syndrome) to the distal part of the short arm of chromosome 1 (1p36) in a ...

854-855

To the Editor: The article by Amselem et al. (Oct. 12 issue) 1 shows linkage in two families between Laron dwarfism and the growth hormone—receptor gene. DNA-sequence analysis of growth hormone—receptor complementary DNA revealed a single-base ...

855

To the Editor: In June 1986, a previously healthy 44-year-old male Yupik Eskimo was hospitalized with diplopia, dry mouth, shortness of breath, dysarthria, dysphagia, blurred vision, generalized weakness, and dilated nonreactive pupils. The symptoms ...

855-856

To the Editor: We report the successful application of electrohydraulic lithrotripsy to an impacted calcified fecalith, which we believe is a novel and effective treatment for this problem. A 76-year-old woman was referred for an asymptomatic pelvic ...

856

To the Editor: I am a 59-year-old male clinical psychologist who recently underwent magnetic resonance imaging (MRI) of the brain, with and without enhancement. My knowledge of MRI procedures was that of a well-educated layperson — i.e., I knew what MRI ...

856

To the Editor: In his Sounding Board article (Oct. 5 issue),* Dr. Arias seems to think that the complexity of medical science has made it impossible to be a complete physician-scientist and suggests that basic scientists should now be the ones to bridge ...

857
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We wish there was only one way to fail,

a hapless babe or two

lacking the know-how

to drink, breathe, and swallow

at the same time.

Instead of this progeny of souls

who received no love,

so can give none;

legions of near-retarded moms on welfare

with a ...

Book Reviews
857

This is an atlas of cross-sectional anatomical drawings with correlative x-ray computed tomography (CT) and magnetic resonance imaging (MRI) scans. The anatomical drawings were prepared by Wetzel, starting in the 1930s at the Institute of Anatomy in ...

857

This is the second edition of a major work. The authors note that important advances in computerized imaging, ultrasound, digital angiography, magnetic resonance imaging, and computed tomography have occurred since the previous edition was published in ...

858

Pediatric radiology differs from other areas of radiology in that it is not oriented to a single organ system or a specific technology. It includes almost all fields in radiology, the common factor being the age of the patient. Because of this and the ...

858

The hallmark of this and other radiology textbooks by Eisenberg is practicality. The busy radiologist confronting an unfamiliar or unusual radiographic pattern is the intended audience for this eminently practical text—atlas.

In place of the traditional ...

858-859

Our first book here (Kopans) is a welcome update in the field of breast imaging. Its organization has a natural flow, beginning with a discussion of the causation of breast cancer, the efficacy of screening, and the basic principles of mammography, ...

Books Received
859-860

Nursing

Classification of Nursing Diagnoses. Edited by Rose Mary Carroll-Johnson. 584 pp., illustrated. Philadelphia, J.B. Lippincott, 1989. $35.95.

Introduction to Nursing: Concepts, Issues, and opportunities. By Janice B. Lindberg, Mary Love Hunter, and ...

Notices
860-863

AMERICAN COLLEGE OF GASTROENTEROLOGY

The regional postgraduate course will be offered in Tarrytown, N.Y., on April 7. Also, the "Annual Postgraduate Course and Scientific Meeting" will be held in San Francisco, Oct. 27–31.

Contact ACG, 4222 King St., ...

Correction
863
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Immunization of Six-Month-Old Infants with Different Doses of Edmonston–Zagreb and Schwarz Measles Vaccines (March 1, 1990; 322:580–7). On page 583, in Table 2, the fourth and sixth values in the first column of P values and the sixth value in the second ...

Special Report
863-868
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Patients with atrial fibrillation unrelated to rheumatic or prosthetic valvular heart disease have a risk of ischemic stroke about five times higher than that of persons with normal sinus rhythm.1 , 2 Atrial fibrillation occurring in the absence of ...

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