IT has been clearly demonstrated that patients who have received chemotherapy with alkylating agents for ovarian cancer have an increased risk of acute leukemia, particularly the myeloid type.^{1 2 3 4 5 6} Although the drugs treosulfan, melphalan, ...

A NUMBER of studies have demonstrated that survivors of Hodgkin's disease who received chemotherapy with alkylating agents are at risk for the development of acute leukemia, particularly the myeloid type, within 10 years of treatment.^{1 2 3 4 5 6 7 8 9 10 ...}

THE most common cause of Addison's disease (primary adrenal failure) is autoimmune adrenal disease. In adults, metastatic tumors, amyloidosis, and tuberculosis and other infectious processes account for most of the remaining cases. In children, ...

VISCERAL leishmaniasis is caused by obligate intracellular protozoa of the genus leishmania. The disease is worldwide in distribution and occurs in parts of Africa, North and South America, eastern and southern Europe, and Asia.^{1 2 3} Visceral ...

THE rising demand for geriatric and long-term care in the United States as a result of increases in the elderly population^{1 , 2} may be straining our already overtaxed and fragmented long-term care delivery system. Anecdotal evidence suggests that recent ...

METACHROMATIC leukodystrophy of the late infantile type, an autosomal recessive inherited disorder caused by a deficiency of arylsulfatase A activity, is characterized by progressive mental regression, loss of speech, quadriparesis, peripheral neuropathy, ...

FIBRINOLYTIC therapy is a major advance in the treatment of occlusive vascular disease. Problems remain, however, including resistance to fibrinolytic therapy, delays in reperfusion, reocclusion after successful thrombolysis, and serious hemorrhage.^{1 2 3} ...

Presentation of Case

A 29-year-old man was admitted to the hospital for the fourth time because of an increasing cough and fever.

There was a 10-year history of bisexual activity, with treatment in the past for primary syphilis, gonorrhea, and oral ...

The majority of the published studies addressing the question of treatment-related leukemia used cohort methods of analysis in which the incidence of leukemia was measured among patients treated for primary cancer. Comparisons of the risk of leukemia have ...

The leukodystrophies are a group of genetically transmitted diseases in which abnormal metabolism of myelin constituents leads to progressive demyelination. Even though none of these disorders are common, the physician confronted by a child or an adult ...

This issue of the Journal includes a report on the benefits of adding interferon gamma to pentavalent antimony in the treatment of refractory or severe visceral leishmaniasis.¹ In order to evaluate this new, sophisticated therapy for an old parasitic ...

To the Editor: Hepatitis B virus infection has been associated with acupuncture.¹ We report an outbreak of hepatitis B, probably due to finger pricks for estimations of glucose levels, in a hospital community. Between January 1986 and May 1988, 18 ...

To the Editor: Miller and his colleagues (July 13 issue)¹ report on the use of quinidine and exchange transfusion for the treatment of severe malaria in the United States. Although they did not conduct a randomized, prospective study of the use of ...

To the Editor: Masson and coworkers (July 13 issue)¹ report an elegant study in which pulmonary microvascular cytology provided presumptive evidence of lymphangitic carcinomatosis. It is clear that malignant cells can be obtained from the pulmonary ...

To the Editor: A randomized Canadian study¹ found little difference in the risk to the fetus between chorionic villus sampling in the first trimester and amniocentesis for the prenatal diagnosis of genetic disease in women over 35 years of age. Since ...

To the Editor: We wish to describe a situation in which use of the polymerase chain reaction (PCR) can lead to genotyping errors. We have previously reported conditions for the analysis of a restriction-fragment–length polymorphism (RFLP) at the D7S8 ...

To the Editor: The article by Eisenberg (June 8 issue)¹ and the accompanying editorial by Federman² argue convincingly that it is in society's best interest to help finance ambulatory care education. They conclude that such an investment by the public ...

To the Editor: Perhaps the most dramatic change in health care has occurred because a fundamental change in the organization of health care delivery into health maintenance organizations (HMOs) and related structures has been coupled with the perceived ...

To the Editor: In his Sounding Board article (June 22 issue),* Dr. Bricker points out some of the dilemmas surrounding the American Surgical Association's resolution on the ethics of physicians' accepting gifts from profit-making medical companies in ...

To the Editor: We would like to describe a partial solution to the problems posed by Solomon (June 22 issue)* that has worked well in our practice. Since 1976 we have had a clinical pharmacist associated with our clinic. We also have a committee charged ...

Challenges to the tax-exempt status of not-for-profit hospitals have been a recurring issue for most of this decade. The favorable tax treatment accorded not-for-profit hospitals has been reexamined at all levels for which taxing authority exists.¹ Large ...

Nineteenth-century women shared with each other the experiences of pregnancy, childbirth, child nurture, and child death. American historians have appreciated these universal ties among women and have begun to draw conclusions about the larger meaning of ...

This is a welcome addition to the literature on contraceptive practices. The editors have put together a compendium of important information. The book's clinical emphasis should be helpful to the practitioner. Sufficient attention is also given to the ...

This compact book represents a new phenomenon in its field. It is not intended as a short textbook of reproductive endocrinology and would not serve as such, even though the material in many chapters constitutes a brief review of the subject. The topics ...

Neurologic disorders are among the most common medical complications of pregnancy. The obstetrician—gynecologist must not only be able to care for patients with common problems, such as headache, backache, or carpal tunnel syndrome, but should also be ...

The management of medical complications in pregnancy represents a challenging area for both obstetricians and internists. This second edition of Medical Disorders in Obstetric Practice provides an in-depth review of obstetrical medicine and effectively ...

COMPUTER BULLETIN BOARD

The service is provided for residents and medical students and has a toll-free access number: (800) 876–4867 (natl.) or (301) 574–6460 (local).

Contact Dr. Joseph Kaplan, Franklin Square Hosp. Ctr., 9000 Franklin Square Dr., ...

An Outbreak of Shigellosis Associated with the Consumption of Raw Oysters (July 27, 1989; 321:224–7). On page 226, in the right-hand column, six lines from the bottom, "plasma profile" should have read "plasmid profile." We regret the error.

Oral Hypoglycemic Agents (November 2, 1989; 321:1231–45). On page 1234, the legend accompanying Figure 2 should have stated that the figure was used with the permission of the publisher of the journal Diabetes, in which it had originally appeared in an ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...