IN most forms of chronic renal insufficiency, progression to end-stage renal failure is inevitable once a certain percentage of nephrons is lost. The studies of Brenner et al.¹ have resurrected the work of Addis,² who suggested more than 40 years ago that ...

ESTIMATES of the dietary requirement of vitamin D in elderly people differ widely. Although the recommended dietary allowance is 200 IU per day,¹ levels of 400^{2 , 3} to 800 IU^{4 , 5} have been suggested for older people. This wide range of recommended ...

MYCOSIS FUNGOIDES is a generally indolent cutaneous T-cell lymphoma characterized by a neoplastic proliferation of mature helper T cells.^{1 2 3 4} Clinically distinct presentations of mycosis fungoides include limited or widespread cutaneous plaques, ...

HUMAN immunodeficiency virus type 1 (HIV-1) infection and disease have been recognized in pediatric patients since 1983.^{1 2 3} The initial reports described children with nonspecific conditions, such as failure to thrive, oral candidiasis, lymphadenopathy, ...

THE physiologic importance of growth hormone in adults is not known,¹ and there is little information on its effects after linear growth is completed.^{2 , 3} In children with growth hormone deficiency, treatment with human growth hormone has a major effect ...

BIRTH centers are nonhospital facilities organized to provide family-centered maternity care for women judged to be at low risk of obstetrical complications. The first birth centers were developed to serve rural communities. In 1975, the Maternity Center ...

Presentation of Case

A 62-year-old man was referred to the hospital because of bone pain and hypophosphatemia.

He was well until 10 years earlier, when a diagnosis of primary hypothyroidism was made and levothyroxine was begun. Five years before admission ...

Mycosis fungoides is one of a family of uncommon cutaneous T-cell lymphomas that includes the Sézary syndrome, tumeur d'emblée, Ki-1–positive lymphoma, and the adult T-cell leukemia or lymphoma caused by the type C retrovirus human T-cell lymphotropic ...

Delivery outside the high-technology atmosphere of the hospital is an attractive alternative to many women. Although an exact estimate of the number of women who deliver in birth centers is unavailable, in 1980 between 1 and 4 percent of American women ...

To the Editor: Both the U.S. Physicians' Health Study (July 20 issue)¹ and the British Doctors' Study² found no significant differences in mortality from all causes or from cardiovascular disease between aspirin-treated and placebo or untreated groups. ...

No extract is available for articles shorter than 400 words.

To the Editor: Successful treatment of children with acute lymphocytic leukemia raises the issue of potential long-term toxic effects, such as those addressed in the July 20 issue.^{1 2 3} Members of the Children's Cancer Study Group have been assessing the ...

To the Editor: The article by Andress et al. (Aug. 3 issue)¹ shows that refractory osteitis fibrosa in patients on long-term hemodialysis can be treated effectively with intravenous calcitriol. We are, however, a little concerned about the actual long-...

To the Editor: The occupational risk among health care workers of infection with the human immunodeficiency virus (HIV) remains an important issue.^{1 2 3} This risk has been traditionally evaluated in terms of seroconversion among health care workers after ...

No extract is available for articles shorter than 400 words.

The teaching of histology is in a period of transition engendered by several factors. One is the rapid development of new knowledge, crowding the time constraints imposed by revision of curricula. In addition, the expertise of faculty is dwindling as ...

No extract is available for articles shorter than 400 words.

If Polonius were recommending this book to modern medical students and added his celebrated advice, "Neither a borrower nor a lender be," he would soon see that this advice was not only nugatory but also a waste of time. Six editions in less than 20 years,...

The 1937 edition of this book was the first textbook to emphasize a regional approach to gross anatomy. The author used schematic diagrams generously and employed lucid prose to illuminate basic principles of design that are often difficult for students ...

The senior author conceived the idea for this book while she was taking a gross anatomy course. She wanted to create a book written from the student's perspective, a book she and other students were looking for but had been unable to find. Do students ...

This is an attractive book. The core material of pharmacology is presented in 60 chapters divided into nine sections. A 10th section is devoted to special topics. Two appendixes — one on important drug interactions and the other on complex biologic ...

Biomedical Science

Advances in Gene Technology: Molecular neurobiology and neuropharmacology. (ICSU Short Reports. Vol. 9.) Edited by Richard L. Rotundo and 10 others. 162 pp., illustrated. Washington, D.C., IRL Press, 1989. $50.

Carbohydrates and Energy ...

CLINICAL ECONOMICS

The conference will be held in Philadelphia on Jan. 17.

Contact Dr. Mary Kaye Willian, Philadelphia Assoc. for Clinical Trials, 150 Radnor-Chester Rd. D200, St. Davids, PA 19087; or call (215) 687–5454.

NEURAL NETWORKS

The international ...