IDIOPATHIC dilated cardiomyopathy is a primary disease of cardiac muscle that results in systolic and diastolic dysfunction and ventricular enlargement. Its manifestations are heart failure, ventricular and atrial arrhythmias, conduction disturbances, ...

CHANGES in the osmolarity and ion composition of the bronchial periciliary fluid may be important factors in the bronchial response to physical stimuli.^{1 2 3} We have previously shown that inhaled furosemide, a loop diuretic that can interfere with ion and ...

THE incidence of diabetic end-stage renal disease is higher among blacks than among whites,^{1 2 3 4 5 6 7} by about 3.2-fold on average. It is unclear whether this difference reflects the higher prevalence of diabetes among blacks as compared with whites,⁸ ...

THE proliferation of B lymphocytes infected with Epstein–Barr virus (EBV) can result in serious or fatal disease in immunocompromised recipients of kidney, heart, liver, thymus, or allogeneic bone marrow transplants.^{1 2 3 4 5 6} Lymph nodes or other ...

MUCH of the recent improvement in clinical outcomes for patients with kidney transplants may be attributed to the introduction in late 1983 of the immunosuppressive medication cyclosporine. Even with these improved outcomes, the annual cost of the ...

(Second of Two Parts)

Rejection and Histocompatibility

Although the possibility of rejection is always present, nonimmunologic causes of early hepatic dysfunction must be ruled out systematically. The differential diagnosis can include suboptimal ...

LIVER transplantation reverses a number of inborn errors of metabolism that result from the genetically determined absence of an enzyme.¹ The earliest enzyme-deficiency disorders to be treated by liver transplantation were those that caused the anatomical ...

Presentation of Case

A 64-year-old woman was admitted to the hospital because of Clostridium perfringens sepsis, a gallbladder mass, dysproteinemia, and progressive neuropathy.

She was well until three months earlier, when she entered another hospital ...

The diagnosis of dilated cardiomyopathy is made when left ventricular dilatation and systolic dysfunction, with normal wall thickness, occur in the absence of coronary artery, valvular, or pericardial disease.¹ The right ventricle is also often involved. ...

During the past decade, the increased acceptance of diabetic and older patients to receive renal replacement therapy has caused diabetes mellitus to be recognized as one of the leading causes of end-stage renal disease in the United States. Diabetes now ...

No extract is available for articles shorter than 400 words.

To the Editor: Most orphan drugs would not exist today if Congress had not encouraged the Food and Drug Administration and the pharmaceutical industry to foster their development through the Orphan Drug Act, an important and socially useful law. ...

To the Editor: The article by Sandler et al. (May 11 issue)¹ describes a multicenter case–control epidemiologic study examining the possible relation between commonly used analgesics and the subsequent development of chronic renal disease. The findings ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The recent observation that nerve fibers immunoreactive to vasoactive intestinal polypeptide (VIP) are absent in the airways of patients with asthma is of great interest,¹ and appears to support the idea that the absence of this ...

No extract is available for articles shorter than 400 words.

To the Editor: Rationing has been proposed as one possible solution to the current crisis of cost in health care. But it is a response laden with a tangle of ethical and political problems, not the least of which is the danger of arbitrarily dropping ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This manual opens with the rhetorical question, "Why would anyone want to add yet another basic text on clinical hematology to the plethora already available?" The authors answer this by addressing discrete sets of clinical problems and then demonstrating ...

No extract is available for articles shorter than 400 words.

This awesome book contains contributions from 132 experts and is as good a reference as one can find in this field. The rapid growth of our knowledge of rheumatic disease was brought home to me when I counted 19,724 references in 116 chapters. One fifth ...

Inflammatory bowel disease still awaits clarification of its many mysteries. Decades of research have failed to elucidate the causes and pathogenesis of its various component disorders. The relation between the gastrointestinal and the extraintestinal ...

No extract is available for articles shorter than 400 words.

Radiology

Brain Imaging: An introduction. By John R. Bradshaw. 249 pp., illustrated. Boston, Wright, 1989. $70.

Computed Tomography of the Whole Body. Second edition. Edited by John R. Haaga and Ralph J. Alfidi. 1428 pp. in two volumes, illustrated. St. ...

DRUG REGULATION AND AVAILABILITY

The conference, subtitled "Balancing the Needs of the Individual and Those of Society," will be held in Tysons Corner/Vienna, Va., Oct. 26 and 27. A limited number of scholarships are available; call (312) 645–5581.

...

El Salvador has a long history of human-rights abuses and a documented record of violations of medical neutrality and international humanitarian law. Four medical human-rights delegations have visited El Salvador since the outbreak of a civil war between ...