LARON dwarfism is a genetic disease^{1 , 2} caused by target resistance to the action of growth hormone (GH).^{3 , 4} This rare autosomal recessive syndrome is clinically indistinguishable from isolated GH deficiency and is biologically characterized by very ...

MULTIPLE endocrine neoplasia type 2a is a dominantly inherited genetic condition affecting 1 in 25,000 persons,¹ in whom medullary thyroid carcinoma and pheochromocytoma develop.² Because the early recognition and removal of medullary thyroid carcinomas ...

LAURENCE–MOON–BIEDL syndrome has traditionally been described as characterized by retinal dystrophy, polydactyly, obesity, mental retardation, spastic paraparesis, and hypogonadism.^{1 , 2} We have recently reported that the syndrome includes the presence of ...

THE rate of change in the size of abdominal aortic aneurysms and the risk of rupture are issues of increasing clinical interest. With greater use of abdominal ultrasonography and computed tomographic scanning, even in the absence of specific screening ...

(First of Two Parts)

ADVANCES in the management of both chronic and acute hepatic disease have been made possible and even mandated by the development of liver transplantation. The clinical use of transplantation has proceeded at a rapid pace since a ...

CHOLINERGIC neurons affect tissues by releasing the neurotransmitter acetylcholine, which stimulates acetylcholine receptors on the cell surface. These receptors are classified as nicotinic or muscarinic receptors on the basis of their response to the ...

Presentation of Case

A 65-year-old man was admitted to the hospital because of bullous cellulitis of the left lower extremity.

The patient was in a stable state of health until seven days earlier, when he waded in the muddy waters, with oil slicks, of an ...

TWO elegant studies reported in this issue of the Journal ^{1 , 2} demonstrate the value of collaboration between clinicians and molecular biologists in applying the newer techniques of DNA analysis that increasingly permit us to understand disease at the ...

Infrarenal abdominal aortic aneurysm is generally considered to be a serious disorder. Early studies of patients with abdominal aortic aneurysm by Estes¹ and by Wright and associates² indicated that death occurred unpredictably in about half the patients ...

PUBLIC attention was focused on the use of anabolic–androgenic steroids by the disqualification of Ben Johnson, winner of the gold medal for the 100-meter dash in the 1988 Olympic Games. Johnson recently acknowledged that he took anabolic–androgenic ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The recent paper by Marks et al. (April 20 issue)¹ and the editorial in the same issue by Devereux² purport to identify the patients with mitral-valve prolapse who are at high risk for complications. We contend that both the diagnosis of ...

To the Editor: Approximately one in six couples in the United States is experiencing infertility. The aging of the baby-boom generation, delayed childbearing, and a decreased availability of infants for adoption all contribute to the increasing requests ...

Although mountain climbing has been popular for more than a century, only in the past few decades has it been pushed to extremes: at least 20 persons have reached the highest point on earth while breathing only air, and thousands venture where their ...

It is now almost 30 years since humans first entered low earth orbit. This adventure was undertaken by a Soviet cosmonaut, Yuri Gagarin, on April 12, 1961, and by an American, Alan Shepard, on May 5, 1961. Since then almost 300 people have been in low ...

Here is a book with the coherence of subject matter and uniformity of style that one would naturally associate with an autobiographical work. However, as Baird Hastings himself says about it, "It's not an autobiography. It's my story of the development of ...

Thomas McKeown's The Role of Medicine (Princeton, N.J.: Princeton University Press, 1980) is one of the truly original and important books in medicine. On the basis of the intellectual credentials demonstrated in that work, he is a writer of considerable ...

Designed as a textbook for medical students, this is a reference book that will be equally useful to health workers, factory managers, and union representatives. General in approach, it covers the range of occupational illnesses and injuries as well as ...

This new dictionary contains some 100,000 entries, a series of color illustrations and line drawings, and two tables. Some practical characteristics make it easy to use: the print is large enough to be easily readable, subentries as well as main entries ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

ON October 11, 1989, the Institute of Medicine of the National Academy of Sciences released a report on a two-year study of the effects of medical professional liability on the delivery of obstetrical care.¹ The report, which is summarized below, and its ...