TWO assumptions have hindered the evaluation of systemic therapy in women with primary breast cancer and negative axillary nodes. It has been thought that such patients have a good prognosis and that only surgery is needed for their treatment. Findings ...

IN September 1985, the National Institutes of Health Consensus Development Panel on Adjuvant Chemotherapy and Endocrine Therapy concluded that there was sufficient information to make recommendations regarding the treatment of patients with primary breast ...

THE need for postoperative adjuvant systemic therapy in the treatment of primary breast cancer with pathologic involvement of the axillary lymph nodes has been well established. The continued observation of high recurrence and death rates among patients ...

ADJUVANT chemotherapy, endocrine therapy, and combined treatment with chemotherapy and endocrine therapy have been shown to prolong disease-free survival and overall survival in patients with operable breast cancer.^{1 2 3 4} Evidence of this effect was ...

FAMILIAL male precocious puberty is a form of isosexual precocious puberty, occurring in boys, that is independent of luteinizing hormone–releasing hormone (LHRH).^{1 2 3 4 5} The pattern of inheritance is autosomal dominant, although sporadic cases can ...

RECENTLY, we reported the detection of Epstein–Barr virus (EBV) DNA in tissues from approximately 20 percent of patients with Hodgkin's disease.¹ An analysis of the terminal portions of the EBV genome indicated a monoclonal or oligoclonal proliferation of ...

THE National Center on Child Abuse and Neglect estimates that between 2000 and 5000 children are fatally abused annually in the United States.¹ Since Caffey's classic report in 1946,² radiologists have become increasingly aware of a wide variety of ...

THE acardius fetal malformation, occurring once in every 35,000 births, was first described by Benedetti in an account published in 1533.¹ This rare, lethal malformation of one of twin fetuses has four main types: acardius acephalus, in which there is an ...

Presentation of Case

First admission. A 46-year-old woman was admitted to the hospital because of cognitive impairment and cerebrospinal fluid pleocytosis.

She was well until four months earlier, when her relatives began to notice progressive loss of ...

No extract is available for articles shorter than 400 words.

Axillary-node–negative breast cancer develops in approximately 70,000 women in the United States each year. Local surgery, radiotherapy, or both lead to long-term survival in the great majority (approximately 70 percent) of such women. Most do not have ...

This issue of the Journal contains four articles important to the 70,000 women in the United States in whom node-negative breast cancer develops each year.^{1 2 3 4} They provide these women with an option—an option, however, that they can reasonably ...

Although Hodgkin's disease was the first of the malignant lymphomas to be described as a specific disease process, this unique cancer has been the source of many persistent questions over the past 150 years. One enigma has been the paucity of the Reed–...

Much of our ability to recognize child abuse depends on the findings of diagnostic radiology. Although the physical abuse of children has been recognized in various forms for many centuries,¹ modernday awareness of the problem can be traced to Caffey's ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Bloom — Philip Bloom, M.D., of Melrose, died on November 24. He was 87.

Dr. Bloom received his degree from St. Louis College of Physicians and Surgeons in 1927. He was a member of the American Medical Association.

Carey — Edmund L. Carey, M.D., of Milton, ...

Our first book here, edited by Donegan and Spratt, is in its third edition. Like the preceding editions, this one is a state-of-the-art classic on breast cancer. The editors and publisher have again distinguished themselves by gathering past and current ...

This atlas is the culmination of many years of work in the field by one of the most experienced mammographers in this country. The first chapter discusses the controversy over radiation. The author makes the point that with current mammographic equipment, ...

No extract is available for articles shorter than 400 words.

This multiauthored book attempts "to present detailed information on concepts, methods, and techniques of treating maxillofacial trauma." Each chapter discusses maxillofacial injuries thoroughly, including complex comminuted fractures. The chapters ...

Over the past decade, the scope and complexity of ophthalmic surgery have greatly increased. The advent of microsurgery in the 1970s revolutionized eye surgery, heralding the development of specialized intraocular techniques that were formerly impossible. ...

No extract is available for articles shorter than 400 words.

EPILEPSY

The 4th Pan American Congress will take place in Cartagena, Colombia, May 2–5.

Contact Dr. Carlos Medina-Malo, Calle 77, No. 15–80 Of. 406, Bogota. Colombia.

CANADA/UNITED STATES HEALTHCARE

A conference, entitled "Leadership in an Era of Hard ...