INTERLEUKIN-1 and tumor necrosis factor are polypeptide cytokines synthesized by monocytes and other cells in response to injury, as well as to infectious, inflammatory, or immunologic challenges.^{1 2 3} These cytokines induce local inflammatory changes and ...

IT is generally accepted that there are both allergic and nonallergic forms of asthma, and the distinction is usually based on the presence or absence of allergy skin-test reactivity to one or more aeroallergens considered capable of inducing the disease. ...

IT is now well established that parathyroid hormone is a key regulator of the renal production of 1,25-dihydroxyvitamin D3 (1,25(OH)₂D).^{1 2 3} Parathyroid hormone stimulates the renal 1-α-hydroxylase enzyme, leading to increased conversion of 25-...

THE search for effective drugs to combat the acquired immunodeficiency syndrome (AIDS) has focused renewed attention on the process by which the U.S. Food and Drug Administration(FDA) regulates the development and availability of new therapeutic agents. ...

CYTOMEGALOVIRUS (CMV) infections are a major cause of morbidity and mortality among immunocompromised patients, especially recipients of bone marrow and solid-organ transplants and those with the acquired immunodeficiency syndrome (AIDS).^{1 2 3 4} More than ...

RECURRENT herpes simplex virus (HSV) infections are frequent in patients with the acquired immunodeficiency syndrome (AIDS). Although they are usually self-limiting in the normal host, such infections may produce extensive and persistent ulcerative ...

THE most widely used drug therapy for herpes simplex virus (HSV) is the nucleoside analogue acyclovir.^{1 2 3} To inhibit the growth of HSV, acyclovir must first be phosphorylated to the monophosphate form by virus–specific thymidine kinase, followed by ...

Presentation of Case

A 27-year-old woman was admitted to the hospital because of portal-vein thrombosis and an epigastric mass.

The patient was well until 10 days earlier, when moderately severe epigastric pain developed; she was able to continue her work,...

Within the scope of its responsibility for commercial drug development, the Food and Drug Administration also regulates the opportunity for scientific discovery through clinical research. The agency controls the entry of all chemical compounds into ...

Until recently, the problem of resistance to antiviral drugs has been more potential than real. Although individual reports of resistant viruses have appeared, such isolates have been rare and usually of low virulence. The articles by Erlich et al.¹ and ...

The National Leadership Commission on Health Care, which I have discussed before,¹ has just released its final report.² The report is an effort by a blue ribbon panel of private citizens and health professionals representing most of the important ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Cannon-Albright et al. (Sept. 1 issue)¹ suggested that "an inherited susceptibility to colonic adenomatous polyps and colorectal cancer is common and that it is responsible for the majority of colonic neoplasms observed clinically." This ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Steroid-induced mania in patients with renal transplants poses difficult problems.¹ A reduction in the corticosteroid dosage may result in the rejection of the renal transplant. Use of the conventional antimanic agent, lithium, which has a ...

No extract is available for articles shorter than 400 words.

To the Editor: As part of a program to assess the quality of testing done outside the hospital or reference clinical laboratory, we recently studied the performance of home pregnancy-test kits in the hands of laypersons.

Two hundred urine samples from ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In the United States, almost one in four deliveries is by cesarean section. There has been a dramatic rise in the cesarean delivery rate, from less than 5 percent before 1965 to 24.1 percent in 1986. The primary cesarean section rate appears to be ...

While this book is successful, if suffers from its attempt to be innovative in its approach to prepregnancy counseling. It could be a valuable reference book, but if storage space or redundancy is a problem, large portions of the book are already ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

These two books were written as working reference manuals for pathologists. The emphasis is on the light microscopical appearance of lesions.

Biopsy Pathology and Cytology of the Cervix covers the interpretation of cervical cytologic smears as well as ...

The title means what it says. This book truly provides an encompassing presentation of the multifaceted perspectives needed to understand sexual function and dysfunction in those with chronic illness. In this fine work, the authors reveal their extensive ...

When first published in 1976, The Curse, by Delaney, Lupton, and Toth, a feminist approach to the history of menstruation, must have created quite a sensation. These authors, after all, were mentioning the once unmentionable. But as they themselves have ...

Biomedical Science

Advances in Cancer Research. Vol. 51. Edited by George Klein and Sidney Weinhouse. 437 pp., illustrated. San Diego, Academic Press, 1988. $85.

Advances in Immunology. Vol. 43. Edited by Frank J. Dixon, with K. Frank Austen, Leroy E. ...

BIRTH CENTER

Workshops on "How to Establish a Freestanding Birth Center" will be held in Harlingen, Tex., Feb. 23–25; Southfield, Mich., June 22–24; and Philadelphia. Nov. 9–11. Also, the 5th annual meeting of the National Association of Child-bearing ...

No extract is available for articles shorter than 400 words.

Medicare's new health insurance benefit for catastrophic illness, proposed by the Reagan administration and expanded by a Congress hungry to demonstrate its election-year fealty to the elderly, nevertheless incorporates an important policy that is ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...