MITOCHONDRIA are unique among intracellular organelles because they contain their own DNA, which can be transcribed and translated to form proteins. Human mitochondrial DNA is a small (16.5-kilobase [kb]), circular, double-stranded molecule that contains ...

LEBER's hereditary optic neuropathy^{1 2 3} is associated with a rapid bilateral loss of central vision caused by neuroretinal degeneration. During the acute phase of the disease, the retinal vessels are dilated and tortuous, with telangiectasias in the ...

CYCLIC neutropenia (or cyclic hematopoiesis) is a rare blood disease characterized by regular 21-day cyclic fluctuations in the numbers of blood neutrophils, monocytes, eosinophils, lymphocytes, platelets, and reticulocytes.^{1 2 3 4} Patients with the ...

THE measurement of arterial blood gases is critically important in caring for patients with advanced cardiopulmonary disease and a variety of metabolic disorders.¹ The test allows the evaluation of pulmonary gas exchange and is assumed to provide an index ...

NOCTURNAL attacks of wheezy dyspnea, known as "cardiac asthma," are common in patients with impaired left ventricular function. Obstruction of airways is a consistent finding in patients with pulmonary edema and improves at least partially with the ...

OSTEOARTHRITIS, "an almost inevitable consequence of aging,"¹ is second only to cardiovascular diseases in producing severe chronic disability, and it affects nearly 10 percent of the population over the age of 60.² This prevalence and its costs — ...

LEBER'S hereditary optic neuropathy is a disorder of unclear cause. Even among members of the same family, the disorder displays a striking degree of clinical heterogeneity, involving an optic neuropathy, at times a movement disorder, and rarely a ...

Presentation of Case

A 33-year-old woman was admitted to the hospital because of interstitial lung disease.

She was well until five years earlier, when she was admitted to another hospital because of dyspnea and a nonproductive cough. An x-ray film of the ...

Mitochondria are unique among cellular organelles in that they contain their own genetic material—about 2 to 10 copies of a double-stranded, circular DNA molecule that is approximately 16.5 kilobases (kb) in length. This is very small as compared, for ...

Marrow stem cells are driven by a number of regulators, termed colony-stimulating factors or interleukins. Traditionally, the marrow stem cell has been defined by its capacity to renew itself and to differentiate into several types of blood cells. Perhaps ...

Fat, carbohydrate, and much of the protein that we eat are metabolized to form carbon dioxide and water. Each day the body produces approximately 15,000 mmol of carbon dioxide — about 330 liters, or 1.5 lb. Blood courses through capillaries, soaks up this ...

Soon after Laennec's description in 1819 of the invention of the stethoscope and its use in auscultation, the term "cardiac asthma" began to appear in cardiologic treatises. In 1835, Hope¹ wrote that "an immense proportion of asthmas — and of the most ...

To the Editor: Bickel (Dec. 15 issue)¹ mentions that women receive higher marks than men for "humanistic attributes," according to directors of residency training programs. It would be interesting to compare the humanistic qualities of female and male ...

To the Editor: In their article on health care workers exposed to blood from patients infected with the human immunodeficiency virus (HIV), Marcus et al. (Oct. 27 issue)¹ recommend routine HIV antibody testing of all workers soon after exposure, with ...

No extract is available for articles shorter than 400 words.

To the Editor: Lieber states (Dec. 22 issue)¹ that studies conducted in the past two decades in human volunteers and subhuman primates have shown that both the initial liver lesion (fatty liver²) and the ultimate stage of cirrhosis³ can be produced by ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This book is a massive compilation of the papers presented at the Fifth World Congress on In Vitro Fertilization and Embryo Transfer, held in Norfolk, Virginia, in April 1987. More than 1300 scientists from around the world attended the congress, and the ...

No extract is available for articles shorter than 400 words.

There are two phases in the diagnosis of a malformed fetus or stillborn infant: determining that a developmental abnormality is present, and then assessing its importance with respect to cause, category, and the need for counseling. Both phases have ...

Over the past six decades, remarkable improvements in perinatal outcome have been accomplished in pregnancies complicated by insulin-dependent diabetes mellitus. As recently as 1970, 20 percent of such pregnancies resulted in fetal or neonatal death. The ...

The subtitle of this book — The Social Dynamics of Professionalism, 1880–1980 — gives the reader a more accurate clue (or warning, perhaps) about what to expect than the title itself. Although in a sense this is a history of American pediatrics, it is not ...

Pediatric Medicine is an encyclopedic textbook that will be considered a major contribution to education in general pediatrics. The editors have used several stylistic techniques to structure the book that enhance its quality and make it "user friendly." ...

Biomedical Science

Algae as Experimental Systems. (Plant Biology. Vol. 7.) Edited by Annette W. Coleman, Lynda J. Goff, and Janet R. Stein-Taylor. 333 pp., illustrated. New York, Alan R. Liss, 1989. $70.

Cell Biology: An inquiry into the nature of the ...

ALBERT EINSTEIN COLLEGE OF MEDICINE

The following symposia will be held in New York: "2nd Annual Paul Henkind Symposium" (June 2) and "New York Anesthesiology Review: 26th Annual Basic Science Symposium" (June 19–23).

Contact the College, Montefiore ...