CANCER is believed to result from a series of genetic alterations leading to the progressive disordering of the normal mechanisms controlling growth.¹ Colorectal neoplasia provides an excellent opportunity to study this progression because most carcinomas ...

WE demonstrated an inherited susceptibility to adenomatous polyps and colorectal cancers in a large kindred selected because it included three close relatives with colorectal cancer.¹ Members of the family and their spouses were screened by flexible ...

SICKLE cell anemia and β-thalassemia are inherited hématologie disorders that are widespread in regions of the world where malaria was once endemic.¹ Both these autosomal recessive diseases are caused by mutations in the β-globin gene, a gene encoding a ...

THE mechanisms underlying the development of diabetic polyneuropathy remain unknown.^{1 2 3} Chronic hyperglycemia may be a primary event, but rigorous prospective studies await completion.⁴ Chronic hyperglycemia is associated with various metabolic ...

THE distal symmetric polyneuropathy that accompanies diabetes mellitus is by far the most common form of peripheral neuropathy in the Western world^{1 , 2} and is a major contributor to the overall morbidity associated with diabetes.³ Although this condition ...

THE syndrome of humoral hypercalcemia of cancer was first described by Fuller Albright in 1941.¹ When a patient's hypercalcemia and hypophosphatemia resolved after the radiation of a single bone metastasis from a renal carcinoma, Albright proposed that ...

Presentation of Case

A 63-year-old man was admitted to the hospital because of fever and diarrhea.

He was well until nine years earlier, when leukocytosis and splenomegaly were found. Biopsy specimens of the bone marrow and liver were obtained, and a ...

IT is now widely accepted that most tumors are clonal, arising from a single altered cell. There is also evidence that tumor progression, the tendency of a neoplasm to become more aggressive in its clinical and biologic characteristics over time, ...

A tremendous amount of new knowledge about peripheral-nerve function and dysfunction has accumulated over the past 25 years. Advances have come from major technological developments in electrodiagnosis, the morphologic study of nerve, and the application ...

To the Editor: As many as 1 million athletes in the United States may be administering androgenic anabolic steroids to themselves to enhance their performance and alter their physical appearance.^{1 , 2} Regimens include the combination of oral and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The number of helper-inducer (CD4) lymphocytes is an important characteristic of the classification,¹ prognosis,^{2 3 4} and response to treatment⁵ of persons infected with the human immunodeficiency virus (HIV). Heterogeneity of the epitopes ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In their article on the use of the urinary anion gap in assessing hyperchloremic metabolic acidosis, Batlle et al. (March 10 issue)¹ invite criticism on several counts. They claim that the more positive urinary anion gap (sodium plus ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

One may ask, What are surgical infectious diseases? The two-part answer found in this excellent, multiauthored textbook is that they are "infections that appear to be the consequence of an operative procedure, or infections for which surgical therapy may ...

No extract is available for articles shorter than 400 words.

This book, derived from the authors' extensive clinical experience at the Massachusetts General Hospital, deals with such subjects as occlusive cerebrovascular disease, intracranial aneurysms, brain hemorrhage, and arteriovenous malformations of the ...

No extract is available for articles shorter than 400 words.

Their names ring in our ears — Ruysch, Swammerdam, Nuck, Tulp, Barbette, Sandifort, Camper, Bidloo. They were Dutch anatomists, pathologists, surgeons, or all of these. In more recent times, the major contributors to modern surgery — Zaayer, of thoracic-...

Pediatrics

Child Sexual Abuse: A handbook for health care and legal professionals. By Diane H. Schetky and Arthur H. Green. 248 pp. New York, Brunner/Mazel, 1988. $27.50.

Disorders of the Developing Nervous System: Diagnosis and treatment. Edited by ...

NEW YORK UNIVERSITY MEDICAL CENTER

The following courses will be offered in New York: "Basic Sciences Course in Ophthalmology" (Sept. 7–Dec. 23) and "Five-Day Emergency Medicine Board Review Course" (Oct. 10–14).

Contact NYU Post-Graduate Medical School. ...

These guidelines are in accordance with the "Uniform Requirements for Manuscripts Submitted to Biomedical Journals." (The complete document is available in the June 12, 1982, issue of the British Medical Journal and the June 1982 issue of the Annals of ...