RECURRENT infarction and death are common outcomes after myocardial infarction. Several therapeutic approaches have been devised to reduce the frequency of these major complications. Numerous clinical trials have demonstrated the efficacy of beta-blockers ...

LIVER failure after severe acute or subacute hepatitis is an accepted indication for orthotopic liver transplantation. A recent analysis of 29 patients with acute liver failure demonstrated that the odds in favor of survival were greatly increased by ...

GRAM-NEGATIVE septicemia with purpura fulminans has a high mortality rate despite aggressive antibiotic treatment and progress in supportive care. This syndrome is most frequently due to Neisseria meningitidis. Clinical and biologic risk factors have been ...

THE term "juvenile laryngeal papillomatosis" describes a disorder characterized by the growth and relentless recurrence of benign squamous papillomas within the larynx and trachea of both children and adults. Since the disorder can occur in adults and may ...

THE first survey of American adolescents' attitudes toward nuclear weapons and nuclear war was conducted in 1947.¹ Despite World War II's having ended only two years earlier, almost half the 10,000 high-school students polled across the country believed ...

(Second of Two Parts)

Neurohormonal Hypotheses

The cardinal biologic manifestations of major affective disorder consist of alterations in the hypothalamic centers that govern food intake, libido, circadian rhythms, and the synthesis and release of ...

MOST investigators think that estrogen acts indirectly on bone,¹ since direct skeletal action would require the presence of hormone-specific receptors in bone cells.^{2 , 3} However, recent advances in technology have resulted in a renewed effort to identify ...

Presentation of Case

A 71-year-old woman was admitted to the hospital because of cranial-nerve palsies and a grand mal seizure.

She was well from the neurologic standpoint until three months earlier, when progressive dysphagia, dyspnea, and low-back pain ...

IN a study that is a model of scientific collaboration between the United States and the Soviet Union, Eric Chivian and his Soviet and American colleagues in this issue of the Journal ¹ provide a methodologically sophisticated comparison of the attitudes ...

The clinical training of medical students, interns, and residents raises a number of ethical questions. A dilemma faced by all clinical educators is whether to permit a trainee to learn therapeutic and diagnostic procedures by practicing on patients.¹ The ...

To the Editor: In her Sounding Board article (Feb. 18 issue),¹ Dr. June Osborn suggests that quarantine of people infected with human immunodeficiency virus (HIV) "must lurk in the minds of those who seem irresistibly drawn to mandatory screening ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Atrial natriuretic factor (ANF) may have a physiologic role in cardiocirculatory homeostasis. In humans, synthetic α-ANF decreases blood pressure, produces an extravascular shift of fluid, and promotes diuresis and natriuresis.¹ Endogenous ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In his "Choruses from 'The Rock'," T.S. Eliot asks, "Where is the wisdom we have lost in knowledge?/Where is the knowledge we have lost in information?" The lament embodied in these questions resounds in health care. In the future we shall be able to ...

Here are two additions to the growing list of works that address the complex and critical topic of decision making in the area of life-sustaining therapy. These works include articles in mainstream medical journals as well as textbooks, monographs, and ...

No extract is available for articles shorter than 400 words.

Daniel Callahan, director of the Hastings Center and a respected philosopher, has contributed in the past to the ethical analysis of mutual obligation by providing commentary on the limits of autonomy and the folly of pursuing individualism to absurd and ...

There is a growing perception that the young and the old are locked in a fierce competition for limited public resources. Many think that the elderly receive a disproportionate share of available resources, to the detriment of children and the poor. Since ...

Here, the author has provided medical educators with useful background reading to prepare students for case discussion of the ethical conflicts that define clinical practice. Among the many virtues of this slim book is its author's recognition that such ...

Biomedical Science

Advances in Neuroblastoma Research 2. (Progress in Clinical and Biological Research. Vol. 271.) Edited by Audrey E. Evans, Giulio J. D'Angio, Alfred G. Knudson, and Robert C. Seeger. 748 pp., illustrated. New York, Alan R. Liss, 1988. $...

RHEUMATOLOGY FELLOWSHIP

Applications are now being accepted for the Ogryzlo International Fellowship for training in rheumatology at a Canadian rheumatic disease unit for fiscal year 1989. Deadline for receipt of applications is Oct. 15, 1988.

Contact ...