HEPATIC necrosis after acetaminophen overdose results from the increased formation of a highly reactive intermediate (probably N-acetyl-p-benzoquinonimine), produced by acetaminophen metabolism through the cytochrome P-450 mixed-function oxidase system.^{1 ,...}

THE administration of androgens to adolescent boys with constitutional delay of growth and development (constitutional short stature) to initiate the adolescent growth spurt remains highly controversial. Sobel et al.¹ have emphasized the potential of ...

APPROXIMATELY 10 percent of adults in North America have cholesterol gallstones.¹ The prevalence of gallstones is doubled or tripled among patients whose body weight is more than 120 percent of their ideal weight,^{2 3 4 5} and epidemiologic studies have ...

HUMAN immunodeficiency virus (HIV) infection is a progressive, lethal disease that is often accompanied by neurologic disorders, including cognitive changes, progressive dementia, peripheral neuropathy, and paraplegia.¹ Patients who have neurologic ...

IN 1981 Braslow and Heins labeled the 1970s "a decade of remarkable growth for women in academic medicine."¹ They chronicled the increase in the number of women enrolling in medical school and found little difference in the academic performance of male ...

IT is hard to imagine a busy urban hospital without its chorus of "beepers," or radiofrequency paging systems. Yet beepers are a relatively new addition to the hospital ward. As recently as 10 years ago, many hospitals relied for quick communication on "...

NEURAL-CREST cells participate in the embryonic development of the aortopulmonary and conotruncal septa and the thymus and parathyroid glands.¹ The recognition of a clinical syndrome with developmental anomalies of these tissues—the DiGeorge, or "third ...

Presentation of Case

A 72-year-old man was admitted to the hospital because of marked peripheral edema and dyspnea.

He was well until 28 years earlier, when peripheral edema developed. He was admitted to this hospital, where a diagnosis of the nephrotic ...

FOR the great majority of people, acetaminophen is safe if it is used appropriately. It is a good antipyretic agent that effectively relieves mild and moderate pain and has a minor antiinflammatory action. The drug has become highly popular and is ...

THE purposes of the academic health center are to educate tomorrow's health professionals, conduct clinical and basic research, and provide patients with care at a level of technological sophistication usually unavailable in community-based institutions. ...

No extract is available for articles shorter than 400 words.

To the Editor: Zidovudine (3′-azido-3′-deoxythymidine, or AZT) is the only effective drug used in the treatment of AIDS. The mean half-life of the drug is one hour. Long-term administration of 250 mg every four hours in phase II studies¹ resulted in a ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Abnormalities in the display of distinctive differentiation markers (CD4 or CD8) on T-cell subsets have been shown to correlate with the progression of human immunodeficiency virus (HlV)–related disease. In California, the measurement of T-...

To the Editor: The need for early antihypertensive intervention in non-insulin-dependent diabetes (NIDDM) is becoming more and more accepted.¹ In contrast to all other hypotensive agents, angiotensin-converting enzyme inhibitors exert a marginal ...

To the Editor: In 1978 in the Journal, we reported that the frequency of HLA-B35 antigen was increased among 43 patients with idiopathic mesangial IgA glomerulonephritis, as compared with 105 local controls.¹ We are now following 282 patients with this ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: In 1987 Dhondt et al. reported a possibly new variant of impaired biopterin synthesis.* The disorder was detected in an infant 26 days of age through a neonatal screening program because of an elevated blood phenylalanine level and a ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

Interest in the esophagus and in esophageal diseases has escalated over the past 20 years, as evidenced by the proliferation of publications on this subject. Recent books on the esophagus include several multiauthored textbooks on esophageal diseases, ...

Since Codman's landmark textbook on the shoulder was first published in 1934 (The Shoulder, Rupture of the Supraspinatus Tendon and Other Lesions in or about the Subacromial Bursa. Melbourne, Fla.: Krieger, 1984 reprint), several single-authored and ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

CHANGING TIMES IN OB-GYN

The course, subtitled "Ob-Gyn Update: 1989," will be offered in Incline Village, Nev., Jan. 29-Feb. 3.

Contact CME Office, Univ. of California Davis, School of Med., 2701 Stockton Blvd., Sacramento, CA 95817; or call (916) 453–...

No extract is available for articles shorter than 400 words.