ACUTE graft-versus-host disease (GVHD) is a major cause of morbidity and mortality during the first few months after allogeneic marrow transplantation.^{1 2 3 4} In one study of more than 2000 patients who received marrow grafts from HLA-identical sibling ...

COBALAMIN (vitamin B12) deficiency produces a syndrome characterized by abnormalities of the hematopoietic and nervous systems. Although the vitamin appears to be essential for all dividing cells,¹ limited information is available on its effects outside ...

VENOARTERIAL extracorporeal membrane oxygenation (ECMO) is used to treat infants with severe respiratory failure, which is often associated with pulmonary hypertension or circulatory failure and is refractory to management by the use of ventilators and ...

VENTRICULAR dilatation is an important expression of systolic dysfunction of diverse causes, and the extent of dilatation provides important prognostic information. In patients with coronary artery disease, left ventricular volume is the most powerful ...

THERE have been many advances in pediatric surgery since the field was last reviewed in the Journal.^{1 2 3} Pediatric surgery has become a recognized specialty, with 22 training programs approved by the Residency Review Committee of the American Medical ...

THE toxic effects of ethylene glycol result from its metabolic conversion by alcohol dehydrogenase into glycolic acid — a process that causes metabolic acidosis. Glycolate is then metabolized to oxalate, the apparent cause of the renal toxicity of ...

Presentation of Case

A 17-year-old girl was admitted to the hospital because of dyspnea and chest pain.

The patient was well until one year earlier, when she began to experience increasing fatigue, exertional dyspnea and chest pain, and palpitations. She ...

Ethylene glycol is an infrequent but important cause of toxin-induced acute renal failure. Early detection is crucial so that appropriate therapy can be begun to ameliorate the profound metabolic acidosis of early toxicity and prevent the late ...

Graft-versus-host disease (GVHD) holds a dual place in contemporary medicine. Clinically, it presents a serious problem in histocompatible bone marrow transplantation, and it is the principal limitation to histoincompatible bone marrow transplantation. ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: As a Western Collaborative Group Study co-principal investigator,¹ I shall identify omissions in the article by Ragland and Brand (Jan. 14 issue).² Their identification clearly demonstrates that in the Western Collaborative Group Study, ...

No extract is available for articles shorter than 400 words.

To the Editor: Rates of delivery by cesarean section in the United States have increased dramatically during the past two decades. Currently, over 20 percent of the more than 3.5 million babies born each year in this country are delivered by cesarean ...

To the Editor: In humans, the proportion of males at birth, or sex proportion, varies between 0.510 and 0.517 and is remarkably constant among different countries and over time. The overall sex proportion of twins and higher-order multiple births is ...

To the Editor: The economic climate in health care is becoming progressively more charged with urgency about the needs of elderly persons. Particular concern is being expressed about those in whom physical longevity, often achieved at great expense, is ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

A meaningful overview of current practice and future trends in American hospital psychiatry is needed. No one person could achieve this through experience, but this book provides a sensible and thought-provoking perspective.

The book systematically ...

In this book, one of the foremost researchers on alcoholism and the phenomenon of craving presents a thoroughly readable and rich introduction to the subject of the process of recovery from alcoholism. His style of writing is deceptively simple. The text ...

Alcoholism is one of the major medical and psychiatric problems of our day. It is a disorder that engenders intense emotion concerning its nature (disease versus lifestyle), treatment (pharmacologic versus psychological versus spiritual), and strategies ...

Many would agree that Rosenhan's study of psychiatric diagnostic practice exposed the inadequacy of the prevalent diagnostic schema of American psychiatry. In that study, he and his colleagues managed to be diagnosed as having schizophrenia and to be ...

I have felt privileged as a physician to hear patients' tales and, along with other physician-authors, to recognize that there is much to be learned by "interpreting the illness experience." Kleinman is a psychiatrist who "has published widely on the ...

No extract is available for articles shorter than 400 words.

The author of this book has done extensive research in understanding the creative process by means of interviews with literary figures, scientists, and artists. These are people generally acknowledged to be creative. Rothenberg then attempts to show that ...

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ASSOCIATION OF MENTAL HEALTH ADMINISTRATORS

The Annual Meeting will be held in ...

No extract is available for articles shorter than 400 words.