THE correlation between the dose of chemotherapy and tumor cytotoxicity provides the basis for using the maximal tolerated dose of effective agents in the treatment of cancer.¹ A major impediment to dose escalation is infection during the associated ...

INSULIN-DEPENDENT diabetes mellitus (IDDM) affects approximately 1 in 300 people under the age of 20 years in the United States.¹ Current management cannot prevent the long-term complications that reduce life expectancy by one third.² Maintenance of ...

BETTER characterization of the associated clinical syndromes and improved methods of diagnosis¹ have led to more frequent recognition of pancreatic endocrine tumors over the past decade. The most important factor aiding diagnosis has been the development ...

ENCEPHALITIS due to Japanese encephalitis virus is the most common form of epidemic viral encephalitis in the world. It occurs in annual epidemics in Asia, affecting residents, military personnel, and travelers to this region,^{1 2 3 4 5 6} and it is often ...

LAURENCE–MOON–BIEDL syndrome is characterized by obesity, mental retardation, polydactyly, hypogonadism, spastic paraparesis, and pigmented retinal dystrophy.^{1 , 2} In the absence of spastic paraparesis, it may also be designated as the Bardet-Biedl ...

THERE has been considerable public and scientific concern about the possible adverse effects of pertussis vaccine given in combination with diphtheria and tetanus toxoids.^{1 2 3 4 5} One of the most serious of such postulated effects is an increase in cases ...

TRADITIONALLY, the term "prerenal failure" was used to describe a clinical situation in which the structurally intact kidney fails as a result of an impairment in glomerular perfusion. The decreased delivery of blood to the glomerulus was thought to ...

Presentation of Case

A 29-year-old woman was admitted to the hospital because of left flank pain and gross hematuria.

There was a 14-year history of insulin-dependent diabetes mellitus, with poor compliance and 15 previous admissions to a hospital, the ...

Japanese encephalitis has attracted attention recently in the United States, Europe, and Australia because of a small number of cases among travelers, but the epidemic proportions of the disease in Asia have compelled immunization of entire regional or ...

Increasing pressure to contain health care costs has led many hospitals to transfer poor and uninsured emergency department patients to other institutions. The transfer of patients for primarily economic reasons — a practice known as "patient dumping" — ...

To the Editor: Mills and his colleagues in the Diabetes in Early Pregnancy Study (March 17 issue)¹ contend that their data support no relation between increased malformation rates among infants of diabetic mothers and glycemic control during ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: Greenberg et al. (March 10 issue)¹ suggest that nonmedical factors influence the treatment received by persons given a diagnosis of non-small-cell lung cancer. The authors acknowledge that their findings are derived from a predominantly ...

No extract is available for articles shorter than 400 words.

To the Editor: Concerns about the risks of handling tissues from patients with Creutzfeldt–Jakob disease have again been brought to the attention of the medical community by the reports (March 31 issue) of Miller¹ and Sitwell et al.² describing ...

To the Editor: Activation of the expression of the atrial natriuretic factor (ANF) gene has been observed in the ventricles of patients with congestive heart failure^{1 , 2} and, since ANF has natriuretic, diuretic, and vasodilating properties, may be ...

To the Editor: Just as humans prefer to use one hand over the other, they also prefer to use one eye for sighting tasks. This is called ocular sighting dominance. Each eye is bilaterally represented in the brain primarily as a sensory organ, whereas the ...

The publication of the first edition of the Color Atlas of Anatomy in 1983 established a new standard for a moderately priced atlas appropriate for introductory courses. The authors recognized the need for an atlas that transcended the level of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

In our impulse to understand the workings of living cells at increasingly detailed levels, it is easy to overlook the fundamental importance of the relation between structure and function. Structure confers a reality on the conceptualizations of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

DERMATOLOGY RESIDENTS ESSAY CONTEST

Original studies relevant to clinical and basic sciences of dermatology are being accepted for the Jefferson Center for International Dermatology Essay Contest. Deadline for submission is Oct. 1. The winner will present ...