INTERLEUKIN-2, a secretory product of activated T lymphocytes, enhances the in vitro tumoricidal activity of peripheral-blood mononuclear cells¹ and induces the formation of cells, called lymphokine-activated killer cells (LAK cells), capable of lysing ...

HYPOGAMMAGLOBULINEMIA comprises a heterogeneous group of immunodeficiency disorders.^{1 , 2} Of the congenital forms, X-linked agammaglobulinemia has been studied the most thoroughly and is characterized by an absence of B lymphocytes in the bone marrow, ...

OSTEOSARCOMA is a rapidly metastasizing bone tumor that poses difficult challenges to the therapist. Early development of pulmonary metastases in most patients who have undergone amputation but not adjuvant chemotherapy indicates that clinically ...

ADVANCES in noninvasive and invasive cardiac imaging, along with the development of color-flow Doppler echocardiography, have provided the physician with an impressive armamentarium for the diagnosis of valvular heart disease.¹ The proliferation of these ...

MEDICARE'S system of prospective hospital payment based on diagnosis-related groups (DRGs) has been criticized because of the high degree of heterogeneity within patient groups.^{1 , 2} This heterogeneity can lead to at least two problems. First, hospitals ...

Therapeutic Issues

Regionalization of Therapy

The possibility of increasing thrombolysis without causing bleeding has motivated efforts to direct therapy selectively to the pathologic thrombus. Two approaches that have been tried are administration of ...

CHRONIC renal failure connotes the permanent deterioration of the glomerular filtration rate. A urinary creatinine clearance of 5 to 8 ml per minute generally indicates a glomerular filtration rate of less than 5 percent of normal and is usually ...

Presentation of Case

A 32-year-old woman was admitted to the hospital because of recurrent right pneumothorax.

She was well until 32 months earlier, when a spontaneous right pneumothorax developed; a chest tube was inserted, and she recovered in 10 days. ...

IN this issue of the Journal, Lembo et al. provide a convincing report on the efficacy of auscultation in the bedside diagnosis of systolic murmurs.¹ A high degree of accuracy was achieved in a group of 50 patients with a variety of cardiac abnormalities. ...

Recently, controversy has surrounded the field of critical care medicine, as major medical specialties have competed for the rights to this new discipline. Critical care medicine attracted attention in the early 1980s, when more stringent regulations of ...

No extract is available for articles shorter than 400 words.

To the Editor: The editorial explaining and defending the Food and Drug Administration advisory committee's recommendation about t-PA (Dec. 24 issue)¹ did not mention any of the derogatory statements made in the press, especially the financial press, ...

To the Editor: The role of EDTA in the treatment of atherosclerotic disease is extremely controversial. Although the agent has been promoted for more than three decades as a means of promoting regression of atherosclerosis, there are no prospective, ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The Health Consequences of Involuntary Smoking,¹ the 18th Surgeon General's report on smoking, documented the health hazards of involuntary smoking for nonsmokers. This report, combined with lawsuits by nonsmokers² and legislation ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

As the end of the 20th century nears, gynecology has evolved, although somewhat reluctantly, into a socially responsible scientific discipline. Women are now the primary health care consumers and decision makers in the family. This may be due to ...

No extract is available for articles shorter than 400 words.

In the preface to this third edition, the editors state that this textbook "strives to establish the standard of infertility practice in the 1980s." This is indeed a noble objective, but perhaps one that is beyond the scope of any single book today. This ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

This massive two-volume "third edition" is in fact a completely new work. The attribution to Haines and Taylor represents the editor's wish to pay tribute to "the two men who did much to establish the scientific respectability and intellectual credibility ...

This book is an extremely well written and concise review of hemostatic disorders occurring in pregnancy and the newborn period. Because it is the work of only two authors, there is consistency of writing style and presentation. The subject matter is well ...

Biomedical Science

Advances in Immunology. Vol. 41. Edited by Frank J. Dixon. 476 pp., illustrated. Orlando, Fla., Academic Press, 1987. $55.

Biology of the Reptilia. Vol. 16. Ecology B: Defense and life history. Edited by Carl Gans and Raymond B. Huey. ...

SCRIPPS CLINIC

The following conferences will take place in San Diego, Calif.: "Primary Care Medicine: A Practical Approach" (Aug. 26–28); "Lumbar Spine Disease: A Practical Approach for the Primary Care Practitioner" (Sept. 24); and "Infertility Update V"...

Ever since biomedical scientists began using animals as subjects for investigation, they have encountered opposition to the practice.¹ As research on animals and opposition to it have evolved, many of the terms and tactics of confrontation have changed. ...