THE outlook for patients with hairy-cell leukemia has improved considerably in the four years since interferon alfa was shown to have important antileukemic effects in this disease.¹ In most series, more than 90 percent of patients with hairy-cell ...

NEUTROPENIA is a major factor contributing to infection, morbidity, mortality, and underdose in patients undergoing chemotherapy for cancer.¹ An agent capable of either accelerating recovery from or preventing chemotherapy-induced myelosuppression would ...

SYSTEMIC lupus erythematosus is a multisystem disease characterized by B-cell hyperactivity and the formation of pathogenic autoantibodies.^{1 , 2} Patients may also have T-cell lymphopenia and abnormalities of T-cell function, including altered ratios of ...

SYSTEMIC lupus erythematosus, a multisystem disease of unknown cause, has been regarded as the prototype of autoimmune diseases. A reversible lupuslike disorder that occurs in association with the use of certain drugs, most notably procainamide and ...

THE association between malignant mesothelioma and asbestos exposure is well known.^{1 2 3} Often the exposure is not obvious, and careful clinical and epidemiologic investigations are required to identify it. We recently investigated five cases of this ...

THE etiologic agent of the acquired immunodeficiency syndrome (AIDS), human immunodeficiency virus (HIV), induces the progressive, time-dependent destruction of the T4 lymphocyte, a cell that is central to the integrity of the cellular immune system. ...

Presentation of Case

A 13-year-old girl was admitted to the hospital because of amenorrhea and hirsutism.

Her previous medical history was unremarkable. At the age of 10 years the menarche occurred, with generally regular cycles; each menstrual period was ...

The therapeutic potential of interferon has been reviewed twice before in these columns.^{1 , 2} After an initial period of limited availability of the natural material, followed by a period of unrealistic expectations when cloning made interferon readily ...

Systemic lupus erythematosus is one of the connective-tissue diseases whose specific cause or causes remain undetermined. However, it is known that drugs and other agents can produce a lupuslike syndrome: drug-related lupus. The first case of probable ...

IN April the U.S. Congress held two sets of hearings to investigate the extent of fraud in biomedical research and the response of the scientific community to it. Clearly, some members of Congress believe that there is a good deal of fraud and, more ...

To the Editor: Rothenberg et al. report (Nov. 19 issue)¹ that the survival rates for patients with the acquired immunodeficiency syndrome (AIDS) in New York City are substantially higher than those reported in our studies of patients in San Francisco.^{2 ,} ...

To the Editor: Several aspects of the study by Driks et al. (Nov. 26 issue)¹ raise serious questions about the conclusions reached.

First, the incidence of pneumonia with H2-receptor antagonists alone (5.6 percent) was actually lower than that with ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

To the Editor: The myelodysplastic syndromes are a group of hematopoietic stem-cell disorders characterized by cytopenia due to defective erythroid, myeloid, and megakaryocytic maturation.¹ Transformation to acute nonlymphocytic leukemia occurs in 30 ...

To the Editor: Simian virus 40 (SV40), a DNA papovavirus, causes a widespread latent infection in Asian monkeys. It was an unrecognized contaminant of viral vaccines prepared from pools of simian kidney cultures and administered to millions of persons ...

No extract is available for articles shorter than 400 words.

To the Editor: Dr. Gates and his colleagues have contributed valuable data in support of the limited effectiveness of adenoidectomy and of tympanostomy-tube placement in certain children with persistent middle-ear effusion.¹ The findings bear directly on ...

To the Editor: The randomized clinical trial of propylthiouracil for treatment of alcoholic liver disease reported in the Journal (Dec. 3 issue)¹ was well designed and well implemented. The authors concluded that propylthiouracil affects long-term ...

No extract is available for articles shorter than 400 words.

AT no time since its introduction nearly 40 years ago has the state of Great Britain's National Health Service (NHS) been a matter of such public concern. Throughout the life of the last Parliament, there was increasing concern about the level of funding ...

In this ambitious undertaking the several authors contribute chapters on the effect of kidney function on nutritional homeostasis and how nutritional factors affect kidney function. This book is particularly useful because it assimilates a large body of ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

The Connecticut Tumor Registry has collected high-quality population-based data on cancer incidence for half a century, and the accumulated information has been used in hundreds of journal articles. However, as the authors of this new compendium point out,...

During the past 40 years, the field of cancer chemotherapy has progressed rapidly — from the use of aminopterin to induce remission in acute leukemia to the recent use of recombinant growth factors during autologous bone marrow transplantation. The ...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

INTERNATIONAL Nd:YAG LASER SYMPOSIUM

The symposium will take place in Los Angeles, Aug. 1–3.

Contact Intl. Laser Fdn., 3960 Park Blvd., Suite E, San Diego, CA 92103; or call (619) 692–9115.

UNIVERSITY OF MICHIGAN

The following courses will be offered: "...

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.

No extract is available for articles shorter than 400 words.